Chang‐Chi Lai

ORCID: 0000-0003-0453-1207
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About
Contact & Profiles
Research Areas
  • Cardiac Ischemia and Reperfusion
  • COVID-19 and Mental Health
  • Anesthesia and Neurotoxicity Research
  • Cardiac Arrest and Resuscitation
  • Psychological Well-being and Life Satisfaction
  • Flavonoids in Medical Research
  • Mitochondrial Function and Pathology
  • Acute Kidney Injury Research
  • Muscle metabolism and nutrition
  • Eicosanoids and Hypertension Pharmacology
  • Macrophage Migration Inhibitory Factor
  • Advanced Glycation End Products research
  • Cardiovascular and exercise physiology
  • Sports Performance and Training
  • Cell death mechanisms and regulation
  • Exercise and Physiological Responses
  • Magnolia and Illicium research
  • Sleep and related disorders
  • Cardiovascular Function and Risk Factors
  • Genetics and Physical Performance
  • Neurological Disease Mechanisms and Treatments
  • Traditional Chinese Medicine Analysis
  • Cardiovascular Effects of Exercise
  • Thin-Film Transistor Technologies
  • Bee Products Chemical Analysis

University of Taipei
2015-2024

National Yang Ming Chiao Tung University
2013-2022

Taipei Veterans General Hospital
2013-2022

National Yang Ming University Hospital
2017

Ming Chuan University
2015

National Science and Technology Council
2010

National Taiwan University
2010

Background: The coronavirus disease 2019 (COVID-19) pandemic has increased the already high levels of stress that higher education students experience. Stress influences health behaviors, including those related to dietary alcohol, and sleep; yet effects can be mitigated by resilience. To date, past research studying connections between alcohol misuse, sleep, resilience commonly investigated singular relationships two constructs. aim current study was explore these constructs in a more...

10.3390/nu13020442 article EN Nutrients 2021-01-29

High levels of perceived stress and anxiety among university students are a global concern known to negatively influence sleep. However, few studies have explored how response styles, like psychological resilience rumination, might alter these relationships. Using validated tools, stress, anxiety, sleep behaviors undergraduate graduate from seven countries during the height COVID-19 pandemic were characterized in order examine relationships between factors using mediation moderation...

10.3390/clockssleep2030025 article EN cc-by Clocks & Sleep 2020-08-11

Health behaviors of higher education students can be negatively influenced by stressful events. The global COVID-19 pandemic presents a unique opportunity to characterize and compare health across multiple countries examine how these are shaped the experience. Undergraduate graduate enrolled in universities China, Ireland, Malaysia, South Korea, Taiwan, Netherlands United States (USA) were recruited into this cross-sectional study. Eligible filled out an online survey comprised validated...

10.3390/clockssleep3010002 article EN cc-by Clocks & Sleep 2021-01-15

The COVID-19 pandemic has altered the landscape of higher education, forcing institutes across globe to lock down campuses and shift instructional methods. To determine impact these changes on students, 644 currently enrolled education students seven countries (USA, Netherlands, Ireland, South Korea, China, Malaysia, Taiwan) were asked report their pandemic-related concerns. Qualitative responses translated indexed by theme, with reporting major concerns in areas safety, mental health,...

10.37074/jalt.2021.4.1.10 article EN Journal of Applied Learning & Teaching 2021-03-25

Kinesiology taping (KT) is widely used to support muscle function and recovery, but its optimal application timing remains unclear. While some suggest pre-exercise KT provides protective benefits, others propose post-exercise aids recovery. Eccentric contractions often lead eccentric exercise-induced damage (EIMD), causing strength loss, soreness, reduced range of motion. Whether influences effectiveness in mitigating or accelerating EIMD recovery requires further investigation. This study...

10.3389/fphys.2025.1588339 article EN cc-by Frontiers in Physiology 2025-04-28

Baicalein is an active component of Scutellaria baicalensis Georgi, which has traditionally been used to treat cardiovascular diseases in China. In this study, we investigated if treatment with baicalein can attenuate the lung injury induced by myocardial ischemia and reperfusion (I/R). Myocardial I/R, a 40-min occlusion left anterior descending coronary artery 3-h reperfusion, significantly increased histological damage wet-to-dry weight ratio lungs rats. The terminal deoxynucleotidyl...

