A5001251832- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- MicroRNA in disease regulation
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- CAR-T cell therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- Hematopoietic Stem Cell Transplantation
- Advanced biosensing and bioanalysis techniques
- Vector-Borne Animal Diseases
- Ubiquitin and proteasome pathways
- Pharmacological Effects of Medicinal Plants
- Hippo pathway signaling and YAP/TAZ
- Research on Leishmaniasis Studies
- Retinoids in leukemia and cellular processes
The University of Tokyo
2022-2024
Kumamoto University
2017-2024
Japanese Foundation For Cancer Research
2013-2014
In the tumor microenvironment, senescent non-malignant cells, including cancer-associated fibroblasts (CAFs), exhibit a secretory profile under stress conditions; this senescence-associated phenotype (SASP) leads to cancer progression and chemoresistance. However, role of CAFs in metastatic lesions molecular mechanism inflammation-related SASP induction are not well understood. We show that pro-inflammatory cytokine-driven EZH2 downregulation maintains by demethylating H3K27me3 marks...
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute leukemia, the origin which considered to be precursors cells (pDCs). Since translocation (6;8)(p21;q24) a recurrent anomaly for BPDCN, we demonstrate that pDC-specific super-enhancer RUNX2 associated with MYC promoter due t(6;8). ensures expression pDC-signature genes in leukemic cells, but also confers survival and proliferative properties BPDCN cells. Furthermore, hijacked activate addition...
Purpose of review The development new antiaging medicines is great interest to the current elderly and aging population. Aging hematopoietic system attributed stem cells (HSCs), epigenetic alterations are key effectors driving HSC aging. Understanding epigenetics holds promise providing insights for combating age-related hematological malignancies. Recent findings characterized by progressive loss physiological integrity, leading impaired function increased vulnerability death. During aging,...
RUNX3, a RUNX family transcription factor, regulates normal hematopoiesis and functions as tumor suppressor in various tumors humans mice. However, emerging studies have documented increased expression of RUNX3 hematopoietic stem/progenitor cells (HSPC) subset patients with myelodysplastic syndrome (MDS) showing worse outcome, suggesting an oncogenic function for the pathogenesis hematologic malignancies. To elucidate MDS vivo, we generated RUNX3-expressing, Tet2-deficient mouse model...
Aberrant innate immune signaling in myelodysplastic syndrome (MDS) hematopoietic stem/progenitor cells (HSPCs) has been implicated as a driver of the development MDS. We herein demonstrated that prior stimulation with bacterial and viral products followed by loss Tet2 gene facilitated MDS via up-regulating target genes Elf1 transcription factor remodeling epigenome stem (HSCs) manner was dependent on Polo-like kinases (Plk) downstream Tlr3/4-Trif but did not increase genomic mutations. The...
t(8;21) is among the most common chromosomal translocations associated with human leukemia [1][2][3][4].The RUNX1-ETO (RUNX1-RUNX1T1, AML1-MTG8) fusion gene, generated by t(8;21), has been extensively investigated in field; however, its mechanistic basis remains to be fully understood.Clinical features of include: (1) association acute myeloid (AML) M2 subtype FAB classification, characterized granulocytic maturation morphology, (2) positivity for following immunophenotypic markers, HLA-DR +...
Abstract Adult T-cell leukemia/lymphoma (ATL) is caused by human leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor ( HBZ ), a leukemogenic antisense transcript of HTLV-1, abnormalities genes involved in TCR-NF-κB signaling, such as CARD11 , are detected about 90% patients. Utilizing mice expressing CD4 + T cell-specific CARD11(E626K) and/or namely -Cre mice, transgenic (Tg) and ; Tg double we clarify these genes’ pathogenetic effects. exhibit lymphocytic invasion many organs,...
Abstract High mobility group nucleosome‐binding protein 3 (HMGN3), a member of the HMGN family, modulates structure chromatin and regulates transcription through factors. HMGN3 has been implicated in development various cancers; however, underlying mechanisms remain unclear. We herein demonstrated that high expression correlated with metastasis liver fluke infection‐induced cholangiocarcinoma (CCA) patients northeastern Thailand. The knockdown CCA cells significantly impaired oncogenic...
Abstract Although epithelial ovarian cancer is an intractable and the overall five-year survival rate approximately 40 to 50%, clinically effective molecular-targeted therapeutics treat has not been available thus far. Recent progress of massively parallel sequencing technologies enabling us identify substantial number genomic aberrations including somatic mutations, indels translocations in variable types exemplified by non-small cell lung cancer. However, it still very difficult a ‘driver’...
Abstract Although epithelial ovarian cancer is an intractable and the overall five-year survival rate approximately 40 to 50%, clinically effective molecular-targeted therapeutics treat has not been available thus far. Recent progress of massively parallel sequencing technologies enabling us identify substantial number genomic aberrations including somatic mutations, indels translocations in variable types exemplified by non-small cell lung cancer. However, it still very difficult a ‘driver’...
<div>Abstract<p>RUNX3, a RUNX family transcription factor, regulates normal hematopoiesis and functions as tumor suppressor in various tumors humans mice. However, emerging studies have documented increased expression of RUNX3 hematopoietic stem/progenitor cells (HSPC) subset patients with myelodysplastic syndrome (MDS) showing worse outcome, suggesting an oncogenic function for the pathogenesis hematologic malignancies. To elucidate MDS <i>in vivo</i>, we generated...