A5031853937- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- Molecular Sensors and Ion Detection
- Lung Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Mechanisms of cancer metastasis
- Radiomics and Machine Learning in Medical Imaging
- Analytical Chemistry and Sensors
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Lung Cancer Research Studies
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- Nanowire Synthesis and Applications
- Electrochemical sensors and biosensors
- Medical Imaging and Pathology Studies
- Congenital Anomalies and Fetal Surgery
- PI3K/AKT/mTOR signaling in cancer
- Advanced biosensing and bioanalysis techniques
Taichung Veterans General Hospital
2016-2025
National Health Research Institutes
2010-2023
National Chung Cheng University
2022
National Yang Ming Chiao Tung University
2014-2019
National Yang Ming University Hospital
2014-2019
Taiwan Shoufu University
2010-2019
Memorial Sloan Kettering Cancer Center
2014-2017
Shinshu University
2016
Institute of Clinical Research
2014-2015
Cornell University
2015
To examine the significance of proposed International Association for Study Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) histologic subtypes lung adenocarcinoma patterns recurrence and, among patients who recur following resection stage I adenocarcinoma, postrecurrence survival (PRS).We reviewed with had undergone complete surgical from 1999 to 2009 (N = 1,120). Tumors were subtyped by using IASLC/ATS/ERS classification. The effects dominant...
Purpose To perform competing risks analysis and determine short- long-term cancer- noncancer-specific mortality morbidity in patients who had undergone resection for stage I non-small-cell lung cancer (NSCLC). Patients Methods Of 5,371 consecutive curative-intent of primary at our institution (2000 to 2011), 2,186 with pathologic NSCLC were included the analysis. All preoperative clinical variables known affect outcomes analysis, specifically, Charlson comorbidity index, predicted...
Nrf2 is a key transcription factor for genes coding antioxidants, detoxification enzymes, and multiple drug resistance it also confers to anticancer drugs. Here, we hypothesized that mutant p53 could upregulate expression at the transcriptional level, thereby conferring cisplatin in non-small cell lung cancer (NSCLC). Luciferase reporter assays real-time PCR analysis indicated promoter activity its mRNA levels were markedly suppressed by wild-type p53, but not p53. Chromatin...
Inhibitors of antiapoptosis protein (IAP) have been implicated in the resistance to cisplatin. Therefore, verifying which pathway is involved cIAP2 upregulation may be helpful finding a feasible inhibitor increase chemotherapeutic efficacy human papillomavirus (HPV)-infected lung cancer.Specific inhibitors different pathways were used verify transcription. promoter fragments with various deletions and/or mutations constructed by site-directed mutagenesis. cIAP2, epidermal growth factor...
Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, role GLK recurrence remains unclear. Here, we report that transgenic promotes tumor metastasis cell migration through scaffold protein IQ motif-containing GTPase-activating 1(IQGAP1). mice displayed enhanced distant metastasis. IQGAP1 was identified as a GLK-interacting protein; two proline-rich regions WW domain mediated this interaction. colocalized at...
Abstract Purpose: Fas ligand (FasL) −844T/C polymorphism (rs763110) has a demonstrated association with lung cancer risk. FasL −844CC higher expression been suggested to contribute tumor progression via immune escape. However, the impact of on clinical outcome non–small cell (NSCLC) remains be identified. Experimental Design: A total 385 adjacent normal tissues from patients NSCLC were collected determine by PCR-based restriction fragment length polymorphism. mRNA and protein in tumors...
Pulmonary sequestration (PS) is a rare congenital lung malformation. In this study, we evaluated the diagnosis and treatment of PS in 31 adult patients at single institution.A retrospective review all 16 years age older with institution between January 1985 2011 was conducted. The following data were analyzed for patients: major symptoms, diagnostic procedures, operative findings, techniques, postoperative complications, outcome.Our study involved patients, 17 male 14 female, an average 32.1...
// Chung-Ping Hsu 1, 2 , Huai-Chia Chuang 3 Ming-Ching Lee 4 Hsiao-Hui Tsou 5 Li-Wen 1 Ju-Pi Li Tse-Hua Tan 3, 6 Division of Thoracic Surgery, Department Taichung Veterans General Hospital, Taichung, 40705, Taiwan Faculty Medicine, School National Yang-Ming University, Taipei, 11221, Immunology Research Center, Health Institutes, Zhunan, 35053, Institute Clinical Biostatistics and Bioinformatics, Population Sciences, Pathology & Immunology, Baylor College Houston, Texas, 77030, USA...
Micropapillary (MIP) histologic subtype included in the classification of lung adenocarcinomas (ADCs) is associated with both size- and stage-independent poor prognoses. MIP pattern ADCs, even at small, early stages, correlates high lymphovascular invasion, visceral pleural invasion lymph node metastases. Recently, we reported that patients a component are higher risk locoregional recurrence after limited resection. Identification only possible permanent pathologic sections; preoperative...