A5077774070- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Phagocytosis and Immune Regulation
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Electrospun Nanofibers in Biomedical Applications
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Nanofabrication and Lithography Techniques
- Neuroendocrine Tumor Research Advances
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- CAR-T cell therapy research
- Ion Transport and Channel Regulation
Taipei Medical University
2020-2025
Binghamton University
2024
Purpose: CD3-based Bispecific T-cell engagers (BiTEs) are effective for solid tumors due to their tumor specificity and tissue penetration, but they face challenges like short half-lives narrow therapeutic windows. Innovative delivery systems, thermosensitive hydrogels, show the potential enhance stability, sustained release, efficacy. Methods: We developed PEGylated PLGA (PEG–PLGA) hydrogels with a nonshrinkable property (nsTPPgels) controlled release loaded them bispecific anti-prostate...
Extracellular matrix (ECM) hydrogel can create a favorable regenerative microenvironment and act as promising dressing for accelerating the healing of diabetic wound. In this study, simple effective decellularization technique was developed optimized to obtain acellular extracellular (aECM) from porcine skin. It found that at 30% formic acid 72 h effectively decellularized skin while retaining >75% collagen ~37% GAG in aECM with no presence nuclei cellular remnants. fabricated by digesting...
ABSTRACT Recent research has shown that membrane trafficking plays an important role in canonical Wnt signaling through sequestration of the β-catenin destruction complex inside multivesicular bodies (MVBs) and lysosomes. In this study, we introduce Ouabain, inhibitor Na,K-ATPase pump establishes electric potentials across membranes, as a potent signaling. We find levels are elevated advanced colon carcinoma, enzyme is cancer cells with constitutively activated pathway by GSK3 inhibitors...
In recent years, combining different types of therapy has emerged as an advanced strategy for cancer treatment. these combination therapies, oral delivery anticancer drugs is more convenient and compliant. This study developed irinotecan/rapamycin-loaded lecithin-based self-nanoemulsifying nanoemulsion preconcentrate (LBSNENPir/ra) evaluated its synergistic effects on pancreatic cancer. LBSNENP loaded with irinotecan rapamycin at a ratio 1:1 (LBSNENPir10/ra10) had better drug release profile...