A5018244075- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Cutaneous lymphoproliferative disorders research
- Radiomics and Machine Learning in Medical Imaging
- Systemic Lupus Erythematosus Research
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Virus-based gene therapy research
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Hair Growth and Disorders
- Inflammatory Biomarkers in Disease Prognosis
- Asthma and respiratory diseases
Yale University
2016-2025
Oxford University Press (United Kingdom)
2020
Washington University in St. Louis
2008-2014
The University of Melbourne
2012
Amgen (United States)
2012
Peter MacCallum Cancer Centre
2012
James A. Haley Veterans' Hospital
1999-2001
University of South Florida
1999-2001
Accumulated data from animal models and human cancer patients strongly support the concept that immune system can identify control nascent tumor cells in a process called immunosurveillance. In addition, also promote progression through chronic inflammation, immunoselection of poorly immunogenic variants, suppressing antitumor immunity. Together, dual host‐protective tumor‐promoting actions immunity are referred to as immunoediting. The current framework immunoediting is dynamic comprised...
Here we report the effects of loss Toll-like receptor-associated signaling adaptor myeloid-differentiation factor 88 (MyD88) on tumor induction in two distinct mouse models carcinogenesis. The 7,12-dimethylbenz[ a ]anthracene (DMBA)/12- O -tetradecanoylphorbol 13-acetate (TPA)-induced skin papilloma model depends proinflammatory processes, whereas 3′-methylcholanthrene (MCA) fibrosarcoma has been used by immunologists to illustrate innate and adaptive immune surveillance cancer. When exposed...
Abstract Specific mechanisms by which tumor-infiltrating lymphocytes (TIL) become dysfunctional remain poorly understood. Here, we employed a two-pronged approach using single-cell mass cytometry and tissue imaging technologies to dissect TILs from 25 patients with resectable 35 advanced non–small cell lung cancer (NSCLC). We identified burned-out CD8+ TIL subset (Ebo) that specifically accumulated within the tumor microenvironment (TME) but not in adjacent nontumoral tissues. Ebo showed...
Systemic lupus erythematosus (SLE) and discoid (DLE) of the skin are autoimmune diseases characterized by inappropriate immune responses against self-proteins; key elements that determine disease pathogenesis progression largely unknown. Here, we show mice lacking inhibitory receptor VISTA or programmed death-1 homolog (PD-1H KO) on a BALB/c background spontaneously develop cutaneous systemic resembling human lupus. Cutaneous lesions PD-1H KO have clustering plasmacytoid dendritic cells...
Abstract Basic science breakthroughs in T-cell biology and immune–tumor cell interactions ushered a new era of cancer immunotherapy. Twenty years ago, immunoediting was proposed as framework to understand the dynamic process by which immune system can both control shape its most complex form occurs through three phases termed elimination, equilibrium, escape. During progression these phases, tumors undergo immunoediting, rendering them less immunogenic more capable establishing an...
Abstract Cancer immunoediting, the process by which immune system controls tumor growth and shapes immunogenicity, consists of 3 stages: elimination, equilibrium, escape. The molecular mechanisms that underlie equilibrium phase, during maintains dormancy, remain incompletely defined. Here, we investigated length phase control methycholanthrene (MCA)-induced or p53 mutant cancers showed critical opposing roles interleukin (IL)-23 IL-12 in maintaining cancer cells a state immune-mediated...
Abstract Background Malignant meningiomas are fatal and lack effective therapy. As M2 macrophages the most prevalent immune cell type in human meningiomas, we hypothesized that normalizing this immunosuppressive population would be an treatment strategy. Methods We used CIBERSORTx to examine proportions of 22 subsets meningiomas. targeted colony-stimulating factor 1 (CSF1) or CSF1 receptor (CSF1R) axis, important regulator macrophage phenotype, using monoclonal antibodies (mAbs) a novel...
T cells are often absent from human cancer tissues during both spontaneously induced immunity and therapeutic immunotherapy, even in the presence of a functional cell-recruiting chemokine system, suggesting existence cell exclusion mechanisms that impair infiltration. Using genome-wide vitro screening platform, we identified role for phospholipase A2 group 10 (PLA2G10) protein exclusion. PLA2G10 up-regulation is widespread cancers associated with poor infiltration tumor tissues....
Cutaneous squamous cell carcinoma (cSCC) incidence and deaths continue to rise, underscoring the need for improved cSCC prevention. Elimination of actinic keratosis (AK) precursor lesions is a major strategy prevent cSCC. Topical calcipotriol 5-fluorouracil (5-FU) have been shown eliminate AKs reduce risk development, but mechanism was undefined. In this issue JCI, Oka et al. demonstrate that type 2 immunity necessary sufficient elimination premalignant keratinocytes Paired biopsies from AK...
Cutaneous Lupus is an inflammatory skin disease causing highly morbid inflamed and hair loss. In order to investigate the pathophysiology of cutaneous lupus, we performed single-cell RNA spatial sequencing lesional non-lesional lupus compared healthy controls. Pathway enrichment analyses keratinocytes revealed elevated responses type I interferon, II tumor necrosis factor, apoptotic signaling. Detailed clustering demonstrated unique fibroblasts specific with likely roles in cell recruitment...
Cutaneous lupus erythematosus (CLE) is a disfiguring autoimmune skin disease characterized by an inflammatory infiltrate rich in T cells, which are strongly implicated tissue damage. How these cells adapt to the environment and promote inflammation damage not known. In nephritis, we have previously identified gene program kidney-infiltrating that dependent on hypoxia-inducible factor-1 (HIF-1), transcription factor critical for cellular developmental response hypoxia as well...
Detection of individual cytokines in routine biopsies from patients with inflammatory skin diseases has the potential to personalize diagnosis and treatment selection, but this approach been limited by technical feasibility. We evaluate whether a chromogen-based RNA situ hybridization can be used detect druggable psoriasis atopic dermatitis. A series (n = 20) dermatitis 26) were stained using for IL4, IL12B (IL-12/23 p40), IL13, IL17A, IL17F, IL22, IL23A (IL-23 p19), IL31, TNF (TNF-α). NOS2...