A5019711108- Birth, Development, and Health
- Aquaculture disease management and microbiota
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Healthcare and Venom Research
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Animal Virus Infections Studies
- Urological Disorders and Treatments
- Lung Cancer Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Obesity, Physical Activity, Diet
- Neonatal Health and Biochemistry
- Epilepsy research and treatment
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Cystic Fibrosis Research Advances
- Invertebrate Immune Response Mechanisms
- Infectious Encephalopathies and Encephalitis
- Adrenal and Paraganglionic Tumors
- Oral and gingival health research
- Health, Environment, Cognitive Aging
Toyama Prefectural Agricultural, Forestry & Fisheries Research Center
2021-2024
National Center For Child Health and Development
2009-2024
Gunma University
2023-2024
Shujitsu University
2023-2024
Tokyo Women's Medical University
2004-2019
Délégation Paris 7
2018
Inserm
2018
Sorbonne Paris Cité
2018
Université Paris Cité
2018
Tanaka Holdings (Japan)
2018
Background Japan, which currently maintains the highest life expectancy in world and has experienced an impressive gain adult height over past century, suffered a dramatic twofold increase low birth weight (LBW) births since 1970s. Methods We observed secular trends characteristics using 64 115 249 live included vital statistics (1969–2014), as well average among 3 145 521 adults born between 1969 1996, 79 surveys conducted national, subnational or community population Japan. Results LBW...
Glycogen storage disease type 1b (GSD-1b) is due to an autosomal recessive inborn error of carbohydrate metabolism caused by defects in glucose-6-phosphatase translocase. Patients with GSD-1b have severe hypoglycemia several clinical manifestations hepatomegaly, obesity, a doll-like face, and neutropenia. Liver transplantation has been indicated for glucose intolerance. This study retrospectively reviewed 4 children diagnosis who underwent living-donor liver (LDLT). Between November 2005...
Abstract Subtelomeric imbalances are a frequent cause of cytogenetic abnormalities in patients with unexplained intellectual disability. Functional disomy Xq28 involving the methyl‐CpG‐binding protein 2 gene ( MECP2 ) has been observed mostly subtelomeric duplications. We identified three functional Xq28. A female patient showed an unbalanced translocation between 12q24.33 and Two male Xq27.1‐ Yq11.22 recombinant X‐chromosome containing duplicated material from Xq27.1 on Xp telomere,...
Summary: Purpose: We analyzed the short‐ and long‐term effects of adrenocorticotropic hormone (ACTH) therapy for patients with epileptic spasms (ESs) who did not meet criteria West syndrome (WS). Methods: The subjects were 30 patients, including 13 boys 17 girls, had received ACTH between 1970 2003. excluded WS, but included those a history WS no longer showed hypsarrhythmia at period therapy. age onset ESs ranged from 2 to 82 months median 18 months, 11 86 29 respectively. Results:...
Abstract: LDLT is an effective treatment modality in patients with congenial metabolic liver disease. PA a rare autosomal recessive disorder caused by deficiency propionyl‐CoA carboxylase. The present study demonstrates two‐yr‐old girl who was admitted for decompensation and immediately treated CHD protein intake restriction at 46 days of age. Two yr later, the patient readmitted severe complete atrioventricular block ventricular fibrillation. CHDF ECMO were indicated because progressive...
A standard growth chart is indispensable for evaluating an individual's growth. In Japan, the cross-sectional from fiscal year 2000 most commonly used in clinical setting. However, when using current to assess during puberty, two problems are encountered. First, individual pubertal height trajectory does not fit because curve of individuals rises more sharply than that indicated by chart. Second, variations timing individuals' spurt render it difficult or impossible patterns a single To...
Abstract Congenital hyperinsulinemic hypoglycemia ( CHH ) is characterized by the inappropriate secretion of insulin from pancreatic beta cells in presence hypoglycemia. We herein describe case a 5‐month‐old boy with due to congenital portosystemic shunt CPSS ). Insulin secreted flows into portal vein and first metabolized liver. First‐pass elimination liver leads great decrease concentration approximately 40–80% humans. accounts for large quantity delivery systemic circulation lack hepatic...
Abstract Context Mutations in the kisspeptin receptor (KISS1R) gene have been reported a few patients with normosmic congenital hypogonadotropic hypogonadism (nCHH) (OMIM #146110). Objectives To describe female patient nCHH and novel homozygous KISS1R mutation to assess role of pathway induce an ovulation by GnRH pulse therapy. Design, Setting, Intervention Observational study including genetic functions treatment efficiency using pump. Main Outcome Measure Response pulsatile therapy Results...
