A5071781325- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Galectins and Cancer Biology
- Bone and Joint Diseases
- Long-Term Effects of COVID-19
- Lung Cancer Research Studies
- Protein Tyrosine Phosphatases
- Inflammatory Myopathies and Dermatomyositis
- Neonatal Respiratory Health Research
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- HIV-related health complications and treatments
- Respiratory Support and Mechanisms
- DNA Repair Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- Selenium in Biological Systems
- Fibroblast Growth Factor Research
- Acupuncture Treatment Research Studies
- Melanoma and MAPK Pathways
Chung Shan Medical University Hospital
2020-2025
Chung Shan Medical University
2020-2024
China Medical University
2016-2022
China Medical University Hospital
2016-2022
National Health Research Institutes
2009-2016
National Tsing Hua University
2005-2007
Monocytes/macrophages are important in orchestrating inflammatory responses. However, knowledge of the long noncoding RNA (lncRNA) regulation monocytic cell differentiation and diseases remains limited. We aimed to elucidate role 17 kb lncRNA transcript T cells (NTT) monocyte functions. Knockdown chromatin immunoprecipitation (ChIP) assays THP-1 (human leukemia line) revealed that NTT is regulated by key transcription factor C/EBPβ it binds promoter nearby gene PBOV1 via hnRNP-U....
T cell activation is dependent upon phosphorylation of MAPKs, which play a critical role in the regulation immune responses. Dual-specificity phosphatase 14 (DUSP14; also known as MKP6) classified MAPK phosphatase. The vivo functions DUSP14 remain unclear. Thus, we generated DUSP14-deficient mice and characterized roles deficiency cells resulted enhanced proliferation increased cytokine production activation. directly interacted with TGF-β-activated kinase 1 (TAK1)-binding protein (TAB1)...
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that characterized by systemic inflammation and multiple organ failures. Dysregulation of T cells plays critical role in SLE pathogenesis. Our previous study indicates JKAP (also named DUSP22) inhibits T-cell activation knockout mice develop spontaneous autoimmunity; therefore, we investigated whether downregulation involved patients. protein levels purified were examined immunoblotting using blood samples from 43 patients 32...
The early development of the gut microbiome is governed by multiple factors and has significantly long-term effects on later-in-life health. To minimize inter-individual variations in environment, we determined developmental trajectories 28 healthy neonates during their stay at a postpartum center. Stool samples were collected three time points: first-pass meconium within 24 h life, 7 days age. Illumina sequencing V3-V4 region 16S rRNA was used to investigate microbiota profiles. We found...
This comprehensive review delves into the multifaceted roles of mesenchymal stem cells (MSCs) in leukemia, focusing on their interactions within bone marrow microenvironment and impact leukemia pathogenesis, progression, treatment resistance. MSCs, characterized by ability to differentiate various cell types modulate immune system, are integral BM niche, influencing hematopoietic maintenance functionality. extensively explores intricate relationship between MSCs leukemic acute myeloid...
JNK pathway-associated phosphatase (JKAP, also named DUSP22) is expressed in various tissues, indicating that JKAP may have an important biological function. We showed localized the actin filament-enriched region. Expression of reduced cell migration, whereas a mutant lacking catalytic activity promoted motility. efficiently removed tyrosine phosphorylation several proteins. identified focal adhesion kinase (FAK) as substrate JKAP. Overexpression JKAP, but not activity, decreased FAK at...
Immune-mediated hematopoietic destruction is a key factor in idiopathic severe aplastic anemia (SAA). With great immunomodulatory functions, mesenchymal stem cells (MSCs) are important for bone marrow niche. While the underlying etiology of immunologic changes SAA remains unknown, dysfunctional MSCs implicated as major cause. To provide evidence their defects immunomodulation, alterations regulating T cell differentiation were determined. During from CD4+ into helper 17 (Th17) under...
Oxidative stress attacks cells, causing the accumulation of reactive oxygen species, leading to aging and age-related diseases. The trace mineral selenium (Se) has ability protect against oxidative stress. mushroom, Tropicoporus linteus (TL), health-promoting properties; however, its combat is still under investigation. In this study, we aimed study whether TL Se-enriched (Se-TL) possess antioxidant properties. We observed that Se content in Se-TL mycelium was higher than mycelium. Both...
// Chung-Ping Hsu 1, 2 , Huai-Chia Chuang 3 Ming-Ching Lee 4 Hsiao-Hui Tsou 5 Li-Wen 1 Ju-Pi Li Tse-Hua Tan 3, 6 Division of Thoracic Surgery, Department Taichung Veterans General Hospital, Taichung, 40705, Taiwan Faculty Medicine, School National Yang-Ming University, Taipei, 11221, Immunology Research Center, Health Institutes, Zhunan, 35053, Institute Clinical Biostatistics and Bioinformatics, Population Sciences, Pathology & Immunology, Baylor College Houston, Texas, 77030, USA...
