A5031403292- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Vitamin D Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Case Reports on Hematomas
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Vitamin C and Antioxidants Research
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Machine Learning in Healthcare
- Endoplasmic Reticulum Stress and Disease
- Birth, Development, and Health
- Lipid metabolism and disorders
- Burkholderia infections and melioidosis
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Gout, Hyperuricemia, Uric Acid
Hainan Medical University
2018-2025
Hainan General Hospital
2020-2025
Second Xiangya Hospital of Central South University
2020-2021
Central South University
2020-2021
Haikou City People's Hospital
2014
Abstract Objective To assess the prevalence of diabetes and its risk factors. Design Population based, cross sectional study. Setting 31 provinces in mainland China with nationally representative data from 2015 to 2017. Participants 75 880 participants aged 18 older—a sample Chinese population. Main outcome measures Prevalence among adults living China, by sex, regions, ethnic groups, estimated 2018 American Diabetes Association (ADA) World Health Organization diagnostic criteria....
Background: Mandatory universal salt iodization (USI) has been implemented in China for 20 years. Although iodine deficiency disorders are effectively controlled, the risk of excess have debated. Methods: A nationally representative cross-sectional study with 78,470 enrolled participants, aged 18 years or older, from all 31 provincial regions mainland was performed. The participants were given a questionnaire and underwent B-mode ultrasonography thyroid. Serum concentrations thyroid...
Background: Iodine is important in both thyroid function and human metabolism. Studies have explored the effect of iodine on metabolic disorders through function. This study aimed to investigate relationship between status disorders, such as syndrome (MetS), hypertension, impaired glucose metabolism, central obesity, dyslipidemia. Methods: A total 51,795 subjects aged ≥18 years from TIDE (Thyroid Disorders, Status Diabetes, a national epidemiological cross-sectional study) program were...
Background Universal salt iodization (USI) was implemented in mainland China 1996. The prevalence of hyperthyroidism and its risk factors now require examination. Methods Data were acquired from a nationwide Thyroid, Iodine, Diabetes Epidemiological survey (TIDE 2015–2017) 78,470 subjects 31 provinces. Iodine status, thyroid hormones antibodies measured. Results After two decades USI, the overt (OH), Graves’ disease (GD), severe subclinical (severe SCH), mild (mild SCH) 0.78%, 0.53%, 0.22%,...
Background: Iodine intake is associated with thyroid autoimmunity. In this study, we evaluated the changes in autoimmunity after 20 years of universal salt iodization (USI) China. Methods: A total 78,470 subjects (18 or older) from 31 provincial regions mainland China participated study. Serum peroxidase antibody (TPOAb), thyroglobulin (TgAb), TSH receptor antibody, thyrotropin (TSH), and urinary iodine concentration (UIC) were measured. Results: Positive TPOAb TgAb detected 10.19% [CI...
Formal risk assessment is crucial for diabetes prevention. We aimed to establish a practical nomogram predicting the incidence of prediabetes and conversion diabetes.A cohort 1428 subjects was collected develop prediction models. The LASSO used screen important factors in compared with other algorithms (LR, RF, SVM, LDA, NB, Treebag). Multivariate logistic regression analysis construct model diabetes, drawn predictive nomogram. performance nomograms evaluated by receiver-operating...
Purpose: The expression of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) are very common in the sera patients with autoimmune diseases (AITD). relationship between auto-antibodies occurrence glucose lipid metabolic disorders remains unclear. This study was performed to investigate correlation presence serum TPOAb/TgAb those euthyroid general population. Methods: data this derived from Thyroid Disease, Iodine status Diabetes National epidemiological (TIDE) survey, a...
Background: Subclinical hypothyroidism is diagnosed based on serum thyrotropin (TSH) reference intervals, which in turn are affected by many factors. Methods: Data were acquired from a Chinese nationally representative cross-sectional study of 78,470 participants (TIDE study). The total population the TIDE program, and was subset defined National Academy Clinical Biochemistry (NACB) guidelines. Serum concentrations thyroid hormones, TSH, antibodies, urine iodine concentration (UIC) measured....
Background: Despite the implementation of universal salt iodization (USI) program for correction iodine deficiency in China ∼20 years, actual nutrition status Chinese residents and prevalence excess are issues that need to be addressed. This nationally representative cross-sectional study was conducted across all 31 provinces mainland gather extensive data on influential factors. Methods: included 78,470 participants, aged 18 years or older, who were interviewed asked answer a questionnaire....
