A5047678943- Lymphatic System and Diseases
- Vascular Malformations and Hemangiomas
- Lymphatic Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reconstructive Facial Surgery Techniques
- Tumors and Oncological Cases
- Diagnosis and Treatment of Venous Diseases
- Vascular Tumors and Angiosarcomas
- Vascular anomalies and interventions
- Teratomas and Epidermoid Cysts
- Cleft Lip and Palate Research
- Streptococcal Infections and Treatments
- Surgical Simulation and Training
- Tuberculosis Research and Epidemiology
- Vascular Procedures and Complications
- CAR-T cell therapy research
- Trauma Management and Diagnosis
- Pregnancy and preeclampsia studies
- Reproductive Health and Technologies
- Central Venous Catheters and Hemodialysis
- Hydrogels: synthesis, properties, applications
- Electrospun Nanofibers in Biomedical Applications
- Pregnancy and Medication Impact
Okayama University Hospital
2025
Okayama University
2014-2024
Saitama Children's Medical Center
2017-2023
The University of Tokyo
2014-2023
University of Tokyo Hospital
2015-2023
Creative Commons
2017-2022
Asahi General Hospital
2018-2020
Saitama Prefecture
2020
Social Insurance Saitama Chuo Hospital
2019
Children's Medical Center
2019
Intractable vascular anomalies (VAs), including tumors and venous, lymphatic, mixed malformations, often have severe symptoms a poor prognosis, highlighting the need for new treatments. We conducted prospective trial of sirolimus (tablet granule forms) treatment VAs. In this open-label, single-arm, multicenter across four Japanese institutions, patients with VAs received oral daily, targeting trough concentration 5-15 ng/mL. evaluated response rates (radiological volume changes in lesions),...
A lymphangioma, also called a lymphatic malformation, is congenital condition that frequently occurs in young children. It classified into 3 groups depending on the size of cysts (macrocystic, microcystic, and mixed). Spontaneous regression some cases; however, characteristics patients who show have not been studied previously. Furthermore, types timing initial treatment are still controversial. Therefore, we statistically analyzed occurrence short-term spontaneous regression, patient age at...
Abstract The adeno-associated virus (AAV) is a potent vector for in vivo gene transduction and local therapeutic applications of AAVs, such as skin ulcers, are expected. Localization expression important the safety efficiency genetic therapies. We hypothesized that could be localized by designing biomaterials using poly(ethylene glycol) (PEG) carrier. Here we show one designed PEG carriers effectively on ulcer surface reduced off-target effects deep layer liver, representative organ to...
Abstract Orbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnormally dilated channels. Here, we identify somatic missense mutation, c.121G > T (p.Gly41Cys) in GJA4 , which encodes transmembrane protein that component gap junctions and hemichannels the system, OCVM tissues from 25/26 (96.2%) individuals with OCVM. expression was detected tissue including endothelial cells stroma, through immunohistochemistry. Within tissue,...
Four-armed poly(ethylene glycol) (PEG)s are essential hydrophilic polymers extensively utilized to prepare PEG hydrogels, which valuable tissue scaffolds. When hydrogels used in vivo, they eventually dissociate due cleavage of the backbone structure. occurs at cross-linking point, hydrogel elutes as an original polymer unit, i.e., four-armed PEG. Although PEGs have been subcutaneously implanted biomaterials, diffusion, biodistribution, and clearance behavior from skin not fully understood....
Free flap reconstruction of the foot and ankle can be challenging in that it must fulfill functional esthetic demands. Injury this region is often associated with fractures, muscle flaps are sometimes preferred. Here we present a case use superficial circumflex iliac artery (SCIA) chimeric for complex wound. A 78-year-old lady sustained open fractures left distal tibia, fibula, talus, 10 × 6 cm2 soft-tissue defect over lateral aspect her due to an automobile accident. 7 3 sartorius component...
Indocyanine green lymphography has recently been used to assess lymphatic vessel function in lymphedema patients. Postoperative collateral vessels toward ipsilateral axillary lymph nodes are rarely seen above the umbilical level lower Between January 2012 and December 2014, we performed indocyanine of 192 limbs 96 extremity cases. As a result, dermal back flow appeared 95 cases, with 38 abdominal area 31 genital area. We confirmed 3 cases superficial ways extending nodes. All had similarity...
