A5100635458- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Phytochemistry and Biological Activities
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Alkaloids: synthesis and pharmacology
- Inflammasome and immune disorders
- Gastric Cancer Management and Outcomes
- Traditional and Medicinal Uses of Annonaceae
- Respiratory Support and Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Intensive Care Unit Cognitive Disorders
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Cardiac, Anesthesia and Surgical Outcomes
- Asthma and respiratory diseases
- Fungal Plant Pathogen Control
- Anesthesia and Sedative Agents
- Chromatography in Natural Products
- NF-κB Signaling Pathways
- Plant-derived Lignans Synthesis and Bioactivity
Guangzhou University of Chinese Medicine
2018-2025
Guangdong Academy of Medical Sciences
2022-2024
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2024
Capital Medical University
2014-2023
Changzhi Medical College
2021
Beijing Xuanwu Traditional Chinese Medicine Hospital
2020
Shenzhen University
2015-2017
Novel (United States)
2016
Kumamoto University
2016
Indiana University School of Medicine
2016
Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but also implicated in physiological processes like ageing. Non-resolving inflammation and prolonged neuroinflammation are unclear conditions, including In this study we studied the long-term effects endotoxemia, as systemic lipopolysaccharide (LPS) injection, focusing on role astrocyte activation cytokine release brain aged rats. A single dose LPS (2 mg/kg) or 0.9% saline was injected...
Modulation of autophagy has been increasingly regarded as a promising cancer therapeutic approach. In this study, we screened several ginsenosides extracted from Panax ginseng and identified ginsenoside Ro (Ro) novel inhibitor. blocked the autophagosome-lysosome fusion process by raising lysosomal pH attenuating cathepsin activity, resulting in accumulation autophagosome marker MAP1LC3B/LC3B SQSTM1/p62 (sequestosome 1) various esophageal cell lines. More detailed studies demonstrated that...
Traditional Chinese medicine has been used for Coronavirus disease 2019 (COVID-19) as a therapeutic option. Lianhuaqingwen capsules (LHQW) are well-recognized their efficacy, while Kegan Liyan oral liquid (KGLY), widely influenza treatment, emerged promising candidate COVID-19 therapy. This trial aims to assess whether KGLY is non-inferior LHQW in treating mild COVID-19. A total of 127 participants (63 group and 64 group) were randomly allocated receive either therapy or 1:1 ratio. The...
Acteoside, a natural phenylpropanoid glycoside from Kuding Tea, enhanced IFN-γ production in mouse lymphocytes dose-dependent manner, particularly the CD4+ and CD8+ subsets of T lymphocytes.
Neuroinflammation has been recognized as a major cause for neurocognitive diseases. Although the hippocampus considered an important region cognitive dysfunction, influence of hippocampal neuroinflammation on brain functional connectivity (FC) rarely studied. In this study, lipopolysaccharide (LPS) was used to induce systemic inflammation and in aged rat brain, while elamipretide (SS-31) treatment. Systemic were determined using ELISA, astrocyte responses during by interleukin 1 beta...
// Li 1 , Qinghai Liu Long Fan Wei Xiao Lei Zhao Yu Wang Weiguang Ye Fei Lan Bin Jia Hua Feng Changman Zhou 2 Xiuqin Yue 3 Guogang Xing 4 Tianlong Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China Anatomy & Histology, School Basic Sciences, Peking University Health Science Center, the First Affiliated Hospital Xinxiang Henan, Neurobiology, Correspondence to: Xing, email: li_limzk@163.com Wang, w_tl5595@hotmail.com Keywords: oxymatrine, arsenic...
Exploring novel anticancer agents that can trigger non-apoptotic or non-autophagic cell death is urgent for cancer treatment. In this study, we screened and identified an unexplored activity of gypenoside L (Gyp-L) isolated from Gynostemma pentaphyllum. We showed treatment with Gyp-L induces cytoplasmic vacuolation in human hepatocellular carcinoma (HCC) cells. Mechanically, initially increased the intracellular reactive oxygen species (ROS) levels, which, turn, triggered protein...