10.1142/s0192415x17500422 article EN The American Journal of Chinese Medicine 2017-01-01

Acute kidney injury is a common and serious complication of cardiac surgery. Because its underlying mechanisms are unclear, there no specific therapy to prevent or treat it. A regional transient ischaemia reperfusion (I/R) may provide protection distant tissue organs, phenomenon known as remote preconditioning. In this study, we investigated whether myocardial preconditioning (MPC) would reduce apoptosis induced by I/R, well the involved.Myocardial I/R was 40-min occlusion left anterior...

10.1093/ejcts/ezu453 article EN European Journal of Cardio-Thoracic Surgery 2014-12-04

Magnolol, a constituent of the bark Magnolia officinalis, has been reported to decrease myocardial stunning and infarct size. In this study, we investigated whether magnolol can reduce renal ischemia reperfusion (I/R) injury. Renal I/R, induced by 60-min occlusion bilateral arteries 24-h reperfusion, significantly increased blood urea nitrogen (BUN) creatinine levels, caused histological damage kidneys rats. Apoptosis, as evaluated terminal deoxynucleotidyl transferase-mediated dUTP nick-end...

10.1142/s0192415x1750077x article EN The American Journal of Chinese Medicine 2017-01-01

Acute kidney injury is a common and severe complication of acute myocardial infarction cardiac surgery. It results in increased mortality, morbidity, duration hospitalization. Baicalein component the root <i>Scutellaria baicalensis</i>, which has traditionally been used to treat cardiovascular liver diseases Asia. In this study, we investigated whether baicalein can attenuate induced by ischemia reperfusion rats. Myocardial reperfusion, 40-minute occlusion 3-hour left anterior descending...

10.1055/s-0035-1558114 article EN Planta Medica 2015-11-09

A half-marathon (HM) is a vigorous high-intensity exercise, which could induce lower extremity musculoskeletal injury risks for recreational runners. They usually consume nonsteroidal anti-inflammatory drugs (NSAIDs) in order to shorten their return play but ignore the side effects, such as peptic ulcers and renal vascular disorders. Lactobacillus plantarum PS128 (PS128) improve inflammation oxidative stress by modulating gut microbiota, thus potentially improving muscle damage recovery....

10.3390/nu13114023 article EN Nutrients 2021-11-11

Baicalein is a component of the root Scutellaria baicalensis Georgi, which has traditionally been used to treat liver disease in China. In present study, we investigated baicalein’ ability reduce injury induced by myocardial ischemia and reperfusion (I/R). Myocardial I/R was this experiment 40[Formula: see text]min occlusion left anterior descending coronary artery 3[Formula: text]h rats. The significantly increased serum levels aspartate transaminase (AST) alanine (ALT), indicating presence...

10.1142/s0192415x16500294 article EN The American Journal of Chinese Medicine 2016-01-01

(1) Background: Years of research have identified ischemic preconditioning (IPC) as a crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury, enhancing the cell’s tolerance to subsequent damage. High-intensity interval training (HIIT) is promoted by athletes because it reduces exercise duration and improves metabolic response cardiopulmonary function. Our objective was evaluate compare whether HIIT IPC could reduce ischemia reperfusion injury in rats. (2)...

10.3390/life14030310 article EN cc-by Life 2024-02-27

TNF-α plays critical roles in bone-resorbing diseases, such as rheumatoid arthritis. Recent evidence suggests that thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor γ agonists, have anti-inflammatory effects. The aim of this study was to evaluate the effect TZDs on TNF-α-mediated osteoclastogenesis osteoclast precursor cells. treatment RAW264.7 murine macrophages or mouse bone marrow cells induced significant multinuclear formation, and these differentiated...

10.1097/shk.0b013e3181cc0738 article EN Shock 2010-03-23

Ischemic preconditioning has been reported to protect the myocardium against ischemia and reperfusion injury. The underlying mechanisms have extensively investigated but are not fully elucidated. In this study, we role of apoptosis in ischemic protection signal pathways involved.Myocardial were induced anesthetized male Sprague-Dawley rats by a 40-minute occlusion 3-hour left anterior descending coronary artery. was elicited two 10-minute artery occlusions reperfusions.The myocardial infarct...

