A5062669228- Chronic Kidney Disease and Diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- IL-33, ST2, and ILC Pathways
- Parathyroid Disorders and Treatments
- Educational Technology and Pedagogy
- Innovative Educational Techniques
- Hormonal Regulation and Hypertension
- Heme Oxygenase-1 and Carbon Monoxide
- Extracellular vesicles in disease
- Bariatric Surgery and Outcomes
- Adrenal and Paraganglionic Tumors
- Diabetes and associated disorders
- Dialysis and Renal Disease Management
- Safety and Risk Management
- Cancer, Lipids, and Metabolism
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Birth, Development, and Health
- Evaluation and Optimization Models
Sun Yat-sen Memorial Hospital
2014-2024
Sun Yat-sen University
2014-2024
Diabetic foot ulcer is a life-threatening clinical problem in diabetic patients. Endothelial cell-derived small extracellular vesicles (sEVs) are important mediators of intercellular communication the pathogenesis several diseases. However, exact mechanisms wound healing mediated by endothelial sEVs remain unclear. were isolated from human umbilical vein cells (HUVECs) pretreated with or without advanced glycation end products (AGEs). The roles HUVEC-derived on biological characteristics...
Rational measures in estimating adiposity distribution diabetic patients has yet to be validated. This study aims provide insight about the possible links between routinely available body parameters and development of both diabetes insulin resistance.We performed a population-based cross-sectional 9496 subjects aged 40 years or older. All including mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height (WHtR), visceral (VAI), (BAI) lipid accumulation product (LAP)...
Epidemiological evidence suggests that lipid parameters are related to the progression of chronic kidney disease (CKD). Nevertheless, prospective studies comprehensively assess effect routinely available measures on development CKD lacking. The aim this study was longitudinally influence metabolism indicators presence in a large community-based population. We conducted cohort at Sun Yat-sen Memorial Hospital, China, with 5345 patients 40 years or older. Cox regression models were conducted,...
Chronic kidney disease (CKD) has become a major global health issue, and abnormalities of glucose metabolism are risk factor responsible for development CKD. We aimed to investigate associations between indices CKD in Chinese population determine which index is superior predicting incident performed community-based on 5232 subjects aged ≥40 years without baseline was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 or urinary albumin-to-creatinine ratio (UACR)...
Background and aims: Epidemiological studies have shown that increasing parity is associated with risk of hypertension diabetes in parous women.However, the relationship between degree chronic kidney disease (CKD) still unknown.Results: Parous women higher had increased age, body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, insulin decreased high-density lipoprotein cholesterol, eGFR education levels.Compared one-child birth, those more than two-child...
Purpose: Patients with primary aldosteronism (PA) have an increased risk of target-organ damage (TOD), but whether metabolic syndrome (MetS) is more prevalent and contributes to TOD in PA patients remains unresolved. We aimed evaluate the associations between MetS profiles Chinese individuals. Methods: Metabolic parameters preclinical including left ventricular hypertrophy, estimated glomerular filtration, microalbuminuria; insulin sensitivity or resistance, islet β-cell function assessed by...
Abstract Background Women with a higher number of pregnancies have risk developing cardiovascular diseases. Subtle fluctuations in albumin excretion could be related to pathophysiologic changes the vascular system. We aimed investigate possible association parity low-grade albuminuria. Methods conducted community-based study 6495 women aged 40 years or older. Low-grade albuminuria was defined according highest quartile urine albumin-to-creatinine ratio participants free micro-...
Individuals with metabolic syndrome have elevated risks of micro- and macro-albuminuria as well chronic kidney disease (CKD).To assess the influence abnormalities on presence low-grade albuminuria (below threshold for microalbuminuria). Design, participants, main outcome measures: This community-based cohort study included 3,935 eligible individuals aged 40 years or older. The was detected in those without analyzed according to highest quartile baseline urinary albumin-to-creatinine ratio...
This study aimed to perform exhaustive bioinformatic analysis by using GSE29221 micro-array maps obtained from healthy controls and Type 2 Diabetes (T2DM) patients. Raw data are downloaded the Gene Expression Omnibus database processed limma package in R software identify Differentially Expressed Genes (DEGs). ontology functional Kyoto Encyclopedia Genome Pathway performed determine biological functions pathways of DEGs. A protein interaction network is constructed STRING Cytoscape key...
Background Chronic kidney disease (CKD) has become a major global health issue, and abnormalities of glucose metabolism are risk factor responsible for development CKD. We aimed to investigate associations between indices CKD in Chinese population, determine which index is superior predicting incident Methods This community-based population study included 5232 subjects aged ≥40 years without baseline was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or urinary...
In order to ensure the quality of nursing students' clinical teaching,a ward teaching evaluation index system is established based on literature retrieval and experience.Delphi method used make three rounds enquiry 23 experts,and listen expert opinion suggestion.The positive coefficient consultation were＞95％,variation primary secondary indicators ＜ 0.2000 mean importance assignment all ＞ 4.00,having statistical significance.Finally,the contains 4 first-level indexes 20 evaluation. Key...