A5100662766- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Mental Health Research Topics
- Mental Health and Psychiatry
- Genetic Associations and Epidemiology
- Obsessive-Compulsive Spectrum Disorders
- Attention Deficit Hyperactivity Disorder
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Personality Disorders and Psychopathology
- Transcranial Magnetic Stimulation Studies
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Hormonal Regulation and Hypertension
- Dementia and Cognitive Impairment Research
- Renin-Angiotensin System Studies
- Diabetes Treatment and Management
- Cognitive Functions and Memory
- Neurological disorders and treatments
- Neuroscience and Music Perception
Suzhou Guangji Hospital
2016-2025
Soochow University
2016-2025
Kunming Institute of Zoology
2020
Chinese Academy of Sciences
2020
Wenzhou Medical University
2014-2020
Institute of Psychology, Chinese Academy of Sciences
2019
Jinzhou Kangning Hospital
2014-2019
Jiangsu Provincial Center for Disease Control and Prevention
2019
Beijing HuiLongGuan Hospital
2012-2014
Peking University
2012-2014
To identify promising drug targets for psychiatric disorders, we applied Mendelian randomization (MR) design to systematically screen blood metabolome potential mediators of disorders and further predict target-mediated side effects.We selected 92 unique metabolites from 3 genome-wide association studies (GWASs) with totally 147 827 participants. Summary statistics bipolar disorder (BIP), attention deficit hyperactivity (ADHD), obsessive-compulsive (OCD), major depressive (MDD),...
Objective: Antipsychotics are widely used for treating psychosis, but it is unclear whether they can also prevent psychosis. This study attempted a longitudinal evaluation of antipsychotics under real-world conditions in China to evaluate their effect on the rate conversion psychosis individuals with clinical high risk (CHR) Method: A total 517 CHR were recruited between 2011 and 2016 followed up 3 years. Among these, 450 (87.0%) completed follow-up, 108 (24.0%) showed 309 (68.7%) received...
Genome-wide association studies (GWAS) of major depression and its relevant biological phenotypes have been extensively conducted in large samples, transcriptome-wide analyses the tissues brain regions to pathogenesis depression, e.g., dorsolateral prefrontal cortex (DLPFC), also widely performed recently. Integrating these multi-omics data will enable unveiling risk genes even underlying pathological mechanisms. Here, we employ summary data-based Mendelian randomization (SMR) integrative...
Abstract Lipid profile (total cholesterol and lipoprotein fractions) has been found to correlate with depression cognitive impairment across the lifespan. However, role of lipid levels in self-rated depressive state remains unclear. In this study, we examined relationship between cholesterol, triglycerides, high-density low-density cholesterol) cognition adults without depression. Four hundred thirty-eight healthy participants completed Repeatable Battery for Assessment Neuropsychological...
Tumor necrosis factor-α (TNF-α) had been identified as a key pro-inflammatory cytokine in the pathophysiology of major depressive disorder (MDD) and mechanism antidepressant treatment. The primary aim present study was to examine serum TNF-α levels Chinese inpatients with MDD during acute phase explore changes after effective clinical Fifty-seven consecutive 30 healthy controls were recruited. detected using ELISA. Symptoms depression evaluated 24-item Hamilton Rating Scale for Depression...
Abstract Background The effect of neuroinflammatory cytokines on cognitive deficits in patients with major depressive disorder (MDD) can be altered by selective serotonin reuptake inhibitors (SSRIs). This study aimed to examine serum interleukin-8 (IL-8) levels, function, and their associations MDD SSRIs. Methods Thirty SSRI-treated 101 healthy controls were recruited for this study. We examined performance using the Repeatable Battery Assessment Neuropsychological Status (RBANS) IL-8 levels...
Abstract Background The pathophysiology of cognitive impairment in patients with the major depressive disorder (MDD) may involve neuroinflammation mediated by cytokines. Objective aim this study was to examine serum interleukin-6 (IL-6) levels, sustained attention, and their association MDD. Methods Thirty MDD 30 healthy controls were enrolled case-control study. Sustained attention measured using Rapid Visual Information Processing (RVP) task Cambridge Neuropsychological Tests Automated...
Abstract Background Only 30% or fewer of individuals at clinical high risk (CHR) convert to full psychosis within 2 years. Efforts are thus underway refine identification strategies increase their predictive power. Our objective was develop and validate the accuracy individualized components a mobile app-based calculator (RC) in CHR sample from SHARP (ShangHai At Risk for Psychosis) program. Method In total, 400 were identified by Chinese version Structured Interview Prodromal Syndromes....
Since only 30% or fewer of individuals at clinical high risk convert to psychosis within 2 years, efforts are underway refine identification strategies increase their predictive power. The is a heterogeneous syndrome presenting with highly variable symptoms and cognitive dysfunctions. This study investigated whether subtypes defined by baseline features improve the prediction psychosis.Four hundred high-risk subjects from ongoing ShangHai At Risk for Psychosis program were enrolled in...
Abstract Background Age effects may be important for improving models the prediction of conversion to psychosis individuals in clinical high risk (CHR) state. This study aimed explore whether adolescent CHR (ages 9–17 years) differ significantly from adult 18–45 terms rates and predictors. Method Consecutive ( N = 517) were assessed demographic characteristics followed up 3 years. Individuals with classified as n 244) or 273) groups. Age-specific generated separately using Cox regression....