A5030987506- Sarcoma Diagnosis and Treatment
- Cancer-related gene regulation
- COVID-19 and Mental Health
- Psychological Well-being and Life Satisfaction
- Food Waste Reduction and Sustainability
- Genetics and Neurodevelopmental Disorders
- Head and Neck Surgical Oncology
- Urban Agriculture and Sustainability
- Congenital Heart Disease Studies
- Vascular anomalies and interventions
- Reconstructive Facial Surgery Techniques
- Ear Surgery and Otitis Media
- Nasal Surgery and Airway Studies
- Child Nutrition and Water Access
- Hearing, Cochlea, Tinnitus, Genetics
- Sleep and related disorders
- Service-Learning and Community Engagement
- Obesity, Physical Activity, Diet
- Child Nutrition and Feeding Issues
- Sinusitis and nasal conditions
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Antifungal resistance and susceptibility
- Viral Infections and Immunology Research
- Cardiac tumors and thrombi
Leiden University
2018-2024
Hague Institute for Global Justice
2018-2024
Maria Fertility Hospital
2023
Cancer Research Institute of the Slovak Academy of Sciences
2009-2023
University of Ulsan
2022
Asan Medical Center
2022
Stanford University
2021
Pusan National University Hospital
2011-2018
Yonsei University
2016-2018
The University of Texas Southwestern Medical Center
2018
Background: The coronavirus disease 2019 (COVID-19) pandemic has increased the already high levels of stress that higher education students experience. Stress influences health behaviors, including those related to dietary alcohol, and sleep; yet effects can be mitigated by resilience. To date, past research studying connections between alcohol misuse, sleep, resilience commonly investigated singular relationships two constructs. aim current study was explore these constructs in a more...
Obesity is a growing epidemic among university students, and the high levels of stress reported by this population could contribute to issue. Singular relationships between perceived stress; engagement in restrained, uncontrolled, emotional eating; sleep; dietary risk; body mass index (BMI) have been current literature; however, these constructs interact with each other, complex them are infrequently examined. Therefore, aim present study was explore using mediation moderation analyses...
Abstract Objective: This case‐control study aimed to analyze the effect of intratympanic dexamethasone injection (ITDI) as a treatment option for patients with sudden sensorineural hearing loss (SSNHL) who were refractory classic oral steroid treatment. Methods: Sixty‐six SSNHL, course therapy, included in this study. We prospectively treated consecutive 33 (34 ears) ITDI from August 2002 January 2004. then retrospectively collected data age‐ and sex‐matched previous did not take any more...
High levels of perceived stress and anxiety among university students are a global concern known to negatively influence sleep. However, few studies have explored how response styles, like psychological resilience rumination, might alter these relationships. Using validated tools, stress, anxiety, sleep behaviors undergraduate graduate from seven countries during the height COVID-19 pandemic were characterized in order examine relationships between factors using mediation moderation...
We intended to evaluate diagnostic utility of a targeted gene sequencing by using next generation (NGS) panel in patients with intractable early-onset epilepsy (EOE) and find the efficient analytical step for increasing diagnosis rate. assessed 74 EOE whose seizures started before 3 years age customized NGS that included 172 genes. Single nucleotide variants (SNVs) exonic chromosomal copy number variations (CNVs) were intensively examined our pipeline crosschecked commercial or pre-built...
Health behaviors of higher education students can be negatively influenced by stressful events. The global COVID-19 pandemic presents a unique opportunity to characterize and compare health across multiple countries examine how these are shaped the experience. Undergraduate graduate enrolled in universities China, Ireland, Malaysia, South Korea, Taiwan, Netherlands United States (USA) were recruited into this cross-sectional study. Eligible filled out an online survey comprised validated...
The COVID-19 pandemic has altered the landscape of higher education, forcing institutes across globe to lock down campuses and shift instructional methods. To determine impact these changes on students, 644 currently enrolled education students seven countries (USA, Netherlands, Ireland, South Korea, China, Malaysia, Taiwan) were asked report their pandemic-related concerns. Qualitative responses translated indexed by theme, with reporting major concerns in areas safety, mental health,...
Anatomical variations in the nose and paranasal sinuses are common children. Due to absence of a definitive relationship between anatomical sinus disease, local, systemic or environmental factors appear be more significant pediatric sinusitis than anatomic variations.Chronic is increasing population. Following initial reports functional endoscopic surgery (FESS) for children, majority patients undergoing this procedure have experienced improved quality life. Thus, we need know precise...
Abstract The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma childhood, yet outcome for unresectable and metastatic disease dismal unchanged nearly three decades. To better understand pathogenesis this to facilitate novel preclinical approaches, we previously developed a conditional mouse model ARMS by faithfully recapitulating genetic mutations observed in human disease, i.e., activation Pax3:Fkhr fusion gene with either p53 or...
This study was conducted to develop a smartphone application (app) as an educational learning instrument for coronary artery disease (CAD) patients and assess the users' level of satisfaction.This methodological research involves elicited content CAD using app. The app developed according steps Assessment, Design, Development, Implementation, Evaluation, which is systematic instructional design model. levels satisfaction with among 30 outpatients were assessed via questionnaire during their...
The first COVID-19 cases occurred in the US January of 2020, leading to implementation shelter place. This study seeks define impact place on epidemiology pediatric trauma.We examined trauma admissions at 5 Level 1 and 2 centers between June 30, 2017-2020. Demographic injury data were compared pre- post-shelter patient cohorts.A total 8772 activations reviewed. There was a 13% decrease volume with nadir 16 days following Injury severity scores higher cohort. incidence nonmotorized vehicle...
