A5060874552- Genetic Associations and Epidemiology
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Genomic variations and chromosomal abnormalities
- Public Health and Social Inequalities
- Forensic and Genetic Research
- Mitochondrial Function and Pathology
- COVID-19 and Mental Health
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Genetic diversity and population structure
- Dementia and Cognitive Impairment Research
- Psychology Research and Bibliometrics
- Psychological Treatments and Disorders
- Cytokine Signaling Pathways and Interactions
- Biological Research and Disease Studies
- Ion channel regulation and function
- Aging, Health, and Disability
Universidad de Costa Rica
2016-2025
The University of Texas Health Science Center at San Antonio
2010
Detroit R&D (United States)
2006
Foundation for the National Institutes of Health
2004
The University of Texas at San Antonio
2001
Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud
1996
<h3>Context</h3> Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given predisposing may be transmitted without expression categorical clinical phenotype, a strategy for identifying risk is identify and map quantitative intermediate phenotypes or endophenotypes. <h3>Objective</h3> To adjudicate neurocognitive endophenotypes disorder. <h3>Design</h3> All participants underwent diagnostic interviews...
Primary--i.e., nonsyndromal-postlingual deafness is inherited as an autosomal dominant phenotype in a large kindred Costa Rica. Genetically susceptible individuals begin to lose hearing at low frequencies about age 10 years, after language and speaking are learned. Deafness inevitably progresses by 30 years bilateral loss of all frequencies. Intelligence, fertility, life expectancy normal. The family traces its ancestry affected founder born Rica 1754. We have mapped the gene for this...
Although genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that predisposing to may be transmitted without expression clinical phenotype, efforts have focused developing endophenotypes. While several neuropsychological measures been proposed endophenotypes, few studies systematically assessed batteries neurocognitive tests determine which most sensitive liability illness. Two hundred...
Abstract Functional alterations of components the endogenous cannabinoid system, in particular receptor 1 protein (CB1), are hypothetical contributors to many symptoms seen schizophrenia. Variants within gene (CNR1) have been shown be directly associated with hebephrenic form schizophrenia a Japanese population. This finding, however, has yet replicated. In present study we sought same (AAT)n‐repeat microsatellite CNR1 which showed association Japan, and investigate whether this type...
Schizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age of onset. In this study, the heritability, or proportion variation in onset psychotic symptoms due to genetic factors, was estimated using maximum likelihood method. The subjects were 717 members families more than one member affected schizophrenia from Mexican and Central American populations. Age psychosis determined by best-estimate consensus diagnosis based on Diagnostic...
Abstract Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular models psychiatric disorders that account a patient’s genetic background. Here, we conducted an RNA-sequencing profiling study hiPSC-derived cell lines from schizophrenia (SCZ) subjects, most which are multiplex family, population isolate Central Valley Costa Rica. hiPSCs, neural precursor cells, and cortical neurons derived six healthy controls seven SCZ subjects were generated using...
Clinical and epidemiological characteristics of diarrhea associated with Vibrio mimicus were identified in 33 hospitalized patients referred to the Costa Rican National Diagnostic Laboratory Network between 1991 1994. The relevant symptoms presented by included abundant watery diarrhea, vomiting, severe dehydration that required intravenous Dhaka solution 83% but not fever. Seroconversion against V. was demonstrated four patients, from whom acute- convalescent-phase sera obtained. Those did...
Bipolar disorder and alcohol use (AUD) have a high rate of comorbidity, more than 50% individuals with bipolar also receive diagnosis AUD in their lifetimes. Although both disorders are heritable, it is unclear if the same genetic factors mediate risk for AUD. We examined 733 Costa Rican from 61 pedigrees. Based on best estimate process, 32% sample met criteria disorder, 17% had lifetime diagnosis, nicotine dependence, 21% an anxiety disorder. AUD, dependence were relatively common among...
Abstract Background Evidence continues to accumulate regarding the potential long-term health consequences of COVID-19 in population. To distinguish between COVID-19-related symptoms and limitations from those caused by other conditions, it is essential compare cases with community controls using prospective data ensuring case-control status. The RESPIRA study addresses this need investigating lasting impact on Health-related Quality Life (HRQoL) symptomatology a population-based cohort...
Abstract Methionine sulfoxide reductase (MSRA) is an antioxidant enzyme implicated in protection against oxidative stress and protein maintenance. We have previously reported the association of marker D8S542, located within MSRA gene, with schizophrenia Central Valley Costa Rica (CVCR). By performing fine mapping analysis, we now identified a potential three‐marker at risk haplotype same CVCR sample, global P ‐value slightly above nominal significance ( = 0.0526). sequencing gene individuals...
Abstract The long‐standing concept that schizophrenia (SC) and bipolar disorder (BP) represent two distinct illnesses has been recently challenged by findings of overlap genetic susceptibility loci for these diseases. We report here the results a linkage disequilibrium (LD) analysis chromosome 18 utilizing subjects with SC from Central Valley Costa Rica. Evidence association ( P < 0.05) was obtained in three chromosomal regions: 18p11.31 (D18S63), 18q12.3 (D18S474), 18q22.3‐qter...
The importance of genetics in understanding the etiology mental illness has become increasingly clear recent years, as more evidence mounted that almost all neuropsychiatric disorders have a genetic component. It also clear, however, these are etiologically complex, and multiple environmental factors contribute to their makeup. So far, traditional linkage mapping studies not definitively identified specific disease genes for disorders, although some potential candidates been via methods...
Objective: The present study investigated a new set of families Latin American ancestry in order to detect the location genes predisposing schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed for 175 newly recruited with at least two siblings suffering from disorder. Best-estimate consensus procedures were used arrive diagnoses, nonparametric allele-sharing statistics calculated linkage. Results: Genome-wide significant evidence linkage phenotype DSM-IV or...
Objective: This study used the population of Central Valley Costa Rica (CVCR) and phenotyping strategies alternative to DSMIV classifications investigate association neuregulin 1 with schizophrenia. Method: Using 134 family trios a history psychosis, we genotyped six seven markers originally identified be associated schizophrenia in Iceland. Results: The Icelandic haplotype was not CVCR population. However, novel found overrepresented subjects functional psychosis (global P ‐value >...
Abstract Schizophrenia is a complex psychiatric disorder, likely to be caused in part by multiple genes. In this study, linkage analyses were performed identify chromosomal regions most associated with schizophrenia and psychosis multiplex families of Mexican Central American origin. Four hundred fifty‐nine individuals from 99 families, containing at least two siblings hospital diagnoses or schizoaffective genotyped. four microsatellite markers genotyped for all multipoint non‐parametric...