A5051330892- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Nanoparticles: synthesis and applications
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Air Quality and Health Impacts
- Infectious Encephalopathies and Encephalitis
- Metabolism and Genetic Disorders
- Blood Pressure and Hypertension Studies
- Mosquito-borne diseases and control
- Heavy Metal Exposure and Toxicity
- Vitamin D Research Studies
- Protease and Inhibitor Mechanisms
- Vitamin C and Antioxidants Research
- Studies on Chitinases and Chitosanases
- Nutrition and Health in Aging
- Cardiac Health and Mental Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Microbial Metabolic Engineering and Bioproduction
- GDF15 and Related Biomarkers
- Neurological and metabolic disorders
Soochow University
2016-2025
The Royal Melbourne Hospital
2024
The University of Melbourne
2024
University of Chinese Academy of Sciences
2023
Second Affiliated Hospital of Soochow University
2022
Tulane University
2022
Soochow University
2016
Suzhou Research Institute
2016
In-Q-Tel
2016
Shandong University
2012
Abstract Background The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, two simple surrogate indicators of insulin resistance, have been demonstrated predict cardiovascular disease (CVD). However, very few studies investigated their associations with CVD in European populations. Methods A total 403,335 participants from the UK Biobank data for TyG TG/HDL-C ratio free at baseline were included. Cox models applied evaluate association...
Choline metabolism was suggested to play pathophysiological roles in nervous system and atherosclerosis development. However, little is known about the impacts of choline pathway nutrients metabolites on poststroke cognitive impairment. We aimed prospectively investigate relationships between circulating choline, betaine, trimethylamine N-oxide with impairment among acute ischemic stroke patients.We derived data from CATIS (China Antihypertensive Trial Acute Ischemic Stroke). Plasma...
Background Epidemiological studies have reported discrepant findings on the relationship between education level and outcomes after stroke. We aimed to prospectively investigate mortality, recurrent stroke, cardiovascular events in Chinese patients with ischemic Methods Results included 3861 participants from China Antihypertensive Trial Acute Ischemic Stroke. Education was categorized as illiteracy, primary school, middle college. Study were all-cause stroke-specific within 2 years A...
Clinically significant changes in neurological deficits frequently occur after stroke onset, reflecting further injury or improvement. However, the National Institutes of Health Stroke Scale (NIHSS) score is only evaluated once most studies, usually at onset. Utilizing repeated measures NIHSS scores to identify different trajectories function may be more informative and provide useful predictive information. We determined association with long-term clinical outcomes ischemic stroke.A total...
Background Our study aimed at evaluating the association between plasma human cartilage glycoprotein‐39 (YKL‐40) and cognitive impairment 3 months among patients with acute ischemic stroke. Methods Results Plasma YKL‐40 levels were measured in 604 participants from China Antihypertensive Trial Acute Ischemic Stroke. Cognitive outcomes assessed poststroke using Mini‐Mental State Examination Montreal Assessment. According to score, highest quartile of had a 2.01‐fold (95% CI, 1.23–3.29; P for...
NAD-independent L-lactate dehydrogenase (l-iLDH) and D-lactate (D-iLDH) activities are induced coordinately by either enantiomer of lactate in Pseudomonas strains. Inspection the genomic sequences different strains revealed that lldPDE operon comprises 3 genes, lldP (encoding a permease), lldD an L-iLDH), lldE D-iLDH). Cotranscription lldP, lldD, aeruginosa strain XMG starts with base, C, is located 138 bp upstream ATG start codon. The adjacent to lldR FadR-type regulator, LldR). gel...
Considering the increasing applications of silver nanoparticles (AgNPs) in food- and cosmetic-related products worldwide, aim this study was to investigate potential adverse health effects induced by AgNPs exposure terms cytotoxicity, oxidative stress, mitochondrial injury human A549 HepG2 cells.After a 48 h treatment, cell viability measured MTT assay. Oxidative damage determined assays malondialdehyde (MDA), 8-epi-PGF2α 8-hydroxy-2'-deoxyguanosine (8-oxo-dG). The protein expression HSPA1A...
Abstract With the rapid expanding of human exposure to silver nanoparticles (AgNPs), genotoxicity screening nanosilver is necessary ensure consumer safety. Here, we assessed one key DNA damage responsive pathway activated by GADD45a gene after 24 h AgNPs in stable luciferase reporter cell systems based on two widely used vitro models, liver HepG2 and lung epithelial A549 cells. The comet assay micronucleus test were also conducted confirm genetic induced AgNPs. Our results showed that...
Patients with stroke are often affected by varying degrees of functional disability and have different evolution patterns in disability. However, little is known about the predictive usefulness changes after stroke. We aimed to describe 1-year trajectories assess associations longitudinal 24-month clinical outcomes ischemic
Several studies have indicated that residual cardiovascular risk might be associated with elevated lipoprotein(a) [Lp(a)] even in the setting of controlled low-density lipoprotein cholesterol (LDL-C). We aimed to prospectively examine association between Lp(a) and unfavorable functional outcome among patients acute ischemic stroke when LDL-C were discordant.Based on samples from Infectious Factors, Inflammatory Markers Prognosis Acute Ischemic Stroke study, 973 baseline plasma levels...
The expression of tissue inhibitor metalloproteinase-1 (TIMP-1) significantly increased after acute cerebral ischaemia and involved in neurodegeneration. purpose was to prospectively investigate the relationship between serum TIMP-1 with post-stroke cognitive impairment. Our participants were from an ancillary study China Antihypertensive Trial Acute Ischemic Stroke. 598 ischaemic stroke patients seven participating hospitals included. Cognitive impairment evaluated using Mini-Mental State...
Background:Matrix metalloproteinase-9 (MMP-9), a key determinant of extracellular matrix degradation, might cause cerebral damage after stroke and be involved in the development depressive symptoms. This study aimed to evaluate association serum MMP-9 levels post-stroke depression (PSD).
Abstract Objectives The intense commercial application of silver nanoparticles (AgNPs) has been raising concerns about their potential adverse health effects to human. This study aimed explore the potency AgNPs induce GADD45α gene, an important stress sensor, and its relationships with cytotoxicity genotoxicity elicited by AgNPs. Methods Two established HepG2 A549 cell lines containing promoter‐driven luciferase reporter were treated increasing concentrations for 48 hours. After treatment,...
The use of silver nanoparticles (AgNPs) in consumer products and medical applications is growing rapidly owing to their noted antimicrobial properties. As a consequence, rapid reliable toxicology test that allows multiple nanosilver screening stress responsive pathway-based assay needed ensure safety. Here, novel HSPA1A promoter-driven luciferase reporter gene assays based on two cell models widely used testing, HepG2 A549 lines, were developed analyze the oxidative elicited by AgNPs. After...
Background: L-carnitine has been shown to exert neuroprotective effects on cerebral ischemia, mainly by improving mitochondrial function and reducing inflammation. supplementation also promoted enhance cognitive function. However, the relationship between impairment after ischemic stroke seldom studied. Objective: We aimed evaluate association plasma poststroke impairment. Methods: The study sample population was drawn from China Antihypertensive Trial in Acute Ischemic Stroke. Plasma were...
Abstract Background and objectives Evidence on the associations between baseline stromal cell-derived factor (SDF)-1 clinical outcomes in acute ischemic stroke patients is lacking. The present study aimed to examine relationship plasma SDF-1 levels based a large multicenter of China Antihypertensive Trial Acute Ischemic Stroke (CATIS). Methods Secondary analysis was conducted among 3,255 participants from CATIS trial with measurement levels. We evaluated one-year recurrent stroke,...