With advancing maternal age, the number of prenatal genetic tests is increasing in many countries. Prenatal tests, such as amniocentesis, chorionic villus sampling and non-invasive testing, can disclose fetal chromosomal sex, although these were originally designed to prenatally diagnose aneuploidies, trisomy 21, 18 13. Complete androgen insensitivity syndrome (CAIS) an X-linked recessive disorder caused by receptor dysfunction leading hormone resistance. The affected individuals are males...
Childhood obesity affects both pubertal growth and timing. We evaluated timing-mediated effects of childhood on growth. This retrospective, representative-population-based cohort study included 6,733 boys 6,916 girls born between April 1975 March 1976 in Akita Prefecture, Japan. Individual changes height standard deviation score 7 17 years (ΔHtSDS), body mass index Z-score at (BMIZ), estimated age peak velocity (ÂPHV) were used as surrogate indicators growth, timing, respectively....
The protective effects of a subunit vaccine, recombinant protein Edwardsiella tarda glyceraldehyde 3-phosphate dehydrogenase (Rec) combined with peptidoglycan (PGN) and polyinosinic:polycytidylic acid (polyIC), against edwardsiellosis in Japanese flounder Paralichthys olivaceus were investigated to evaluate an adjuvant property pathogen-associated molecular patterns. By injection the mixture plus polyIC (Rec + PGN Rec IC, respectively), interleukin-1β interferon (IFN)-γ mRNA levels...
Although a significant improvement in progression-free survival (PFS) has been reported the thyroid transcription factor 1 (TTF-1) positive patients under treatment for non-squamous non-small cell lung cancer (NS-NSCLC), including immune checkpoint inhibitor therapy, association between TTF-1 expression and adverse event occurrence remains unclear. Therefore, this study investigated impact of its events on PFS during pembrolizumab plus pemetrexed platinum chemotherapy NS-NSCLC. Patients who...
<title>Abstract</title> Empathy plays a crucial role in the maintenance of interpersonal relationships among mammals. Remarkably, engaging light-intensity exercise has been identified as facilitator empathic behavior, phenomenon associated with upregulation miR-486a-3p insular cortex. However, it remains to cover contribution and mechanisms changing levels that cortex exercise. We initially assessed impact (7.0 m/min, 30 min/day, five days/week for four weeks) on helping mRNA their cortex,...
Abstract Disclosure: C. Nakamura: None. M. Ishimaru: E. Tanimoto: S. Fukui: N. Ujita: H. Miyagi: Igarashi: T. Kashima: Doi: K. Yoshii: Y. Naiki: R. Horikawa: Introduction: Diabetic ketoacidosis (DKA) and hyperosmotic hyperglycemia syndrome (HHS) are severe hyperglycemic emergencies as the spectrum of insulin deficiency dehydration. HHS is known a complication with type 2 diabetes mellitus(T2DM), likely to develop in elderly patients hypertension cardiac disease triggered by infections Japan....
Abstract Disclosure: M. Ishimaru: None. S. Fukui: E. Tanimoto: C. Nakamura: N. Ujita: H. Miyagi: Doi: Igarashi: T. Kashima: K. Yoshii: Y. Naiki: R. Horikawa: [Background] Growth hormone (GH) treatment for Noonan syndrome (NS) was approved in Japan 2017. Although there have been no reports of serious adverse reactions associated with GH NS, myocardial thickening and warnings about malignant tumours which might be related to treatment. [Objective] To investigate the short- long-term safety...
Abstract Disclosure: S. Fukui: None. E. Tanimoto: N. Ujita: H. Miyagi: K. Yoshii: Yasuhiro: R. Horikawa: Background: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The utilization of molecular genetic techniques has facilitated detection CH resulting from various single-gene mutations; NKX2-1 gene-related disease stands out as one etiology symptomatic CH. We report clinical course three cases with caused by pathogenic variants. Case 1: An 8-year-old boy. He...
Abstract Disclosure: M. Igarashi: None. T. Kashima: H. Doi: K. Yoshii: Y. Naiki: R. Horikawa: [Background] Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is common after brain surgery and its’ management difficult. In Japan, tolvaptan was approved for SIADH in adults, but there are limited reports on the use children.We presented two cases which showed triphasic response neurosurgery treated with phase. We will also summarize other were phase discussion. [Case] Case1 a...
Thyroid transcription factor-1 (TTF-1) expression in patients with non-squamous non-small cell lung cancer (NS-NSCLC) is reportedly useful selecting treatment regimens and predicting life expectancy. However, only a few studies have reported the association between TTF-1 efficacy of current first-line containing immune checkpoint inhibitors. It unclear whether can be hematologic toxicity indicator receiving these regimens. Patients who received three-drug combination regimen carboplatin,...
An association between birth weight and cardiovascular disease (CVD) in adulthood has been observed many countries; however, only a few studies have conducted Asian populations.