A5034294182- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Genetic and rare skin diseases.
- Dermatological and Skeletal Disorders
- Nail Diseases and Treatments
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders
- Skin Diseases and Diabetes
- Tumors and Oncological Cases
- melanin and skin pigmentation
- Oral Health Pathology and Treatment
- Polyomavirus and related diseases
- Medicine and Dermatology Studies History
- Cancer Diagnosis and Treatment
- Inflammatory Myopathies and Dermatomyositis
- CAR-T cell therapy research
- Vascular Malformations and Hemangiomas
- Dermatological diseases and infestations
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Melanoma and MAPK Pathways
Yale University
2016-2025
Yale New Haven Hospital
2006-2025
Twitter (United States)
2025
Christ University
2024
Medical University of South Carolina
2022-2023
UConn Health
2022-2023
American Academy of Dermatology
2022-2023
Group Image (Poland)
2022
International Rescue Committee
2022
Prince Sultan University
2022
Abstract Granulysin, a protein located in the acidic granules of human NK cells and cytotoxic T cells, has antimicrobial activity against broad spectrum microbial pathogens. A predicted model generated from nuclear magnetic resonance structure related protein, lysin, suggested that granulysin contains four α helical bundle motif, with helices enriched for positively charged amino acids, including arginine lysine residues. Denaturation polypeptide reduced content 49 to 18% resulted complete...
To identify nuclear functions required for cytochrome c oxidase biogenesis in yeast, recessive mutants that are deficient were characterized.In complementation studies, 55 independently isolated placed into 34 groups.Analysis of the content subunits each mutant permitted definition three phenotypic classes.One class contains groups whose strains carry mutations COX4, COXSa, or COX9 genes.These genes encode IV, V,, and VIIa oxidase, respectively.Mutations these structural appear to affect...
Immune checkpoint inhibitors show remarkable antitumor activity across multiple tumor types, with approval of programmed death–1 (PD-1) for non–small cell lung cancer and melanoma. A recent clinical trial found median progression-free survival 11.5 months combined nivolumab plus ipilimumab therapy metastatic melanoma compared 6.9 (nivolumab alone) or 2.9 (ipilimumab alone).1 Nivolumab, a fully human IgG4 PD-1 antagonist antibody, ipilimumab, IgG1 cytotoxic T-lymphocyte–associated antigen 4...
Ultraviolet radiation (UVR) exposure and family history are major associated risk factors for the development of non-melanoma skin cancer (NMSC). The objective this study was to develop validate a multi-parameterized artificial neural network based on available personal health information early detection NMSC with high sensitivity specificity, even in absence known UVR history. 1997-2015 NHIS adult survey data used train our (NN) comprised 2,056 460,574 non-cancer cases. We extracted 13...
In Saccharomyces cerevisiae, the inner mitochondrial membrane protein cytochrome c oxidase is composed of nine polypeptide subunits. Six these subunits (IV, V, VI, VII, VIIa, VIII) are encoded by nuclear genome, and remaining three (I, II, III) DNA. We report here existence two nonidentical subunit V polypeptides, which separate genes within yeast genome. One gene, COX5a, encodes Va, normally found in preparations holocytochrome oxidase. The other COX5b, Vb, cross-reacts with anti-subunit Va...
<h3>Importance</h3> Linear porokeratosis features linear and whorled configurations of keratotic papules plaques, with coronoid lamellae present on histologic examination. Because manifests in the lines Blaschko representing dorsoventral migration patterns keratinocyte precursors, it has been suggested that postzygotic somatic mutation underlies disease. However, no genetic evidence supported this hypothesis to date. <h3>Objective</h3> To identify mutations associated porokeratosis....
In Saccharomyces cerevisiae, subunit V of the inner mitochondrial membrane protein complex cytochrome c oxidase is encoded by two nonidentical genes, COX5a and COX5b. Both genes are present as single copies in S. cerevisiae several other species. Nucleotide sequencing studies with COX5 reveal that they encode proteins 153 151 amino acids, respectively. Overall, coding sequences COX5b have nucleotide homologies 67 66%, They saturated for substitutions result a synonomous codon, indicating...
Using synthetic oligodeoxyribonucleic acid probes we have identified and isolated COX6, the structural gene for subunit VI of cytochrome e oxidase from Saccharomyces cerevisiae.The nucleotide sequence COX6 predicts an amino sequence, mature polypeptide, which is in perfect agreement with that determined previously.The se- quence also derived a precursor highly basic 40-amino NH2-terminal presequence.This has been observed after vitro translations programmed by yeast poly(A+) RNA.Northern...
At a 12-week follow-up appointment, dramatic improvement in the appearance of cutaneous lesions was noted, with near complete resolution patches and plaques small residual foci at prior larger nodular areas.The patient continued topical nitrogen mustard over 12 additional weeks (Figure 1B).However, subsequently developed ophthalmic symptoms, including vertical abduction defects, blurred vision, peripheral vision loss, attributed to ocular involvement NXG.The then began dexamethasone 20-mg...
Abstract Background Prior studies have shown the presence of immunohistochemical staining for SARS‐CoV‐2 spike protein (SP) in endothelial cells and eccrine epithelium acral perniosis classified as “COVID toes.” Yet, other been unable to detect RNA skin biopsies toes” by reverse‐transcriptase polymerase chain reaction testing. Objective In order address these apparently conflicting findings, we compared detection SP, through situ hybridization (ISH) vs immunohistochemistry (IHC), perniotic...
Leukocytoclastic vasculitis has been reported in the setting of COVID-19 infection and post-COVID-19 vaccination. We report a case IgA (IgAV) vaccination, with immunoglobulin A (IgA) immune deposits skin renal involvement. SARS-CoV spike protein immunohistochemical staining was negative. IgAV involvement is potential reaction to
The diagnosis of hidradenocarcinoma is difficult due to a combination factors including inconsistent nomenclature/ classification, rarity the neoplasm, and variable morphology cells composing neoplasm. Immunohistochemistry has not been previously performed on series hidradenocarcinomas. We evaluated six cases histologically immunohistochemically using antibodies gross cystic disease fluid protein-15 (GCDFP-15), carcino-embryonic antigen (CEA), epithelial membrane (EMA), S-100 protein,...
<h3>Importance</h3> Solid organ transplant recipients (SOTRs) have a 100-fold increased risk of squamous cell carcinoma (SCC), and they may develop more aggressive SCCs compared with immunocompetent individuals. <h3>Objective</h3> To compare outcomes associated behavior SCC in SOTRs high-risk patients. <h3>Design, Setting, Participants</h3> A retrospective cohort study 58 40 patients evaluated at the Yale Transplant Dermatology Clinic New Haven, Connecticut, who had least 1 confirmed...
Significance Chilblain diagnoses have increased during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and been attributed to viral infection a subsequent robust antiviral immune response. As result, providers managed these cases differently than idiopathic chilblains, which are associated with cold exposure. The relationship between chilblains SARS-CoV-2 infection, however, remains unclear as most patients do not test positive for SARS-CoV-2–specific PCR or...