A5026888866- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Carbon and Quantum Dots Applications
- Immune cells in cancer
- Graphene research and applications
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Ion Transport and Channel Regulation
- Characterization and Applications of Magnetic Nanoparticles
- MXene and MAX Phase Materials
- Renal and related cancers
- Neonatal Health and Biochemistry
King's College London
2014-2024
University of North Carolina at Chapel Hill
2021-2024
Binghamton University
2023-2024
California NanoSystems Institute
2019-2022
University of California, Los Angeles
2019-2022
American Pharmacists Association
2022
University of California System
2020
University College London
2016
We developed a custom-designed liposome carrier for codelivery of potent immunogenic cell death (ICD) stimulus plus an inhibitor the indoleamine 2,3-dioxygenase (IDO-1) pathway to establish chemo-immunotherapy approach solid tumors in syngeneic mice. The was constructed by remote import anthraquinone chemotherapeutic agent, mitoxantrone (MTO), into liposomes, which were further endowed with cholesterol-conjugated indoximod (IND) prodrug lipid bilayer. For proof-of-principle testing, we used...
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in allergic and autoimmune disease. The available options for custom-designing tolerogenic NPs include the use of nanocarriers that introduce antigens into natural environments, such as liver, where antigen presentation promotes self- or foreign antigens. Here, we demonstrate engineering a biodegradable polymeric poly(lactic-co-glycolic acid) (PLGA) nanocarrier selective delivery murine allergen, ovalbumin (OVA),...
Abstract There is an urgent need to develop new life‐prolonging therapy for pancreatic ductal adenocarcinoma (PDAC). It demonstrated that improved irinotecan delivery by a lipid bilayer coated mesoporous silica nanoparticle, also known as silicasome, can improve PDAC survival through chemo‐immunotherapy response in orthotopic Kras‐dependent cancer model. This discovery premised on the weak‐basic properties of irinotecan, which neutralizes acidic lysosomal pH cells. effect triggers linked...
Abstract In this study a mesoporous silica nanoparticle (MSNP) based platform is developed for high‐dose loading of range activated platinum (Pt) chemo agents that can be attached to the porous interior through use electrostatic and coordination chemistry under weak‐basic pH conditions. addition design feature improving drug delivery, MSNP also encapsulated in coated lipid bilayer (silicasome), improve colloidal stability after intravenous (IV) injection. Improved pharmacokinetics intratumor...
Abstract Wnt signaling is essential for embryonic development, influencing processes such as axis formation, cell proliferation and differentiation, fate decisions, axon guidance. It also plays a role in maintaining tissue homeostasis adult organisms. The loss of normal polarity adhesion caused by activation fundamental step tumor progression metastasis. Activating the canonical pathway driving force many human cancers, especially colorectal, hepatocellular, mammary carcinomas. causes...
Nanocarriers take advantages of the enhanced permeability and retention (EPR) to accumulate passively in solid tumors. Magnetic targeting has shown further enhance tumor accumulation response a magnetic field gradient. It is widely known that passive nanocarriers varies hugely tissues different vascularization. hypothesized likely be influenced by such factors. In this work, assessed range subcutaneously implanted murine tumors, namely, colon (CT26), breast (4T1), lung (Lewis carcinoma)...
The targeting of natural tolerogenic liver sinusoidal endothelial cells (LSEC) by nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable generating regulatory T-cells (Tregs), which can suppress antigen-specific immune responses, including to ovalbumin (OVA), possible food allergen. In this regard, we have previously demonstrated that OVA-encapsulating poly(lactic-co-glycolic acid) (PLGA) eliminate allergic airway inflammation in OVA-sensitized mice, prophylactically and...
Azide- and alkyne-double functionalised graphene oxide (Click<sup>2</sup> GO) was synthesised characterised with ATR-FTIR, TGA, Raman spectroscopy.
Hyaluronic acid, a natural CD44 receptor ligand, has attracted attention in the past years as macromolecular delivery of anticancer agents to cancer. At same time, clinical applications Gemcitabine (Gem) have been hindered by its short biological half-life, high dose and development drug resistance. This work reports synthesis hyaluronic acid (HA) conjugate for nuclear imaging, vivo Gem CD44-expressing solid tumors mice. HA was individually conjugated, via amide coupling, (HA-Gem),...
Two-dimension graphene oxide (GO) nanosheets with high and low serum protein binding profiles (high/low hard-bound corona/HC
In this study, we propose an organic solvent-free, one-step mechanochemistry approach to engineer water-dispersible graphene oxide/superparamagnetic iron oxide (GO/SPIOs) hybrids, for biomedical applications. Although has been proposed in the field applications such as drug loading, exfoliation or polymer-composite formation, is first study report preparation of GO/SPIOs hybrids. The statistical design experiment (DoE) was employed control process parameters. DoE used formulation processes...
2D boron nitride (BN) and molybdenum disulfide (MoS2 ) materials are increasingly being used for applications due to novel chemical, electronic, optical properties. Although generally considered biocompatible, recent data have shown that BN MoS2 could potentially be hazardous under some biological conditions, example, during, biodistribution of drug carriers or imaging agents the liver. However, effects these on liver cells such as Kupffer (KCs), sinusoidal endothelial cells, hepatocytes,...
Abstract Hard corona (HC) protein, i.e., the environmental proteins of biological medium that are bound to a nanosurface, is known affect fate nanomedicine. Due size, curvature, and specific surface area (SSA) 3‐factor interactions inherited in traditional 3D nanoparticle, HC‐dependent bio–nano often poorly probed interpreted. Here, first HC‐by‐design case study 2D demonstrated sequentially linearly changes HC quantity using functionalized graphene oxide (GO) nanosheets. The quality analyzed...
ABSTRACT Recent research has shown that membrane trafficking plays an important role in canonical Wnt signaling through sequestration of the β-catenin destruction complex inside multivesicular bodies (MVBs) and lysosomes. In this study, we introduce Ouabain, inhibitor Na,K-ATPase pump establishes electric potentials across membranes, as a potent signaling. We find levels are elevated advanced colon carcinoma, enzyme is cancer cells with constitutively activated pathway by GSK3 inhibitors...
Abstract Mesenchymal stem cell (MSC)‐derived extracellular vesicles (EVs) are a promising treatment for myocardial infarction (MI), but their therapeutic efficacy is limited by inefficient accumulation at the target site. A minimally invasive MSC EV therapy that enhances disease site and extends retention could significantly improve post‐infarct cardiac regeneration. Here, we show EVs decorated with next‐generation of high‐affinity (HiA) heterodimerizing leucine zippers, termed HiA...
Magnetic drug targeting has been proposed as means of concentrating therapeutic agents at a target site and the success this approach demonstrated in number studies. However, behavior magnetic carriers blood vessels tumor microcirculation still remains unclear. In work, we utilized polymeric nanocapsules (m-NCs) for tumors dynamically visualized them within tissues before, during after field exposure using fibered confocal fluorescence microscopy (FCFM). Our results suggested that...