A5005156882- Dementia and Cognitive Impairment Research
- Genetic Associations and Epidemiology
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Personality Disorders and Psychopathology
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Genomic variations and chromosomal abnormalities
- Schizophrenia research and treatment
- Genomics and Rare Diseases
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Perfectionism, Procrastination, Anxiety Studies
- Genetic Syndromes and Imprinting
- Health and Wellbeing Research
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Psychosocial Factors Impacting Youth
Pusan National University
2015-2025
Pusan National University Hospital
2016-2025
Biomedical Research Institute
2018
Texas Tech University Health Sciences Center
2017
Texas Tech University
2017
The University of Texas Health Science Center at San Antonio
2007
Pohang University of Science and Technology
2006
Background Hippocampal atrophy is implicated in the early onset of Alzheimer's disease (AD). It closely associated with rapid cognitive decline and serves as a critical predictor for conversion from mild impairment (MCI) to AD. Consequently, growing interest utilizing hippocampal volume (HV) an outcome measure clinical trials, elucidating neurobiological mechanisms underlying essential diagnosing AD predicting its progression. Objective The risk apolipoprotein E ε4 ( APOE4) allele higher...
Colletotrichum panacicola isolates were obtained from anthracnose lesions of Korean ginseng and compared with four species in morphology, molecular phylogeny pathogenicity. Based on morphological characteristics, C. was easily distinguished gloeosporioides but not higginsianum, destructivum coccodes. A phylogenetic tree generated ribosomal DNA-internal transcribed spacer sequences revealed that is remarkably coccodes higginsianum destructivum. However, sequence analysis three combined genes...
Disruption of the circadian rhythm is known as a provoking factor for manic episodes. Individual differences exist in recovery rate from disruption general population. To develop screening method to detect individuals vulnerable bipolar disorder, authors observed relationship between normal sleep-wake cycle after switching light-dark (LD) and quinpirole-induced hyperactivity mice.Sixteen male mice (age 5 weeks, weight 28-29 gm) were subjected protocol. Sleep-wake behaviors checked every min...
The purpose of this study was to determine whether regionally distributed medial temporal cortex thickness (or hippocampal volume) and frontal lobe volume are independently associated with the onset Alzheimer's disease (AD) psychosis.We identified 26 AD patients psychosis (AD+P) 48 without (AD-P) from Memory Impairment Clinic at Pusan National University Hospital in South Korea. They were matched for age, gender, duration AD, Clinical Dementia Rating sum box score. All participants met...
The aim of this study is to investigate whether a combination the Korean version mini-mental state examination (K-MMSE) and dementia screening questionnaire (KDSQ) better than use test alone when differentiating patients with from those without in Korea.The subjects (patients dementia, 1120; 908) were recruited Clinical Research Center for Dementia South Korea. K-MMSE KDSQ used. Diagnosis was made according Diagnostic Statistical Manual Mental Disorders, fourth Edition. weighted sum rule...
The Coping Inventory for Stressful Situations (CISS) is a globally recognized measure of stress coping methods. However, research into the applicability CISS in Korean context still its infancy. aim this study to assess and report validity adults first time.Three hundred two who currently have no distressing problems requiring psychiatric treatment completed version CISS. Principal component analysis was used extract factors process exploratory factor analysis.The result displayed clear...
An association between white matter hyperintensities (WMH) and cognitive dysfunction has long been recognized. However, subjects with identically appearing WMH on magnetic resonance imaging present a wide variance in function ranging from normal cognition to dementia. The aim of this study was compare cortical atrophy integrity patients subcortical vascular dementia Binswanger type (SVaD-BT) those the group (ncWMH).Eleven SVaD-BT 11 age-, sex-, education- grade WMH-matched ncWMH underwent...
As coping strategies can influence the illness course of mood disorder, they could be potential targets for psychological intervention. The current study investigated similarities and differences in stress styles between bipolar disorder (BD) depressive (DD).Subjects with BD (n=135) DD (n=100) who met DSM-IV diagnostic criteria were included this analysis. Coping assessed using inventory stressful situations symptoms by Beck depression inventory.The group showed significantly more avoidant...
