A5070276279- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Methods in Pharmaceuticals
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Collagen: Extraction and Characterization
- Drug Transport and Resistance Mechanisms
- Hydrogels: synthesis, properties, applications
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Mass Spectrometry Techniques and Applications
- Sexual function and dysfunction studies
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Periodontal Regeneration and Treatments
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Fungal Biology and Applications
- Proteins in Food Systems
Taipei Medical University
2015-2024
Zero to Three
2012
Hsing Wu University
2011
National Research Institute of Chinese Medicine
2009-2010
Food Industry Research and Development Institute
2009-2010
Council of Agriculture
2010
National Taitung University
2010
China Medical University
1995-2009
National Taiwan University
2009
Ministry of Justice
2009
In an attempt to accelerate wound healing by stimulating the recruitment of fibroblasts and improve mechanical properties collagen matrixes, N,O-(carboxymethyl)chitosan (NOCC) was incorporated into backbone a (COL) matrix without or with chondroitin sulfate (CS) acellular dermal (ADM). The result cell migration study demonstrated that significantly enhanced NOCC in concentration-dependent manner. analysis dynamic analyzer, NOCC/CS/COL matrixes presented higher tensile strengths than did...
Given the growing number of arthritis patients and limitations current treatments, there is great urgency to explore cartilage substitutes by tissue engineering. In this study, we developed a novel decellularization method for menisci prepare acellular extracellular matrix (ECM) scaffolds with minimal adverse effects on ECM. Among all acid formic treatment removed most cellular contents preserved highest ECM in decellularized porcine menisci. Compared fresh menisci, content DNA decreased...
Platelet-rich plasma (PRP) containing autologous growth factors is applied in regenerative medicine, but the lack of an optimized PRP preparation protocol causes unstable therapeutic effects. The aim this study was to optimize method and compare effects from different methods restoration erectile function a rat model. vivo experiments used Sprague–Dawley male rats (n = 24), which were randomly divided into four groups equal numbers: group I underwent sham operation, while remaining three...
Abstract: To resolve problems of long treatment durations and frequent administration the antifungal agent terbinafine (TB), solid lipid nanoparticles (SLNs) with ability to load lipophilic drugs nanosize were developed. The SLNs manufactured by a microemulsion technique in which glyceryl monostearate (GMS), behenate (Compritol ® 888; Gattefossé), palmitostearate (Precirol ATO 5; Gattefossé) used as phases, Tween Cremophor series surfactants, propylene glycol cosurfactant construct ternary...
Abstract The goal of this study was to assess the incorporation exudates human platelet‐rich fibrin (hPRF) that is abundant in platelet cytokines and growth factors into biodegradable (FB) scaffolds as a regeneration matrix for promoting chondrocyte proliferation re‐differentiation. hPRF obtained from blood by centrifugation without an anticoagulant, exudate collected mixed with bovine fibrinogen, then thrombin added form FB scaffold. Proliferation differentiation primary chondrocytes...
Abstract Self-assembling mixed polymeric micelles ( sa MPMs) were developed for overcoming major obstacles of poor bioavailability (BA) associated with curcumin delivery. Lecithin added was functioned to enlarge the hydrophobic core MPMs providing greater solubilization capacity. Amphiphilic polymers (sodium deoxycholate [NaDOC], TPGS, CREMOPHOR, or a PLURONIC series) examined potentially self-assembling form addition lecithin. Particle size, size distribution, encapsulation efficacy (E.E.),...
Abstract: Quercetin (Que) is known to have biological benefits including an anticancer effect, but low water solubility limits its clinical application. The aim of this study was develop a lecithin-based mixed polymeric micelle (LMPM) delivery system improve the and bioavailability Que. optimal Que-LMPM, composed Que, lecithin, Pluronic ® P123, 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -methoxy[poly(ethylene glycol)-2000] in proportion 3:1:17.5:2.5 (w/w), prepared by thin-film...
In this study, a double emulsion method for complexing plasmids with stearyl poly-ethylenimine (stPEI) as the core to form human serum albumin (HSA) (plasmid/stPEI/HSA) nanoparticles (NPs) was developed gene delivery by non-covalently binding onto plasmid/stPEI/HSA CRISPR/Cas9 or siRNA, which disrupts silences expression of programmed cell death ligand-1 (PD-L1) immunotherapy.Chemically synthesized stearyl-polyethyenimine (stPEI)/plasmids/HSA were maded method. They characterized dynamic...
Aim: A thermosensitive injectable hydrogel composed of nanocomplexes doxorubicin and hyaluronic acid (HA) for the local treatment cancer diseases was developed characterized. Materials & methods: It found that addition a divalent metal ion Mg (MgCl2) required to properly form HA–doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) hydrogels. Results: The DH700KMF-15 resulted in efficient growth inhibition C26 colon cells it selectively targeted lymphatic system by...
Extracellular matrix (ECM) hydrogel can create a favorable regenerative microenvironment and act as promising dressing for accelerating the healing of diabetic wound. In this study, simple effective decellularization technique was developed optimized to obtain acellular extracellular (aECM) from porcine skin. It found that at 30% formic acid 72 h effectively decellularized skin while retaining >75% collagen ~37% GAG in aECM with no presence nuclei cellular remnants. fabricated by digesting...
Objective: This study was intended to utilize lecithin-based mixed polymeric micelles (lbMPMs) for enhancing the solubility and bioavailability of honokiol magnolol resolve hindrance their extreme hydrophobicity on clinical applications.Methods: Lecithin selected increase volume core lbMPMs, thereby providing a greater solubilization capacity.A series amphiphilic polymers (sodium deoxycholate [NaDOC], Cremophor ®, Pluronic ® series) were included with lecithin screening optimization.Results:...