A5045107955- Cardiac electrophysiology and arrhythmias
- Genetic Associations and Epidemiology
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Bipolar Disorder and Treatment
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Cardiac Imaging and Diagnostics
- Tryptophan and brain disorders
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Circadian rhythm and melatonin
- Psychiatric care and mental health services
- Ion channel regulation and function
- Mental Health Treatment and Access
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Treatment of Major Depression
- Cardiovascular Syncope and Autonomic Disorders
- Cognitive Abilities and Testing
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Phosphodiesterase function and regulation
National Institute of Mental Health
2014-2020
National Center of Neurology and Psychiatry
2014-2020
Fujita Health University
2005-2017
Aoyama Gakuin University
2014-2017
Tottori University Hospital
2014-2017
National Hospital Organization
2014-2017
University of Occupational and Environmental Health Japan
2014-2017
Toho University
2014-2017
Nagoya University
2017
Seiwa Hospital
2014
Aims: Abnormalities in dopaminergic and serotonergic transmission systems are thought to be involved the pathophysiology of schizophrenia mechanisms underlying therapeutic effects antipsychotics. We conducted a pharmacogenetic study evaluate whether variants dopamine-related genes (DRD1–DRD5, AKT1 GSK3β) serotonin receptor (HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6 HTR7) can used predict efficacy risperidone treatment for schizophrenia. Materials & methods: A total 120 first-episode...
Abstract Recent progress in genotyping technology and the development of public databases has enabled large‐scale genome‐wide association tests with diseases. We performed a two‐stage study (GWAS) bipolar disorder (BD) Japanese cohorts. First we used Affymetrix 100K GeneChip arrays analysis 107 cases I controls, selected markers that were nominally significant ( P < 0.01) at least one three models (1,577 total). In follow‐up stage, analyzed these using an Illumina platform (1,526 markers;...
Several lines of evidence suggest that alterations in circadian rhythms might be associated with the pathophysiology psychiatric disorders such as schizophrenia and bipolar disorder (BP). A recent study reported SIRT1 is a molecule plays an important role clock system. Therefore, to evaluate association among gene, BP, we conducted case-control Japanese population samples (1158 patients, 1008 BP patients 2127 controls) four tagging SNPs (rs12778366, rs2273773, rs4746720 rs10997875) gene....
Virtual Electrodes in Defibrillation. Introduction : We recently demonstrated that virtual electrode‐induced phase singularity is responsible for arrhythmogenesis during T wave shocks and explains the upper lower limits of vulnerability. Furthermore, we suggested same mechanism might he defibrillation failure. The aim this study was to experimentally support hypothesis. Methods Results used voltage‐sensitive dye di‐4‐ANEPPS fast imaging assess electrical activity Langendorff‐perfused rabbit...
Aims: The aim of this study was to analyze the relation between treatment response and duration untreated illness (DUI) in 133 outpatients with first major depressive disorder (MDD) episode. Methods: A logistic regression performed DUI, sex, age at onset, score for 17 items on Hamilton Depression Rating Scale time start fluvoxamine as explanatory variables, remission outcome variables. Results: Regression analysis showed significant association DUI ( P < 0.0001), respectively. rate...