10.1016/j.jcma.2015.04.006 article EN publisher-specific-oa Journal of the Chinese Medical Association 2015-06-13

Swimming is important for promoting and maintaining health, as it can increase the efficiency of cardiovascular system decrease occurrence diseases. The objective present study was to examine whether swimming training could myocardial injury in rats caused by ischemia/reperfusion (I/R). Sprague-Dawley were randomized into four groups, namely Sham, coronary artery occlusion, ischemic preconditioning (IPC) groups. Myocardial I/R induced anesthetized male a 40-min occlusion followed 3-h...

10.3892/br.2022.1502 article EN Biomedical Reports 2022-01-31

Introduction:Lactobacillus plantarum PS128 (PS128) could be considered an antioxidant supplement to reduce muscle fatigue and improve exercise capacity recovery after vigorous exercise. Purpose: The purpose of this study is investigate the effect on electromyography (EMG) activity a half-marathon (HM). Methods: experimental design used repeated-measures with double-blind approach. participants either took two capsules for 4 weeks as group (PSG, n = 8) or placebo (PLG, ensure...

10.3389/fphys.2023.1254985 article EN cc-by Frontiers in Physiology 2023-11-30

Introduction Adequate water intake is a low-cost and effectively non-invasive strategy for individual health outcomes. We aimed to demonstrate the efficacy of intervention in intensive-labor static-type workplaces. Method Smart drinking cups were provided participants, built-in application (App) associated with cup was downloaded on their phones. The App collected recorded amount consumed by participants set reminders education information. assessed data, including time interval between...

10.1177/00469580221085778 article EN INQUIRY The Journal of Health Care Organization Provision and Financing 2022-01-01

We previously reported that pressure overload of the left ventricle reduced myocardial infarct (MI) size in rabbits. The threshold was investigated this study.Pressure induced by partial snare ascending aorta anesthetized, open-chest Systolic ventricular (SLVP) elevated 50% or 30% above baseline value varying degree snaring. Different duration overload, including 10 minutes, 5 3 2 applied to determine protective effects. Ischemic preconditioning elicited two 10-minute coronary artery...

10.1016/j.jcma.2013.05.005 article EN publisher-specific-oa Journal of the Chinese Medical Association 2013-06-14

Background: Magnolol is a component of the bark Magnolia officinalis , which traditional herbal remedy used in China. In this study, we investigated whether magnolol can reduce myocardial injury induced by renal ischemia and reperfusion (I/R). Methods: Renal I/R was elicited 60-minute occlusion bilateral arteries 24-hour Sprague-Dawley rats. administered intravenously 10 minutes before to evaluate its effects on I/R. Results: significantly increased serum levels creatine phosphokinase (CPK),...

10.1097/jcma.0000000000000727 article EN cc-by-nc-nd Journal of the Chinese Medical Association 2022-04-06

Background: High-intensity interval training (HIIT) has been recognized as an effective form of short-duration exercise. The purpose this study was to assess whether HIIT could reduce renal injury induced by myocardial ischemia-reperfusion (MIR) in rats. Methods: Male Sprague-Dawley rats were randomly assigned the Sham (SHAM), coronary artery occlusion (CAO), HIIT, and ischemic precondition (IPC) groups. Rats underwent 40 minutes left anterior descending CAO under anesthesia, followed 3...

10.1097/jcma.0000000000001183 article EN cc-by-nc-nd Journal of the Chinese Medical Association 2024-10-22

The instantaneous switch-off of the gas precursors during ramp-down cycle in a spike ramp process is demonstrated to be an effective method enhance reliability rapid thermal oxide. Due slow rate (60/spl deg/C-90/spl deg/C/s) process, oxidation may produce inferior oxide, especially for ultrathin To avoid cycle, precursor (oxygen) switched off cycle. resulting oxide without enhanced as compared with conventional which still oxidized

10.1109/tsm.2003.818982 article EN IEEE Transactions on Semiconductor Manufacturing 2003-11-01

Background We have previously reported that brief pressure overload of the left ventricle reduced myocardial infarct (MI) size. However, role protein kinase C (PKC) remains uncertain. In this study, we investigated whether reduces MI size by activating PKC. Methods was induced a 40-minute occlusion anterior descending coronary artery and 3-hour reperfusion in anesthetized Sprague-Dawley rats. determined using triphenyl tetrazolium chloride staining. Brief achieved two 10-minute partial...

10.1016/j.jcma.2015.05.004 article EN Journal of the Chinese Medical Association 2015-06-13
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