A5103212155- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Geotechnical Engineering and Underground Structures
- Parasites and Host Interactions
- Toxoplasma gondii Research Studies
- Blood Pressure and Hypertension Studies
- Leptospirosis research and findings
- Aquatic Ecosystems and Phytoplankton Dynamics
- Yersinia bacterium, plague, ectoparasites research
- Insect symbiosis and bacterial influences
- Vector-Borne Animal Diseases
- Toxin Mechanisms and Immunotoxins
- Insect Pest Control Strategies
- Seismic Performance and Analysis
- Geotechnical Engineering and Soil Mechanics
- Parasite Biology and Host Interactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Fish Ecology and Management Studies
- Physiological and biochemical adaptations
- Geotechnical Engineering and Soil Stabilization
- Cardiovascular Health and Disease Prevention
- Parasitic Infections and Diagnostics
- Tuberculosis Research and Epidemiology
NovaMechanics (Cyprus)
2023-2024
Cyprus Institute
2024
University of Crete
2014-2023
ETH Zurich
2019-2023
University of Lausanne
2020-2023
Cyprus University of Technology
2022
Cyprus Research and Innovation Center (Cyprus)
2022
Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety
2020
University Hospital of Lausanne
2020
National Centre of Scientific Research "Demokritos"
2020
Background The recent geographical expansion of phlebotomine vectors Leishmania infantum in the Mediterranean subregion has been attributed to ongoing climate changes. At these latitudes, activity sand flies is typically seasonal; because seasonal phenomena are also sensitive general variations climate, current phenological data sets can provide a baseline for continuing investigations on fly population dynamics that may impact future scenarios leishmaniasis transmission. With this aim,...
Background. A large outbreak of hepatitis affected individuals in several Australian states 2009, resulting a 2-fold increase cases reported to state health departments compared with 2008. Two peaks infection occurred (April–May and September–November), surveillance data suggesting locally acquired infections from widely distributed food product.
Protozoan parasites of the genus Leishmania adapt to environmental change through chromosome and gene copy number variations. Only little is known about external or intrinsic factors that govern genomic adaptation. Here, by conducting longitudinal genome analyses 10 new clinical isolates, we uncovered important differences in among genetically highly related strains revealed gain loss copies as potential drivers long-term adaptation field. In contrast, rather than amplification was...
The rapid advance of nanotechnology has led to the development and widespread application nanomaterials, raising concerns regarding their potential adverse effects on human health environment. Traditional (experimental) methods for assessing nanoparticles (NPs) safety are time-consuming, expensive, resource-intensive, raise ethical due reliance animals. To address these challenges, we propose an in silico workflow that serves as alternative or complementary approach conventional hazard risk...
Phlebotomine sand flies are incriminated in the transmission of several human and veterinary pathogens. To elucidate their role as vectors, proper species identification is crucial. Since traditional morphological determination based on minute often dubious characteristics head genitalia, which require certain expertise may be damaged field-collected material, there a demand for rapid, simple cost-effective molecular approaches. Six laboratory-reared colonies phlebotomine belonging to five...
In Cyprus, leishmaniasis has been considered exclusively a veterinary problem. It was prevalent before 1945, and until its recent reemergence, it nearly eradicated by 1996 as consequence of the destruction reservoir hosts vectors. A survey carried out to provide an unbiased estimate current transmission rates in dogs humans showed 9-fold increase dog seroprevalence (reaching 14.9%) compared with 10 years ago. However, no human cases caused Leishmania infantum were detected, although L....
Blood-sucking phlebotomine sand flies are the vectors of protozoan parasites Leishmania spp. Different Phlebotomus species transmit different causing leishmaniases which neglected diseases emerging/reemerging in new regions. Thirteen fly species, ten belonging to medically important genus and three Sergentomyia known Greece. An increasing number human dog cases reported each year from all parts country including Aegean Islands. However, no previous study has been conducted on fauna islands,...