Abstract Background Tumor initiation has been attributed to haploinsufficiency at a single locus for large number of cancers. Patched1 ( Ptc1 ) was one the first such loci, and asserted lead medulloblastoma rhabdomyosarcoma in mice. Procedure To study role cerebellar tumor development create preclinical therapeutic platform, we have generated conditional model by inactivating Pax7 ‐expressing cells cerebellum. Results These mice developed exclusively medulloblastoma. We show that despite...
We investigated whether high-protein enteral nutrition with immune-modulating nutrients (IMHP) enriched β-glucan stimulates immune function in critically ill patients. In a randomized double-blind placebo-controlled study, 30 patients consumed one of three types nutrition: control or IMHP and without β-glucan. The group showed increases natural killer (NK) cell activities relative to the baseline, greater were observed NK after adjusting for age gender. groups had serum prealbumin decreases...
With rising obesity rates in children, it is increasingly difficult to differentiate between type 1 and 2 diabetes mellitus (T1DM, T2DM) on clinical grounds alone. Using C-peptide as a method of classifying (DM) has been suggested. This study aimed find correlation fasting level DM types children adolescents.A total 223 diabetic newly diagnosed at 5 hospitals January 2001 December 2012, were enrolled this study. Initial classification was based laboratory data including diagnosis; final...
Background and PurposeThe aim of this study was to determine the effectiveness stiripentol (STP) add-on therapy valproate clobazam in patients with Dravet syndrome (DS) according presence mutations sodium channel alpha-1 subunit gene (SC-N1A). MethodsWe performed direct sequencing analyze SCN1A 32 clinically confirmed DS, classified them into mutation (pathogenic or likely pathogenic) nonmutation groups based on American College Medical Genetics Genomics guidelines.We compared efficacy STP...
Community Based Health Insurance (CBHI) schemes have become central to health systems financing as avenues of achieving universal coverage in developing countries. Yet, while emphasis research and policy has mainly concentrated on enrolment, very little been apportioned high rates dropping out after initial enrolment. The main aim this study is understand the factors behind CBHI through a cross-sectional quantitative design gain insights into curtailing drop Uganda.The survey for component...
To evaluate and systemize intraoperative facial nerve monitoring (IOFNM) in middle ear mastoid surgeries.A prospective study.IOFNM was performed 100 patients undergoing surgeries. We checked "surgical dehiscence" under microscopes, also estimated the minimal threshold of electric current needed to change electromyography muscles using Nerve Integrity Monitor (NIM)-2 (Xomed, Minneapolis, MN, USA).Forty-three percent cases showed responded stimulation 0.7 mA or less. "Electrical (<or=0.7 mA)...
The present study prospectively investigated the frequencies and characteristics of audio-vestibular disturbance results audiologic vestibular function tests in patients with Behçet's disease.A prospective study.Seventeen disease (mean age 41.2 [30-56] years, 5 males 12 females), as well age- sex-matched healthy controls, were included this study. All subjects satisfied diagnostic criteria International Study Group for Disease. Information on was obtained through questionnaires. Tests,...
A newborn infant was evaluated because of a large cystic mass adjacent to the left atrium on prenatal ultrasound. The diagnosis an aneurysm atrial appendage. Most cases this rare lesion are recognized between 2nd and 4th decades life. present case, however, detected fetal echocardiography. patient showed significant mitral regurgitation caused by compression atrioventricular groove. Simple aneurysmectomy without valvuloplasty sufficient relieve in case.
[Purpose] Although the Push-Up Plus is a useful exercise method for shoulder stabilization, few studies have examined its effects at different angles of rotation. Therefore, present study investigated most effective stabilization by analyzing muscle activities rotator cuff muscles [Subjects] Fifteen healthy university students in their 20s were subjects this study. [Methods] Changes EMG related to analyzed performing positions neutral, internal and external [Results] The highest activity was...
Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which specific to chronic myeloid leukemia (CML), and c-transmembrane receptor, gastrointestinal stromal tumors. Interstitial pneumonitis rare adverse event imatinib therapy. It clinically difficult distinguish from infectious pneumonia, can frequently occur due underlying disease. The standard treatment for imatinib-induced discontinue medication optionally administer...
Background and aim Informal food establishments are an important source of due to their increased affordability products convenience. Food security safety two key factors that must coexist for a proper functioning the system. In Latin America, is less analyzed than security, although it central people’s health, as well personal sustainability. Since informal popular sources in this research aims examine presence foodborne pathogens from such establishments. Methods This will be conducted...
Urban households are an intimate nexus of food and waste, connecting people to challenges sustainability inequality, in wider systems. Household waste (HFW) studies, including those which explored consumption practices during COVID-19, have tended emphasize the reduction as part behaviour change. In 2018/19 exploratory, interdisciplinary, mixed method study was conducted HFW perceptions urban residents The Hague (Netherlands) with purposeful sampling (n = 19), speaking either Dutch, English...
Clinical features of acute myocarditis range from a subclinical state to fulminant state. Fulminant with ventricular arrhythmia or atrioventricular block is associated high mortality rate. In cases in which aggressive medical therapy for not likely be successful, intensive and emergency mechanical circulatory support, such as extracorporeal membrane oxygenation (ECMO) intra-aortic balloon pump, should considered. We report life salvage 53-year-old woman presented malignant cardiogenic shock...
Schizophrenia is the most devastating mental illness that causes severe deterioration in social and occupational functioning. This a pilot study for family-based association analysis of schizophrenia Korean population to search candidate genes functionally relevant positionally on chromosome 18.We have recruited 27 probands (with psychosis) with their parents siblings whenever possible. We analyzed 20 SNPs (Single Nucleotide Polymorphism) seven neuronal 18 DNA samples was checked data...