A5021530377- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Hepatitis B Virus Studies
- Inflammation biomarkers and pathways
- Hepatitis C virus research
- Noise Effects and Management
- IL-33, ST2, and ILC Pathways
- Acute Ischemic Stroke Management
- Air Quality and Health Impacts
- Tryptophan and brain disorders
- Apelin-related biomedical research
- Dementia and Cognitive Impairment Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Human Health and Disease
- RNA Interference and Gene Delivery
- Stroke Rehabilitation and Recovery
- Asthma and respiratory diseases
- Healthcare Systems and Public Health
- Animal Virus Infections Studies
- Nuclear Receptors and Signaling
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Immune cells in cancer
Soochow University
2017-2024
Changshu No.1 People's Hospital
2024
Soochow University
2021
Nanjing Medical University
2010-2011
Nanjing Brain Hospital
2010-2011
BDNF (brain-derived neurotrophic factor) has been implicated in cardiovascular homeostasis and ischemic stroke pathogenesis. We aimed to prospectively investigate the associations between serum levels prognosis of a multicenter cohort study.This prospective study follows STROBE reporting guideline. Serum concentrations were measured 3319 patients from China Antihypertensive Trial Acute Ischemic Stroke August 2009 May 2013 26 hospitals across China. The primary outcome was composite death...
Occult hepatitis B virus infection (OBI) is an important risk factor of liver cirrhosis and hepatocellular carcinoma. Type 1 interferon (IFN) signaling-related miRNAs were significantly associated with (HBV) infection. However, the characteristics serum IFN in OBI remain unclear. Therefore, this study aimed to analyze expression levels evaluate their potential values for diagnosis. Twenty samples training test (10 healthy controls 10 patients) 438 validation from controls, asymptomatic HBsAg...
Soluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk incident stroke. However, the impact sST2 on function after ischemic stroke is unclear. We aimed assess association impairment at 3 months in acute patients.Baseline plasma levels were measured 619 patients (mean age: 60.0 ± 10.5 years) from 7 participating hospitals China Antihypertensive Trial Acute Ischemic Stroke. Montreal Cognitive Assessment (MoCA) Mini-Mental State...
Abstract Background Occupational class is an integral part of socioeconomic status. The studies focused on the occupational difference in ischemic stroke outcome a Chinese population are limited. We aimed to investigate associations between and prognosis patients with China. Methods included 1484 participants (mean age: 63.42 ± 11.26 years) from prospective cohort study: Infectious Factors, Inflammatory Markers Prognosis Acute Ischemic Stroke (IIPAIS). was categorized into white-collar...
Abstract Background Previous studies suggested that elevated levels of plasma soluble triggering receptor expressed on myeloid cells 2 (sTREM2) was related to increased risk death, cardiovascular events and cognitive impairment after stroke. We aimed prospectively investigate the association between sTREM2 post-stroke depression (PSD). Methods measured in 590 ischemic stroke patients from China Antihypertensive Trial Acute Ischemic Stroke. The 24-item Hamilton Rating Scale for Depression...
Inflammation is a key role in the pathogenesis of Alzheimer disease (AD). Accumulating studies demonstrate that excess tumor necrosis factor- alpha (TNF-α) plays important roles pathogenesis, progress AD. Some clinical evidence shows anti-TNF-α therapy improves cognition rapidly, however mechanism remains to be elucidated. We compared effects ICV TNF-α monoclonal antibody (Infliximab) versus PBS on pathological changes aged APP/PS1 double transgenic mice, respectively 3 days, 7 and 14 days...
Abstract Background: Soluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk incident stroke. However, the impact sST2 on function after ischemic stroke is unclear. We aimed assess association impairment at 3 months in acute patients. Methods: Baseline plasma levels were measured 619 patient (mean age: 60.0 ± 10.5 years) from 7 participating hospitals China Antihypertensive Trial Acute Ischemic Stroke. Montreal Cognitive Assessment...
Abstract Background Occupational class is an integral part of socioeconomic status. The studies focused on the occupational difference in ischemic stroke outcome a Chinese population are limited. We aimed to investigate associations between and prognosis patients with China. Methods included 1484 participants (mean age: 63.42 ± 11.26 years) from prospective cohort study: Infectious Factors, Inflammatory Markers, Prognosis Acute Ischemic Stroke (IIPAIS). was categorized into white-collar...