Abstract Men and women are sexually dimorphic but whether common anthropometric biochemical parameters predict type 2 diabetes (T2D) in different ways has not been well studied. Here we recruit 1579 participants Hainan Province, China, group them by sex. We compared the prediction power of T2D two sexes association, regression, Receiver Operating Characteristic (ROC) analysis. HbA1c is associated with FPG stronger than men regression coefficient higher, consistent higher for T2D. Age, waist...
Diabetes mellitus (DM) is a chronic disease that seriously threatens human health. Prediabetes stage in the progression of DM. The level clinical indicators including fasting plasma glucose (FPG), 2-h postprandial (2hPG), and glycosylated hemoglobin (HbA1C) are diagnostic markers diabetes. In this genome-wide association study (GWAS), we aimed to investigate genetic variants with these phenotypes Hainan prediabetes. study, recruited 451 prediabetes patients from residents aged ≥18 years who...
Maturity-onset diabetes mellitus of the young (MODY) is a monogenic characterized by autosomal dominant inheritance. Its atypical clinical features make diagnosis difficult and it can be misdiagnosed as type 1 or 2 diabetes. Fourteen subtypes MODY have been diagnosed so far, which MODY12 caused mutation ABCC8 (ATP Binding Cassette Subfamily C Member 8) gene, rarely reported in China. This paper reports Chinese family rare missense on has not to associated with China other countries, aim...
Background: Malnutrition in early life may permanently change the structure and function of body, which lead to a number diseases adulthood. The effect famine exposure during on thyroid disorders remains unclear. This study investigated association between Great Chinese Famine (1959-1961) Methods: Nine thousand eight hundred eighty-one subjects with appropriate birth dates derived from Thyroid disorders, Iodine status, Diabetes Epidemiological survey were included. defined by test results...
Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of study was to analyze association between SCH newly-diagnosed hypertension.Methods: Based on data from Thyroid disease, Iodine nutrition Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals 7,719 patients aged ≥18 years were enrolled. Patients a history hypertension or disease excluded. determined by manufacturer...
Gestational diabetes mellitus (GDM) is considered an imbalance of glucose metabolism and insulin resistance during pregnancy.To evaluate the levels periostin (POSTN) in patients with GDM investigate association between POSTN GDM.A total 30 pregnant women (NC group) (GDM were involved. The mouse model was established by intraperitoneally injecting streptozotocin. oral tolerance test (OGTT), insulin, indices tested. An immunohistochemical Western blot assay conducted to determine expression...
The aim of the present study was to explore effects various combinations exenatide, metformin (MET) and biphasic insulin aspart 30 (BIA30) on type 2 diabetes mellitus (T2DM). Two hundred overweight or obese patients newly diagnosed with T2DM were evenly randomized into two groups: A (twice daily for all: Phase I, 5 µg exenatide + 0.5 g MET 4 weeks, then 10 8 weeks; II, 12 III, 0.3-0.4 U/kg/day BIA30 weeks) B (Phases III matched phases II I in group A). In groups a significant decrease...
Abstract Lack of efficient insulin secretion from the pancreas can lead to impaired glucose tolerance (IGT), prediabetes, and diabetes. We have previously identified two IGT-associated single nucleotide polymorphisms (SNPs) rs62212118 rs13052524 located at overlapping genes: MRPS6 SLC5A3. In this study, we show that but not SLC5A3 regulates glucose-stimulated (GSIS) in primary human β-cell a mouse pancreatic insulinoma line. Data mining biochemical studies reveal is positively regulated by...
Background: Vitamin D deficiency is considered to be a global health problem. The purpose of this study was evaluate the prevalence vitamin and analyze its related factors among adult residents in Hainan, tropical island province southern China.
Premature ovarian failure is characterized by amenorrhea, hypoestrogenism, and hypergonadotropinism, occurs in women under 40 years of age. The prevalence premature younger than 20 age only 0.01%. Immune disorders are one the causes failure. Graves' disease chronic urticaria also associated with immune disorders.We report a case 15-year-old Han Chinese girl complicated urticaria. She experienced menarche at 13 presented amenorrhea after 7 months irregular menstruation. Laboratory...
The aim of this study was to analyze the clinical characteristics diabetes mellitus patients with Burkholderia pseudomallei septicemia and evaluate strategies diagnosis treatment. characteristics, diagnosis, treatment, prognosis 39 B. were retrospectively analyzed. Farmers, fishermen workers found be high-risk groups. manifestations diverse without specific features, but mainly presented acute fulminant septicemia, diabetic ketoacidosis, abscesses in tissues or/and organs. Patients showed...
Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 a cohort 1579 East Asian individuals Hainan Province China, we find that the associations proinsulin, P/I diabetic indicators distinct, sometimes opposite regression patterns normal, prediabetic subgroups. The strength...