The long term impact of neuroflammation induced by systemic inflammation on astroglial transcription factor nuclear (NF)-kappaB activation in the sub-region hippocampus as well its’ association with ultra-structural changes brain cells are yet unknow. In this study, rats received 10 mg/kg lipopolysaccharide (LPS, ip injection) and NF-kappaBp65 expression astroglia neuronal and/or death microvasculature damage were assessed immunofluorescence transmission electron microscopy respectively up...
Esophageal cancer is one of the leading cause mortality in world. Due to increased drug and radiation tolerance, it urgent develop novel anticancer agent that triggers nonapoptotic cell death compensate for apoptosis resistance. In this study, we show treatment with gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, induced nonapoptotic, lysosome-associated human esophageal cells. Gyp-L-induced was associated lysosomal swelling autophagic flux inhibition. Mechanistic...
Three new quinic acid derivatives, 4-<i>O</i>-caffeoyl-3-<i>O</i>-sinapoylquinic methyl ester (<b>1</b>), 5-<i>O</i>-caffeoyl-4-<i>O</i>-syringoylquinic (<b>2</b>), and 4-<i>O</i>-caffeoyl-3-<i>O</i>-syringoylquinic (<b>3</b>), as well four coumarin glycosides, 7-<i>O</i>-(3-<i>O</i>-sinapoyl-<i>β</i>-<sc>D</sc>-glucopyranosyl)-6-methoxycoumarin (<b>12</b>), 7-<i>O</i>-(6-<i>O</i>-sinapoyl-<i>β</i>-<sc>D</sc>-glucopyranosyl)-6-methoxycoumarin (<b>13</b>),...
Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks several neurological conditions, including advance age. The contribution systemic inflammation the central nervous system (CNS) remains not fully understood. Using model peripheral endotoxemia with lipopolysaccharide (LPS) we investigated role NF-κB activity in mediating neuroinflammation dysfunction aged rats. Herein describe...
Jianpiyifei II granules (JPYF II), a herbal formula, are used for the treatment of chronic obstructive pulmonary disease (COPD) in Guangdong Provincial Hospital Chinese Medicine. The protective effects JPYF against bronchial epithelial cell apoptosis mice exposed to cigarette smoke (CS) and human lines (BEAS-2B 16-HBE) stimulated with extract (CSE) were investigated. Mice CS generated from 4 cigarettes/day 30 days administered dose (0.75, 1.5 3 g/kg/d) third week exposure. In CS,...
Summary The leaves of Ligustrum purpurascens are used in a Chinese traditional tea called small‐leaved kudingcha, which is rich phenylpropanoid glycosides ( PPG s) and has many beneficial properties. Two critical exoacting glycoside hydrolase enzymes (glucosidases) involved carbohydrate digestion α‐glucosidase α‐amylase. We investigated the properties s from L. for inhibiting α‐amylase activity vitro found IC 50 values 1.02 0.73 mg mL −1 , respectively. patterns both were mixed‐inhibition...
Based on electroencephalogram (EEG) analysis, index of consciousness (IoC) monitoring is a new technique for anesthesia depth. IoC divided into IoC1 (depth sedation) and IoC2 analgesia). The potential concurrent to expedite postoperative convalescence remains be elucidated. We investigated whether combined can effectively enhances recovery compared with bispectral (BIS) in elderly patients undergoing laparoscopic urological surgery under general anesthesia.In this prospective, controlled,...
Jianpiyifei II granule (JPYF II) is an oriental herbal formula used clinically in China to treat chronic obstructive pulmonary disease (COPD). The aim of the present study was investigate anti-inflammatory and antioxidative activities JPYF a mouse model COPD induced by lipopolysaccharide (LPS) cigarette smoke (CS) RAW264.7 cells stimulated with extract (CSE). Mice were given LPS via intratracheal instillation on days 1 15 exposed CS generated from 4 cigarettes/day for 28 days. mice treated...
Aims: The occurrence of vascular permeability pulmonary edema in acute lung injury (ALI) is related to the imbalance alveolar fluid transport. Regulating active transport by aquaporins (AQPs), epithelial sodium channels (ENaCs), and Na+-K+-ATPase can effectively reduce cavity protect against ALI. We evaluated therapeutic effects total flavonoids, extracted from Nervilia fordii (TFENF), investigated its potential mechanisms a rat ALI model. Materials methods: A model lipopolysaccharide (LPS,...