Objective Mild cognitive impairment (MCI) usually represents a transitional phase between normal function and dementia, but not all people with MCI develop dementia because is clinically etiologically heterogeneous grouping. The aim of this study was to determine whether clinical subtypes severity white matter hyperintensities (WMH) were associated progression dementia. Method Our cohort consisted 840 patients aged 55 years or older who had diagnosis at their baseline visit least one...
A long-term follow-up study in patients with amnestic mild cognitive impairment (aMCI) is needed to elucidate the association between regional brain volume and psychopathological mechanisms of Alzheimer's disease psychosis (AD + P).The purpose this was investigate effect thickness angular cingulate cortex (ACC) on risk AD P conversion aMCI.This a hospital-based prospective longitudinal including 174 aMCI. The main outcome measure time-to-progression from aMCI P. Subregions ACC (rostral ACC,...
Objective Bipolar and depressive disorders are distinct with clearly different clinical courses, however, distinguishing between them often presents challenges. This study investigates the utility of self-report questionnaires, Mood Disorder Questionnaire (MDQ) Spectrum Diagnostic Scale (BSDS), machine learning-based multivariate analysis, to classify patients bipolar disorders.Methods A total 189 were included in study, all participants completed both MDQ BSDS questionnaires....
Aims: Mild cognitive impairment (MCI) usually represents a transitional phase between normal function and dementia, but not all people with MCI develop dementia because is clinically etiologically heterogeneous grouping. The aim of this study was to compare progression rates Alzheimer's disease (AD) among various subtypes which show minimal white matter ischemia. Methods: Our cohort consisted 504 patients aged 55 years or older who had diagnosis at their baseline visit, least 1 follow-up...
Objective 1) To investigate the relationship between NrCAM polymorphisms and methamphetamine abuse in an ethnically homogenous Korean population. 2) further support our findings by investigating association among gene variants, certain personality traits, addictive symptoms of abusers. Methods Thirty-seven male abusers (age=43.3±7.8) and30 non-users (16 men, 14 women; age=59.8±10.4) were recruited. Ten single nucleotide (SNPs) assayed to compare genotype distributions 2 groups. Personality...
정신질환자의 입원치료는 자아기능의 붕괴로 자신이나 타 인에게 위해를 가할 가능성이 있거나 자기 관리를 할 수 없는 환자에게 적용되는 일종의 적극적 치료방법이다. 입원치료를 통해 환자들은 자신을 재통합할 있도록 안정적이고 지지 적인 환경을 제공받을 있다. 일반적으로 단기입원의 효율 성은 입증되고 있지만, 입원치료기간에 따른 효율성은 아직 까지 논란이 되고 특히 장기입원의 경우에는 입원 서 비스를 얻게 되는 편익보다 정신질환의 관리비용과 의 료급여재정 수요의 증가, 생산적 노동력이 활용되지 못하는 등 손실이 더 커진다고 알려져 또한 환자의 사회생활 능 력이 저하되고 인격이 황폐화되어 사회복귀를 어렵게 하는 소 위 수용소 증후군의 발생가능성이 증가하는 것으로 보고되 고 이에 단기입원과 퇴원 후 지역사회 내에서 환자를 효 과적으로 관리하는 것이 정신질환 치료의 일반적 추세이다. 국내에서는 1995년 정신보건법을 제정하여 정신질환자들 을 단순히 격리수용하는 것에서 벗어나 이들을...
Schizophrenia is the most devastating mental illness that causes severe deterioration in social and occupational functioning. This a pilot study for family-based association analysis of schizophrenia Korean population to search candidate genes functionally relevant positionally on chromosome 18.We have recruited 27 probands (with psychosis) with their parents siblings whenever possible. We analyzed 20 SNPs (Single Nucleotide Polymorphism) seven neuronal 18 DNA samples was checked data...
Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions personality development/degeneration. The present study investigated the heritability and familiality in Korean families with schizophrenic linkage disequilibrium (LD).
Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according of rhythm.The protocol was applied eight-week-old twenty male Institute Cancer Research mice. The patterns were collected through motor measured by Mlog system....