A5081187066- Skin Protection and Aging
- Genomics, phytochemicals, and oxidative stress
- Photodynamic Therapy Research Studies
- Redox biology and oxidative stress
- Advanced Glycation End Products research
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Vitamin C and Antioxidants Research
- Indoor Air Quality and Microbial Exposure
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Click Chemistry and Applications
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- bioluminescence and chemiluminescence research
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
University of Arizona
2016-2025
University of Arizona Cancer Center
2014-2024
University of Montana
2023
Tangshan People's Hospital
2015
Eli Lilly (United States)
2015
Adelphi Group (United Kingdom)
2015
Senju Pharmaceutical (United States)
2015
Institute of Pharmacology
2009-2014
Technische Universität Berlin
1994-2005
Teradyne (United States)
2001
Drug resistance during chemotherapy is the major obstacle to successful treatment of many cancers. Here, we report that inhibition NF-E2-related factor 2 (Nrf2) may be a promising strategy combat chemoresistance. Nrf2 critical transcription regulating cellular protective response defends cells against toxic insults from broad spectrum chemicals. Under normal conditions, low constitutive amount protein maintained by Kelch-like ECH-associated protein1 (Keap1)-mediated ubiquitination and...
OBJECTIVE To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve function during the course of streptozotocin (STZ)-induced diabetic nephropathy. RESEARCH DESIGN AND METHODS Diabetes was induced in Nrf2+/+ Nrf2−/− mice by STZ injection. Sulforaphane (SF) or cinnamic aldehyde (CA) administered weeks after injection metabolic indices structure were assessed (18 weeks). Markers diabetes including blood glucose,...
The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for the development more efficacious strategies targeting wound healing. In current study, using human clinical specimens, we show that perilesional tissues from patients with diabetes are under severe oxidative stress display higher activation nuclear factor-E2-related factor 2 (NRF2)-mediated antioxidant response than normoglycemic patients. a streptozotocin-induced mouse model, Nrf2(-/-) mice have...
Colorectal cancer (CRC) is a major cause of tumor-related morbidity and mortality worldwide. Recent research suggests that pharmacological intervention using dietary factors activate the redox sensitive Nrf2/Keap1-ARE signaling pathway may represent promising strategy for chemoprevention human including CRC. In our search Nrf2 activators with potential chemopreventive activity targeting CRC, we have focused studies on trans-cinnamic aldehyde (cinnamaldeyde, CA), key flavor compound in...
Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photocarcinogenesis and photoaging, an urgent need exists for improved strategies photoprotection. The redox-sensitive transcription Nrf2 (nuclear factor-E2-related 2), master regulator of the cellular antioxidant defense against environmental electrophilic insult, has recently emerged as important determinant cutaneous damage from UV, concept pharmacological activation attracted considerable attention novel approach...
The NF-E2 p45-related factor 2 (Nrf2) signaling pathway regulates the cellular antioxidant response and activation of Nrf2 has recently been shown to limit tissue damage from exposure environmental toxicants, including As(III). In an attempt identify improved molecular agents for systemic protection against insults, we have focused on identification novel medicinal plant-derived activators.Tanshinones [tanshinone I (T-I), tanshinone IIA, dihydrotanshinone, cryptotanshinone],...
Glyoxalase I [lactoylglutathione lyase (EC 4.4.1.5) encoded by GLO1] is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, cytotoxic byproduct glycolysis. Accumulative evidence suggests an important role GLO1 expression protection against methylglyoxal-dependent protein adduction and damage associated with diabetes, cancer, chronological aging. On basis hypothesis that upregulation may play functional glycolytic adaptations cancer cells, we examined status...
Abstract The progressive nature of colorectal cancer and poor prognosis associated with the metastatic phase disease create an urgent need for development more efficacious strategies targeting carcinogenesis. Cumulative evidence suggests that redox-sensitive transcription factor Nrf2 (nuclear factor-E2–related 2), a master regulator cellular antioxidant defence, represents promising molecular target chemoprevention. Recently, we have identified cinnamon, ground bark Cinnamomum aromaticum...
Pharmacological inhibition of autophagic-lysosomal function has recently emerged as a promising strategy for chemotherapeutic intervention targeting cancer cells. Repurposing approved and abandoned non-oncological drugs is an alternative approach to the identification development anticancer therapeutics, antimalarials that target functions have attracted considerable attention candidates oncological repurposing. Since cumulative research suggests dependence on autophagy represents specific...
Abstract Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due lung edema, trauma, or general anesthesia. However, MV causes ventilator-induced injury (VILI), condition characterized by increased permeability of alveolar-capillary barrier results hemorrhage and neutrophil infiltration, leading exacerbated inflammation oxidative stress. This study explored feasibility using bixin, canonical NRF2 inducer...
The discovery of biomarkers for Parkinson's disease (PD) is challenging due to the heterogeneous nature this disorder, and a poor correlation between underlying pathology clinically expressed phenotype. An ideal biomarker would inform on PD-relevant pathological changes via an easily assayed biological characteristic, which reliably tracks clinical symptoms. Human dermal (skin) fibroblasts are accessible peripheral cells that constitute patient-specific system, potentially recapitulates PD...
N-Substituted pyrroles (1), 2-furaldehyde (2), and N-substituted 2-formylpyrroles (3), formed in pentose (hexose) Maillard systems, were identified as components of extraordinary polycondensation activity. The was studied model experiments with N-methylpyrrole (1a)/N-methyl-2-formylpyrrole (3a), N-(2-methoxycarbonylethyl)pyrrole (1b)/N-(2-methoxycarbonylethyl)-2-formylpyrrole (3b), N-methyl-2-formylpyrrole (1a)/2-furaldehyde (1b)/2-furaldehyde respectively. MALDI-TOF-MS spectra indicated...
The differentiated epidermis of human skin serves as an essential barrier against environmental insults from physical, chemical, and biological sources. Zinc pyrithione (ZnPT) is FDA-approved microbicidal agent used worldwide in clinical antiseptic products, over-the-counter topical antimicrobials, cosmetic consumer products including antidandruff shampoos. Here we demonstrate for the first time that cultured primary keratinocytes melanocytes display exquisite vulnerability to nanomolar...