A5035930491- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Philosophical Thought and Analysis
- Genetic Syndromes and Imprinting
- Space Science and Extraterrestrial Life
- Critical Theory and Philosophy
- Mental Health Treatment and Access
- Genomic variations and chromosomal abnormalities
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Public Policy and Governance
- Political Dynamics in Latin America
- Personality Traits and Psychology
- Personality Disorders and Psychopathology
- Comparative constitutional jurisprudence studies
- World Systems and Global Transformations
- Perfectionism, Procrastination, Anxiety Studies
- Ion channel regulation and function
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Open Education and E-Learning
- Physical Education and Gymnastics
- Psychology Research and Bibliometrics
Universidad de Costa Rica
2010-2022
Instituto de Lengua Literatura y Antropología
2021
Universidad de Deusto
2012-2020
Texas Tech University
2011
Texas Tech University Health Sciences Center
2011
The University of Texas Health Science Center at San Antonio
2008-2010
Tribunal Electoral del Estado de México
1994
<h3>Context</h3> Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given predisposing may be transmitted without expression categorical clinical phenotype, a strategy for identifying risk is identify and map quantitative intermediate phenotypes or endophenotypes. <h3>Objective</h3> To adjudicate neurocognitive endophenotypes disorder. <h3>Design</h3> All participants underwent diagnostic interviews...
Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these would also be BD in the Latino American population. To identify such regions, we tested previously variants SC and ancestral haploblocks containing single nucleotide (SNPs) sample subjects BD.A total 2254 individuals were genotyped for 91 SNPs previous GWASs, along selected strong...
Objectives: Through recent genome‐wide association studies (GWASs), several groups have reported significant between variants in the calcium channel, voltage‐dependent, L‐type, alpha 1C subunit (CACNA1C) and bipolar disorder (BP) European European‐American cohorts. We performed a family‐based study to determine whether CACNA1C is associated with BP Latino population. Methods: This included 913 individuals from 215 pedigrees recruited USA, Mexico, Guatemala, Costa Rica. The Illumina...
Variations in circadian genes can impact biological rhythms. Given the rhythm disturbances that characterize bipolar disorder (BD), encoding components of molecular clocks are good candidate for illness.A family based association analysis gene single nucleotide polymorphisms (SNPs) and BD was conducted Latino pedigrees. 884 individuals from 207 pedigrees (473BP phenotype 411 unaffected members) were genotyped. Family marker testing performed. Ancestral haplotypes (SNPs found to be strong LD...
Depression and suicidal behavior are frequently observed in patients with schizophrenia. The serotonin transporter protein regulates serotonergic signaling at synapses is encoded by a single gene (SLC6A4; Locus Link ID: 6532), located 17q11.1-q12 two polymorphic variants (the short the long allele). allele of has been associated depression suicidality individuals who suffered negative life events chronic psychosis.. Subjects were recruited from genetic study schizophrenia conducted Costa...
Objective: Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression persons who have exposed a number of stressful life events. Method: We evaluated whether genetic variation 5‐HTTLPR, influences current depression, lifetime history and quantitative measures with chronic psychotic disorders. This is an association study variant categorical definitions conducted southwest US, Mexico Costa Rica. analyzed 260 subjects psychosis, from sample 129...
Abstract A genome‐wide nonparametric linkage screen was performed to localize Bipolar Disorder (BP) susceptibility loci in a sample of 3757 individuals Latino ancestry. The included 963 with BP phenotype (704 relative pairs) from 686 families recruited the US, Mexico, Costa Rica, and Guatemala. Non‐parametric analyses were over 5 cM grid an average genetic coverage 0.67 cM. Multipoint conducted across genome using non‐parametric Kong & Cox LOD scores along S all statistics for pairs....
We determined the rates of agreement between diagnoses, using Diagnostic Interview for Genetic Studies (DIGS) and diagnoses arrived at, additional sources information, to establish whether there are differences in direct interview at US non-US sites comparison best estimate consensus process identify that could increase diagnostic error when only DIGS is used. were compared with used same interview, plus Family (FIGS) review medical records 342 psychotic subjects. found similar numbers...
Abstract Tourette Syndrome (TS) is a heritable, early-onset neuropsychiatric disorder that typically begins in early childhood. Identifying rare genetic variants make significant contribution to risk affected families may provide important insights into the molecular aetiology of this complex and heterogeneous syndrome. Here we present whole-genome sequencing (WGS) analysis from 11-generation pedigree (>500 individuals) densely Costa Rican family which shares ancestry six founder pairs....
We previously identified bipolar disorder (BD) susceptibility loci on 8q24, 14q32, and 2q12‐14 in a genome‐wide nonparametric linkage screen Latino cohort. now perform fine mapping analysis using dense map of additional SNPs to identify BD genes within these regions. One thousand nine hundred thirty‐eight individuals with ancestry (880 Type I or Schizoaffective, Bipolar Type) from 416 pedigrees the United States, Mexico, Costa Rica, Guatemala were genotyped 3,074 provide coverage 8q24 (11.5...
Se ha evaluado el estado de conservación las marquesinas metálicas los andenes y terminal viajeros la estación ferrocarril Aranjuez. Los objetivos incluyen diagnosis procesos mecanismos deterioro, degradación corrosión que han tenido lugar, establecimiento criterios intervención, rehabilitación preventiva, adecuados para su correcta preservación. determinaron patologías macroscópicas microscópicas materiales metálicos que, por naturaleza protagonismo en marquesinas, poseen un considerable...