This paper proposes a new set of scaling laws for the study post-cracking behaviour lightly reinforced concrete tunnel linings during 1g shaking table testing. The are formulated using two non-dimensional parameters: brittleness number s, which governs fracturing phenomenon unreinforced elements and NP, plays primary role stability process fracture steel plastic flow in elements. proposed allow development an "adequate" experimental model validated numerical analyses rock, both prototype...
The paper studies the performance of Offshore Wind Turbines (OWTs) founded on Suction Bucket Jackets (SBJs) in clay under combined wind and seismic loading. A detailed 3D FE model soil–foundation–structure (SFS) system is developed used as a benchmark to assess efficiency an enhanced Winkler-based "Caisson-on-Winkler-Soil" (CWS) model, where soil replaced by nonlinear hysteretic elements. proposed CWS captures residual deformations hysteresis offers physical coupling between vertical moment...
A total of 622 rats (402 Rattus norvegicus and 220 R. rattus frugivorus) were collected in 51 different areas Cyprus during 2000–2003 used as indicators the presence dispersal six zoonotic microbial agents. IgG antibodies against Rickettsia typhi (241/496, 48.6%), conorii (209/500, 41.8%), Toxoplasma sp. (138/494, 27.9%), Coxiella burnetti (63/494, 12.8%), Bartonella henselae (52/494, 10.5%) Leishmania infantum (36/494, 7.3%) detected by indirect immunofluorescence test. There was variation...
Leishmaniases are vector-borne diseases transmitted by phlebotomine sand flies. Three species of Leishmania found in the Mediterranean basin: infantum, most common responsible for both visceral (VL) and cutaneous leishmaniasis (CL); major, North Africa Middle East causing CL; tropica with a limited presence Europe, CL. During last 25 years, Crete has become an endemic zone L. infantum high number infected dogs increasing human cases every year; 4 incidence reached average seven VL patients...
Phleboviruses transmitted by sandflies are endemic in the Mediterranean area. The last decade has witnessed description of an accumulating number novel viruses. Although, risk exposure vertebrates is globally assessed, detailed geographic knowledge poor even Greece and Cyprus where sandfly fever been recognized for a long time repeatedly. A total 1,250 dogs from mainland Greek archipelago on one hand 422 other have sampled tested neutralising antibodies against Toscana virus (TOSV), Sandfly...
Fleas collected from rats during a three-year period (2000–2003) in 51 areas of all provinces Cyprus were tested by molecular analysis to characterize the prevalence and identity fleaborne rickettsiae. Rickettsia typhi , causative agent murine typhus, was detected Xenopsylla cheopis (4%) Leptopsylla segnis (6.6%). felis X. (1%). This is first report R. L. rats, Cyprus, Europe. The role fleas (mainly ) confirmed epidemiologic cycle typhus interrelation current results with those previous...
Abstract Background The dynamic re-emergence of visceral leishmaniasis (VL) in south Europe and the northward shift to Leishmania -free European countries are well-documented. However, epidemiology VL due infantum southeastern (SE) Balkans is inadequately examined. Herein, we aim re-evaluate compare population structure L. SE southwestern (SW) Europe. Methods strains collected from humans canines Turkey, Cyprus, Bulgaria, Greece, Albania Croatia, were characterized by K26 -PCR assay...
Detection and quantification of pathogen-derived antigenic structures is a key method for the initial diagnosis follow-up various infectious diseases. Complex parasitic diseases such as leishmaniasis require highly sensitive specific tests prior to treatment with potentially toxic drugs. To investigate diagnostic potential cell surface glycans found on Leishmania parasites, we identified diagnostically relevant glycan epitopes used synthetic microarrays screen sera from infected humans dogs....
Abstract The development of optical biosensors based on silicon dioxide or nitride transducers requires the chemical activation their surface to achieve stable, repeatable and homogeneous binding biomolecules. In present study, surfaces with 3‐aminopropyl‐triethoxysilane (APTES) was optimized so as enable immobilization biomolecules by adsorption covalent bonding. Chemical performed either aqueous organic solution APTES, were used immobilize directly protein molecules physical further...