A5103206473- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Metabolism and Genetic Disorders
- Transplantation: Methods and Outcomes
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Abdominal vascular conditions and treatments
- Drug Transport and Resistance Mechanisms
- Clinical Nutrition and Gastroenterology
- Pancreatic function and diabetes
- Congenital Heart Disease Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Glycogen Storage Diseases and Myoclonus
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Polyomavirus and related diseases
- Metastasis and carcinoma case studies
- Biochemical effects in animals
Asahi General Hospital
2019
National Center For Child Health and Development
2009-2018
Kyoto University
2012-2015
In-Q-Tel
2014
Tokyo National Hospital
2014
University Hospital of Basel
2013
Klinikum Ludwigshafen
2013
Stiftung Institut für Herzinfarktforschung
2013
Yokosuka Kyosai Hospital
2013
NHS Blood and Transplant
2011
Kasahara M, Sakamoto S, Kanazawa H, Karaki C, Kakiuchi T, Shigeta Fukuda A, Kosaki R, Nakazawa Ishige Nagao Shigematsu Y, Yorifuji Naiki Horikawa R. Living‐donor liver transplantation for propionic acidemia. Abstract: Propionic acidemia is a rare autosomal recessive disorder affecting the catabolism of branched‐chain amino acids because genetic defect in PCC. Despite improvements medical treatment with protein restriction, sufficient caloric intake, supplementation l ‐carnitine, and...
Background In the setting of liver transplantation in small infants who receive left lateral segment (LLS) grafts, problems are encountered related to graft-size mismatching form so-called “large-for-size” grafts. To address these problems, feasibility further reducing size LLS grafts hyperreduced (HRLLS) was investigated. Methods Of 175 pediatric living-donor transplantations performed between November 2005 and December 2011 at our institute, 31 cases were using HRLLS The medical records...
Luminal preservation of the intestine is an attractive method to locally mitigate injury and ischemic-reperfusion in small bowel transplantation (SBT) because this has a potential maintain intestinal graft integrity. Hydrogen noted as antioxidant material by reducing hydroxyl radicals. We hypothesized that hydrogen-containing solution can be optimum for luminal SBT.Ischemic reperfusion was induced Lewis rats occlusion supramesenteric artery vein 90 min. Experimental protocols were divided...
Liver transplantation is now an established treatment for children with end-stage liver disease. Left lateral segment (LLS) grafts are most commonly used in split and living donor children. In very small children, LLS can be too large, further nonanatomical reduction has recently been introduced to mitigate the problem of large-for-size grafts. However, implantation a infants because thickness grafts, these techniques do not address problems related thickness. We herein describe technique...
Abstract LT for PFIC type 1 is often complicated by postoperative diarrhea and recurrent graft steatosis. A 26‐month‐old female child with cholestatic jaundice, pruritus, diarrhea, growth retardation revealed total bilirubin 9.1 mg/dL, gamma‐glutamyl transpeptidase 64 IU /L, TBA 295.8 μmol/L. Genetic analysis confirmed ATP 8B1 defects. (segment 2, 3 graft) from the heterozygous father was performed. Biliary diversion performed a 35‐cm jejunum conduit between hepatic duct mid‐transverse...
Shigeta T, Kasahara M, Kimura Fukuda A, Sasaki K, Arai Nakagawa S, Kobayashi Soneda Kitagawa H. Liver transplantation for an infant with neonatal intrahepatic cholestasis caused by citrin deficiency using heterozygote living donor. Pediatr Transplantation 2010: 14:E86–E88. © 2009 John Wiley Sons & A/S. Abstract: NICCD is autosomal recessive genetic disorder, characterized cholestasis, coagulopathy, hypoglycemia, fatty liver and multiple amino acidemia. develops in the neonatal/infantile...
