A5036752348- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- melanin and skin pigmentation
- Nail Diseases and Treatments
- T-cell and Retrovirus Studies
- Artificial Intelligence in Healthcare and Education
- CAR-T cell therapy research
- Ethics in Clinical Research
- Patient-Provider Communication in Healthcare
- Cancer and Skin Lesions
- Diversity and Career in Medicine
- Dermatologic Treatments and Research
- Chronic Lymphocytic Leukemia Research
- Global Healthcare and Medical Tourism
- Fungal Infections and Studies
- Medicine and Dermatology Studies History
- Tumors and Oncological Cases
- Acne and Rosacea Treatments and Effects
- COVID-19 and healthcare impacts
- Salivary Gland Tumors Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Tattoo and Body Piercing Complications
Brown University
2021-2025
Providence College
2024
John Brown University
2023-2024
Lifespan
2024
Yale University
2017-2023
University of Cambridge
2017-2020
Howard Hughes Medical Institute
2018
Massachusetts General Hospital
2018
Harvard College Observatory
2012
Massey University
2007
Informed consent is integral to the practice of medicine. Most informed documents are written at a reading level that surpasses comprehension average American. Large language models, type artificial intelligence (AI) with ability summarize and revise content, present novel opportunity make used in forms more accessible American thus, improve quality consent. In this study, we experience largest health care system state Rhode Island implementing AI readability documents, highlighting one...
Despite the importance of informed consent in healthcare, readability and specificity forms often impede patients' comprehension. This study investigates use GPT-4 to simplify surgical introduces an AI-human expert collaborative approach validate content appropriateness. Consent from multiple institutions were assessed for simplified using GPT-4, with pre- post-simplification metrics compared nonparametric tests. Independent reviews by medical authors a malpractice defense attorney...
The chemical replication of RNA inside fatty acid vesicles is a plausible step in the emergence cellular life. On primitive Earth, simple protocells with ability to import nucleotides and short oligomers from their environment could potentially have replicated retained larger genomic oligonucleotides within spatially defined compartment. We previously shown that 5'-phosphoroimidazolide-activated "helper" enable nonenzymatic copying mixed-sequence templates solution, using mononucleotides....
<h3>Importance</h3> Linear porokeratosis features linear and whorled configurations of keratotic papules plaques, with coronoid lamellae present on histologic examination. Because manifests in the lines Blaschko representing dorsoventral migration patterns keratinocyte precursors, it has been suggested that postzygotic somatic mutation underlies disease. However, no genetic evidence supported this hypothesis to date. <h3>Objective</h3> To identify mutations associated porokeratosis....
While several systemic therapies are approved for cutaneous T cell lymphoma (CTCL), a non-Hodgkin of skin-homing cells that may involve lymph nodes and peripheral blood in advanced stages, relapses common. Mutational analysis CTCL has revealed frequent amplification the MYC oncogene, bromodomain extraterminal (BET) protein inhibitors have been shown to repress expression various malignancies. Towards potential novel therapy, we thus sought examine effect BET inhibition on vitro. Each four...
Abstract Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T lymphocytes that more likely to involve the peripheral blood in advanced stages. For such patients with disease, there are few available systemic treatment options, and prognosis remains poor. Exome sequencing studies CTCL have suggested therapeutic targets, including within JAK/STAT pathway, but JAK inhibition strategies may be limited by patient-specific mutational status. Because our recent research has highlighted...
Abstract Background Despite the importance of informed consent in healthcare, readability and specificity forms often impedes patients’ comprehension. Health literacy is linked to patient outcomes, making it essential address these issues. This study investigates use GPT-4 simplify surgical introduces an AI-human expert collaborative approach validate content appropriateness. Methods Consent from multiple institutions were assessed for simplified using GPT-4, with pre- post-simplification...
Human skin is exposed to visible light (VL; 400-700 nm) and long-wavelength ultraviolet A1 (UVA1) radiation (370-400 after the application of organic broad-spectrum sunscreens. The biologic effects these wavelengths have been demonstrated; however, a dose-response has not investigated. Ten subjects with Fitzpatrick phototype IV-VI were enrolled. Subjects irradiated 2 sources (80-480 J cm-2 ): one comprising VL less than 0.5% UVA1 (VL+UVA1) other pure VL. Skin responses evaluated for weeks...
Abstract The incidence of cutaneous T-cell lymphoma (CTCL) increases with age, and blood involvement portends a worse prognosis. To advance our understanding the development CTCL identify potential therapeutic targets, we performed integrative analyses paired single-cell RNA receptor (TCR) sequencing peripheral CD4+ T cells from patients to reveal disease-unifying features. malignant showed highly diverse transcriptomic profiles across patients, most displaying mature Th2 differentiation...
INTRODUCTION: Despite the importance of informed consent in healthcare, readability and specificity forms often impedes patients’ comprehension. Health literacy is linked to patient outcomes, making it essential address these issues. METHODS: Consent from multiple institutions were assessed for simplified using GPT-4, with pre- post-simplification metrics compared nonparametric tests. Independent reviews by medical authors a malpractice defense attorney conducted. Finally, GPT-4's potential...