A5059533675- Acute Ischemic Stroke Management
- Genetic Associations and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Nutrition and Health in Aging
- Studies on Chitinases and Chitosanases
- GDF15 and Related Biomarkers
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Bone Metabolism and Diseases
- Polyamine Metabolism and Applications
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Bone and Dental Protein Studies
- Cancer, Lipids, and Metabolism
Soochow University
2020-2025
North China University of Science and Technology
2022-2023
First Affiliated Hospital of Soochow University
2023
Tulane University
2022
People's Liberation Army 401 Hospital
2022
University of Chicago
2022
Agostino Gemelli University Polyclinic
2022
Institut Pasteur de Lille
2022
Centre Hospitalier Universitaire de Lille
2022
Cedars-Sinai Medical Center
2022
Abstract Aims Sleep disorders are associated with an increased risk of cardiometabolic diseases in observational studies, but the causality remains unclear. In this study, we leveraged two-sample Mendelian randomization (MR) analyses to assess causal associations self-reported daytime napping, sleepiness, and other sleep phenotypes including ischaemic stroke (IS), coronary artery disease (CAD), heart failure (HF), Type 2 diabetes mellitus (T2DM). Methods results We selected genetic variants...
Abstract Background Breast cancer is the most common among women with limited treatment options. To identify promising drug targets for breast cancer, we conducted a systematical Mendelian randomization (MR) study to screen blood metabolome potential causal mediators of and further predict target-mediated side effects. Methods We selected 112 unique metabolites from 3 large-scale European ancestry-based genome-wide association studies (GWASs) total 147,827 participants. data were obtained...
To identify promising drug targets for psychiatric disorders, we applied Mendelian randomization (MR) design to systematically screen blood metabolome potential mediators of disorders and further predict target-mediated side effects.We selected 92 unique metabolites from 3 genome-wide association studies (GWASs) with totally 147 827 participants. Summary statistics bipolar disorder (BIP), attention deficit hyperactivity (ADHD), obsessive-compulsive (OCD), major depressive (MDD),...
Previous study found that estimated glucose disposal rate (eGDR) was significantly associated with cardiovascular disease (CVD). However, little is known about the change in eGDR over time and its association development of CVD. The aim this to investigate CVD risk.
Background and Purpose: Complement C3 has been implicated in inflammation ischemia/reperfusion injury, but its impact on the prognosis of ischemic stroke remains unclear. Aim this study was to prospectively investigate association between serum complement adverse clinical outcomes after stroke. Methods: We measured levels for 3474 patients with 26 participating hospitals collected data at 3 months The primary outcome composite death major disability (modified Rankin Scale score ≥3) onset...
Poststroke cognitive impairment is a severe and common clinical complication that constitutes substantial global health burden. We aimed to evaluate the association of 3 cardiac biomarkers in combination with poststroke their prognostic significance.
Polyamines have been suggested to play pivotal roles in ischemic stroke and neurodegenerative disorders, but the associations of plasma polyamines with poststroke cognitive impairment (PSCI) remain unclear. We aimed prospectively investigate putrescine, spermidine, spermine PSCI among patients a multicenter cohort study. measured polyamine levels at baseline 619 from preplanned ancillary study CATIS (China Antihypertensive Trial Acute Ischemic Stroke). used Mini-Mental State Examination...
Background Our study aimed at evaluating the association between plasma human cartilage glycoprotein‐39 (YKL‐40) and cognitive impairment 3 months among patients with acute ischemic stroke. Methods Results Plasma YKL‐40 levels were measured in 604 participants from China Antihypertensive Trial Acute Ischemic Stroke. Cognitive outcomes assessed poststroke using Mini‐Mental State Examination Montreal Assessment. According to score, highest quartile of had a 2.01‐fold (95% CI, 1.23–3.29; P for...
Background: Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals different metabolic or genetic status remains unclear. Methods: We included 464 483 participants from UK Biobank who were free major cardiovascular disease HF during baseline recruitment. Healthy avoidance smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 4 factors), intermediate (2 unfavorable (0 1 factor) lifestyles....
BDNF (brain-derived neurotrophic factor) has been implicated in cardiovascular homeostasis and ischemic stroke pathogenesis. We aimed to prospectively investigate the associations between serum levels prognosis of a multicenter cohort study.This prospective study follows STROBE reporting guideline. Serum concentrations were measured 3319 patients from China Antihypertensive Trial Acute Ischemic Stroke August 2009 May 2013 26 hospitals across China. The primary outcome was composite death...
Background We examined whether the relationship between baseline platelet count and clinical outcomes is modulated by HS‐CRP (high‐sensitivity C‐reactive protein) in patients with ischemic stroke. Methods Results A total of 3267 stroke were included analysis. The primary outcome was a combination death major disability at 1 year after Secondary disability, death, vascular events, composite events or an ordered 7‐level categorical score modified Rankin Scale year. Multivariate logistic...
Increased blood pressure (BP) variability is positively associated with the risks of cerebral small-vessel disease, cardiovascular events and death. However, no large clinical trials have been published to demonstrate effect BP fluctuations during hospitalization on outcomes after ischemic stroke.A total 3972 patients acute stroke from 26 participating hospitals were included in this study, calculated using data collected hospitalization. The primary outcome was composite death or major...
BDNF (brain-derived neurotrophic factor) is widely implicated in the pathophysiological process of stroke, but effect on poststroke cognitive impairment (PSCI) remains unclear. We aimed to investigate association between baseline serum and risk PSCI at 3 months a multicenter study based preplanned ancillary CATIS trial (China Antihypertensive Trial Acute Ischemic Stroke).
Objective Rheumatoid arthritis (RA) is suggested to be implicated in the development of cardiometabolic diseases. We conducted a Mendelian randomization (MR) study assess potential causality for associations RA with risk diseases, including type 2 diabetes (T2D), coronary artery disease (CAD), and ischaemic stroke.Method Seventy independent single-nucleotide polymorphisms (SNPs) associated were identified as instrumental variables from genome-wide association (GWAS) 58 284 European subjects....
Abstract Atopic dermatitis is a chronically recurrent dermatologic disease affected by complex pathophysiology with limited therapeutic options. To identify promising biomarkers for atopic dermatitis, we conducted Mendelian randomization (MR) study to systematically screen blood metabolome potential causal mediators of and further predict target-mediated side effects. We selected 128 unique metabolites from three European-descent genome-wide association studies (GWASs) total 147 827...