Lymphatic malformation is a congenital lymphatic disorder. Although few lymphangiographic and lymphoscintigraphic studies of exist, its flow has not been fully assessed, classification system yet established. However, indocyanine green lymphography developed to safely provide fine assessment lymph in the treatment lymphedema. In addition, shown be helpful detecting inflow for refractory microcystic type using venous anastomosis technique. Therefore, authors aimed reveal vivo around...
The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment lymphedema, it hardly described a LM. Virtual reality ability to visualize human three dimensions can be used preoperative planning cases. Here, we describe first case LM by LVA preoperatively planned with virtual reality. A young woman presented...
Cases of dermoid cysts the auricle are presumed to be quite rare. We report such a case and make references 10 previously reported cases. It is important treat tumour in auricular area at an early stage prevent it from transforming into malignancy.
Abstract Background The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements PF various types defects are controversial. Here, we classify three and discuss the their functional prognosis. Methods Reconstruction was performed based on classification defects. Clinical details were collected, postoperative function analyzed. Results Eight patients included in study. defect sizes ranged from 25 (width) × 40 (depth) to 60 mm. Six underwent with...
The placenta is a major source of tumor necrosis factor-alpha (TNF alpha) and rich in TNF alpha receptors. inhibited hCG secretion by normal chorionic villi at 6 weeks gestation, but contain the heterogenous cell population. To investigate direct effects on trophoblasts, NUC1 choriocarcinoma line was used as an vitro placental model. also cells concentrations from 1-100 U/mL. 1, 10, 100 U/mL significantly decreased for 24 h to 88%, 81%, 71% control level, respectively. expression beta mRNA...
Lymphatic malformation (LM), also known as lymphangioma, is a rare condition that can occur anywhere in the body adults and children. LM, especially micro-cystic type, consists of multiple clustering skin/subcutaneous cysts may involve deeper functional tissue. Although LM generally benign, it cause serious location-dependent problems. Periorbital for example, often causes facial disfigurement visual impairment. Especially, type lymphatic (mLM), challenging to treat. Currently available...
Background: Less-invasive surgeries, such as lymphaticovenular anastomosis (LVA), are the widely accepted intervention for lymphedema. This study aimed to assess outcomes of flow-oriented LVA modification on lymphatic malformation (LM). Methods: We included 19 patients diagnosed with LM mixed type or microcystic type, who came our clinic from June 2015 December 2017. Under general anesthesia, all were administered an indocyanine green lymphography injection subcutaneously. In case a strong...
Klippel-Trenaunay syndrome (KTS) is a congenital vascular anomaly in children, which requires treatment but challenging. The characteristics of KTS include disproportionality the affected limbs, usually with enlargement due to lymphatic malformation (LM) [1]. Sometimes condition accompanied by pain that difficult treat. Compression therapy one option for reducing swelling; however, this has limitations [2]. We previously reported venous anastomosis (LVA) may be safe and effective procedure...
Cleft lip and palate repair requires a deep small surgical field is usually performed by surgeons wearing loupes. Surgeons with loupes can obtain wider view, although headlights are required for the deepest procedures. Surgical microscopes offer comfort clear magnification-adjustable site that be shared whole team, including observers, easily recorded to further education of junior surgeons. Magnification adjustments convenient precise procedures such as muscle dissection soft palate.We...
Abstract Nipple adenoma is an uncommon proliferative process of the breast and predominantly occurs in women aged 40‐50. Its incidence extremely low men, it has not been reported a boy. Although nipple rare benign, being familiar with important because clinically resembles Paget disease histologically adenocarcinoma. We report case
Frontonasal dysplasia (FND) is a congenital malformation of the central portion face, including eyes, nose, and forehead. Owing to its rarity wide spectrum phenotypes, optimal timing technique surgery remain controversial. Here, we report case patient with FND, who presented respiratory distress. The deformed nostrils were so small that could not normally breathe through nose immediately after birth. Rhinoplasty using costochondral graft was performed at 16 months age. After surgery,...