A5100719633- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Head and Neck Surgical Oncology
- interferon and immune responses
- Gene expression and cancer classification
- Kruppel-like factors research
- Lung Cancer Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Infectious Diseases and Mycology
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
Beijing Tongren Hospital
2013-2024
Capital Medical University
2013-2024
Ministry of Education of the People's Republic of China
2020
The University of Texas MD Anderson Cancer Center
2017
Beijing Institute of Education
2015
<sec><b>Objective</b>Patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) are often diagnosed delay and constrained to limited treatment options. The correlation between RAI refractoriness the underlying genetic characteristics has not been extensively studied. </sec><sec><b>Methods</b>Adult patients distant metastatic DTC were enrolled assigned undergo next-generation sequencing of a customized 26-gene panel (ThyroLead). Patients classified into RAIR-DTC or...
BackgroundLaryngeal squamous cell carcinoma (LSCC) is the most common type in head and neck (HNSCC), development progression of LSCC are multistep processes accompanied by changes molecular biology. ObjectiveThe purpose this study was to investigate basis tumorigenesis regional lymph node metastasis LSCC, provide a set genes that may be useful for novel diagnostic markers and/or more effective therapeutic strategies. MethodsA total number 10 patients who underwent surgery primary laryngeal...
It has been demonstrated that PPARG may interact with the PTEN-PI3K/AKT pathway, contributing to its involvement in chemotherapy treatment of hypopharyngeal squamous cell carcinoma (HSCC). However, underlying mechanism remains largely unknown. In this study, gene expression profiles 17 HSCC patients, comprising 8 chemotherapy-sensitive patients (CSP) and 9 chemotherapy-nonsensitive (CNSP), were collected analyzed investigate patterns, correlations, influencing factors PPARG-PTEN-PI3K/AKT...
Background Enhancer of zeste homolog 2 (EZH2) has been shown to contribute tumour development and/or progression. However, the signalling pathway underlying regulation EZH2 in nasopharyngeal carcinoma (NPC) remains unclear. Since contains putative Glycogen synthase kinase 3 beta (GSK3β) phosphorylation motif ADHWDSKNVSCKNC (591) and may act as a possible substrate GSK-3β, it is that inactivation GSK3β lead excessive expression NPC. Method We first examined phosphorylated (p-GSK3β) by...
Acute invasive fungal rhinosinusitis is a lethal infectious process afflicting immunocompromised individuals. Knowledge about this disease still limited due to the scarcity of animal models designed study pathogenesis infection. Mast cells are tissue-resident immune that participate in variety allergic and inflammatory conditions. Limited attention has been given role mast acute rhinosinusitis. Therefore, objectives were create rat model based on analyzing impact different concentrations...
The prevalence of thyroid cancer (TC) is high in the elderly. present study was based on hypothesis that genes, which have increased activity with aging, may play a role development TC. A large-scale literature-based data analysis conducted to explore genes are implicated both TC and aging. Subsequently, mega-analysis 16 RNA expression datasets (1,222 samples: 439 healthy controls, 783 patients TC) test set associated aging but not To uncover possible link between these TC, functional...
Abstract Background and objectives To analyze oncological functional results of transoral minimally invasive surgery (TMIS) for supraglottic laryngeal carcinoma (SGLC), investigate independent prognostic factors. Methods Seventy SGLC patients treated with TMIS were included. The overall survival (OS), recurrence‐free (RFS), postoperative functions analyzed. Results Sixty‐two early‐stage (Tis, T1, T2) eight T3. Eleven received preoperative induction chemotherapy (IC). Sixty laser microsurgery...
Background Sinonasal squamous cell carcinoma (SSCC) and nasal inverted papilloma (NIP) represent the predominant type of malignant benign tumors in sinonasal tract, respectively. CD4+CD25+Foxp3+ natural regulatory T (Treg) cells might play critical role(s) suppression anti-tumor immune response thus shed light on tumor progression from to malignant. Objective This study aimed evaluate frequency suppressive capacity Treg SSCC compared NIP further explore underlying mechanisms. Patients...
To investigate the role of CUG-binding protein 1 (CUGBP1) in human laryngeal cancer, we employed lentivirus-mediated short hairpin RNA (shRNA) to knockdown CUGBP1 expression Hep-2 cells. Depletion remarkably inhibited proliferation induced cell cycle arrest S phase, especially sub-G1 representing apoptotic Knockdown cells markedly increased LIP and cleavage PARP, which could contribute apoptosis. Thus has a critical modulating growth apoptosis, serves as potential therapeutic target cancer.
Thyroid cancer (THCA) is one of the commonest malignancies associated with increased recurrence. Therefore, identifying putative molecular markers and therapeutic targets to improve treatment THCA essential. The present study analyzed potential role tripartite motif‑containing 21 (TRIM21), a member TRIM family belonging subfamily E3 ubiquitin ligases, in progression THCA. Using bioinformatics analysis immunohistochemistry tissues, it was observed that TRIM21 overexpressed tissues. also found...
Our previous study showed that the upregulation of peroxisome proliferator-activated receptor gamma (PPARG) could promote chemosensitivity hypopharyngeal squamous cell carcinoma (HSCC) in chemotherapeutic treatments. Here, we acquired two more independent expression data PPARG to validate levels chemotherapy-sensitive patients (CSP) and its individualized variations compared chemotherapy-non-sensitive (CNSP). results overall was mildly downregulated ( <math...
Zinc finger protein, X-linked (ZFX) is a transcriptional factor involved in many physiological processes such as embryonic stem cell survival and self-renewal. Though ZFX dysfunctions have been identified variant human diseases especially cancers, its pathological roles not fully addressed. Here, we explored the relationship between expression squamous carcinoma (SCC) of tongue. We found that was significantly higher tongue SCC tumors compared to tumor-adjacent normal tissues. Furthermore,...
Previous studies indicate that obesity is an important contributor to the proceeding of thyroid cancer (TC) with limited knowledge underlying mechanism. Here, we hypothesize molecules affected by may play roles in development TC. To test hypothesis above, first conducted a large-scale literature-based data mining identify genes influenced and related Then, mega-analysis was study expression changes obesity-specific case TC, using 16 independent TC array-expression datasets (783 cases 439...