L5, the most negatively charged subfraction of low-density lipoprotein (LDL), is implicated in atherogenesis. We examined relationship between plasma L5 levels and occurrence subclinical atherosclerosis patients with rheumatoid arthritis (RA). Using anion-exchange purification fast-protein liquid chromatography, we determined proportion LDL (L5%) 64 RA 12 healthy controls (HC). Plasma L5% were significantly higher (median, 1.4% 1.92 mg/dL) compared HC (0.9%, p < 0.005; 1.27 mg/dL, 0.05)...
Excess inflammatory processes play a key detrimental role in the pathophysiology of acute lung injury (ALI). Mesenchymal stem cells (MSCs) were reported to be beneficial ALI, but underlying mechanisms have not been completely understood. The present study aimed examine involvement MyD88−NFκB signaling immunomodulation MSCs mice with lipopolysaccharides (LPS)-induced ALI. We found that serum concentrations IL-6, TNF-α, MCP-1, IL-1β, and IL-8 significantly decreased at 6 h after LPS-induced...
Aberrant composition of glycans in the tumor microenvironment (TME) and abnormal expression extracellular matrix proteins are hallmarks hepatocellular carcinoma (HCC); however, mechanisms responsible for establishing TME remain unclear. We demonstrate that chondroitin polymerizing factor (CHPF), an enzyme mediates elongation sulfate (CS), is a critical elicitor malignant characteristics HCC as it modifies potent suppressor, decorin (DCN). CHPF frequently downregulated tumors, which...
Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine. It contains many nutrients for human health. A fungal immunomodulatory protein (FIP) has been isolated from V. volvacea and named FIP-vvo. Although the regulatory effects of FIPs on immunity have identified, impact FIP-vvo modulating dendritic cells (DCs), which play key role to connect innate adaptive immunity, not known. In this study, we aim study effect DC maturation function. We found...
Nasopharyngeal carcinoma (NPC) is the most common cancer that occurs in nasopharynx, and it difficult to detect early. The main cause of death NPC patients metastasis. Lipocalin 2 (LCN2) has been shown be involved a variety carcinogenesis processes. Here, we aimed study role LCN2 cells determine its underlying mechanism. We found was expressed differently cell lines, namely HONE-1, NPC-39, NPC-BM. down-regulation levels by siRNA targeting (siLCN2) increased migration invasion HONE-1 cells,...
KCNQ1 encodes a potassium voltage-gated channel and represents susceptibility locus for type 2 diabetes mellitus (T2DM). Here, we explored the association between polymorphisms hypertension risk in individuals with T2DM, as well role of vascular smooth muscle cell contraction vitro. To investigate relationship developing patients divided T2DM cohort into (n = 452) non-hypertension 541) groups. The Mann-Whitney U test, chi-square multivariate regression analyses were used to assess clinical...
Abstract Timely induction of cyclin B1 controls mitotic entry, whereas its proteolysis is essential for exit. By contrast, transcription repressed during G 2 arrest induced by DNA damage. The p38 mitogen‐activated protein kinase involved in the checkpoint; yet, impact on levels remains unclear. Here we show that untimely following activation contributes to checkpoint. Exposing early cells arsenite impeded accumulation, Cdk1 activation, and ‐to‐M progression. Conversely, was non‐degradable...
Abstract Background Liver cirrhosis is one of the main causes morbidity and mortality in liver diseases. Chinese herbal medicine (CHM) has long been used for clinical treatment This study was designed to explore usage frequency prescription patterns CHM patients with decompensated evaluate long-term effects on overall mortality. Methods Two thousand four hundred sixty-seven (ICD-9-CM code: 571.2, 571.5, 571.6) diagnosed between 2000 2009 Taiwan were identified from registry catastrophic...
QuantiFERON-TB-Gold (QFT-G) conversion is frequently observed in rheumatoid arthritis (RA) patients receiving biologic therapy. However, there have not been any known biomarkers available for detecting tuberculosis (TB) QFT-G converters. We aimed to evaluate clinical utility of cytokines/chemokines TB with conversion. Among a total 227 RA who underwent assay, 187 QFT-G-negative received therapy without isoniazid prophylaxis. assay was repeated at week 52 or the time diagnosis. Levels were...
Abstract Aim Dysregulated apoptosis has been implicated in autoimmune diseases. In the present study, we investigated apoptosis‐related cytokines and patients with primary antiphospholipid syndrome (pAPS). Method We prospectively recruited 12 pAPS patients, 17 antibody (APA)‐positive systemic lupus erythematosus (SLE) without APS manifestations (APA + SLE), 13 SLE secondary (APS SLE) 10 healthy controls (HCs). Plasma levels of soluble apoptosis‐inducing ligands cytokines, expression...
Fibroblast growth factor receptor 4 (FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression many cancers. However, its association, such as expression levels, lung cancer controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 rs1966265 A/G) risk adenocarcinoma epidermal (EGFR) mutation status...