Only 2 patients with an oxysterol 7α-hydroxylase deficiency caused by mutations of the cytochrome P450 7B1 (CYP7B1) gene have been reported; for both, outcome was fatal. We describe clinical and laboratory features, hepatic renal histological findings, results bile acid CYP7B1 analyses a third patient. This Japanese infant presented progressive cholestatic liver disease underwent successful heterozygous living donor transplantation. Sources relevant data included medical records,...
Several transplant strategies for PH1 have been proposed, and LT is performed to correct the metabolic defects. The patients with often suffer from ESRD require simultaneous LKT, which leads a long wait due shortage of suitable organ donors. Five underwent LDLT at our institute. Three five were under dialysis before LDLT, while other two categorized as CKD stage 3. An isolated was successfully in all but first case, who had complicated postoperative courses consequently died sepsis after...
Living donor liver transplantation (LDLT) is now an established technique for treating children with end‐stage disease. Few data exist about (LT) exclusively young infants, especially infants of <3 months age. We report our single‐center experience 12 patients in which LDLT was performed during the first 3 life and compare results those older who underwent LT. All were treated at National Center Child Health Development, Tokyo, Japan. Between November 2005 to 2016, 436 Twelve these LT...
Glycogen storage disease type 1b (GSD-1b) is due to an autosomal recessive inborn error of carbohydrate metabolism caused by defects in glucose-6-phosphatase translocase. Patients with GSD-1b have severe hypoglycemia several clinical manifestations hepatomegaly, obesity, a doll-like face, and neutropenia. Liver transplantation has been indicated for glucose intolerance. This study retrospectively reviewed 4 children diagnosis who underwent living-donor liver (LDLT). Between November 2005...
Imadome K‐I, Fukuda A, Kawano F, Imai Y, Ichikawa S, Mochizuki M, Shigeta T, Kakiuchi Sakamoto Kasahara Fujiwara S. Effective control of Epstein–Barr virus infection following pediatric liver transplantation by monitoring viral DNA load and lymphocyte surface markers. Abstract: EBV‐associated PTLD is a serious complication transplantation. We performed periodical molecular EBV in 140 consecutive patients who had living‐related the National Center for Child Health Development, Tokyo....
Cytomegalovirus (CMV) infection remains the most common and critical viral that occurs after liver transplantation (LT). The current set of guidelines recommends prophylaxis over a preemptive therapy for pediatric LT; however, data regarding optimal approach LT in children are limited.We conducted universal CMV 113 (median: 16 months) live-donor at largest center Japan between November 2005 August 2009. CMV-pp65 antigenemia was monitored weekly regardless subjects' serostatus LT, ganciclovir...
Abstract Dialysis immediately before liver transplantation for patients with methylmalonic academia (MMA) the mut0 mutation is considered to be necessary reduce plasma acid levels and prevent metabolic decompensation a successful surgical outcome; however, this has not yet been conclusively confirmed. Ten pediatric underwent living donor at National Center Child Health Development, Tokyo, Japan. Seven received dialysis surgery, but three most recent did receive dialysis. We monitored MMA...
Abstract PC is produced in the liver and inhibits blood coagulation by catalyzing active factors V VIII . deficiency causes abnormal clotting that difficult to regulate anticoagulative treatments. Four reports of treated with LTx have been published; however, no report DLT as a therapy for available. We describe case 23‐month‐old girl who received compound heterozygous deficiency. Her activity was below 5%. She developed intracranial lesion frequent refractory purpura fulminans. Both her...
Kasahara M, Sakamoto S, Shigeta T, Fukuda A, Kosaki R, Nakazawa Uemoto Noda Naiki Y, Horikawa R. Living-donor liver transplantation for carbamoyl phosphate synthetase 1 deficiency.Pediatr Transplantation 2010: 14:1036–1040. © 2010 John Wiley & Sons A/S. Abstract: CPS1 is a mitochondrial matrix enzyme that catalyzes the first committed step of urea cycle, primary system removing nitrogen produced by protein metabolism using N-acetylglutamate. Patients with deficiency have severe...