A5090295087- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Medicine and Dermatology Studies History
- Cardiovascular Health and Risk Factors
- Melanoma and MAPK Pathways
- Retinoids in leukemia and cellular processes
- Emergency and Acute Care Studies
- Hospital Admissions and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Lung Cancer Diagnosis and Treatment
- Fungal Infections and Studies
- Global Public Health Policies and Epidemiology
- COVID-19 and healthcare impacts
- Ubiquitin and proteasome pathways
- Nail Diseases and Treatments
- Lung Cancer Treatments and Mutations
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Infection Control and Ventilation
- Erythropoietin and Anemia Treatment
- Radiomics and Machine Learning in Medical Imaging
- Dermatology and Skin Diseases
Ipsos (United Kingdom)
2024
Yale University
2019-2024
Massachusetts General Hospital
2024
Washington University in St. Louis
2017
Abstract Cutaneous T-cell lymphoma (CTCL) is a malignancy of skin-homing T lymphocytes that more likely to involve the peripheral blood in advanced stages. For such patients with disease, there are few available systemic treatment options, and prognosis remains poor. Exome sequencing studies CTCL have suggested therapeutic targets, including within JAK/STAT pathway, but JAK inhibition strategies may be limited by patient-specific mutational status. Because our recent research has highlighted...
Abstract The incidence of cutaneous T-cell lymphoma (CTCL) increases with age, and blood involvement portends a worse prognosis. To advance our understanding the development CTCL identify potential therapeutic targets, we performed integrative analyses paired single-cell RNA receptor (TCR) sequencing peripheral CD4+ T cells from patients to reveal disease-unifying features. malignant showed highly diverse transcriptomic profiles across patients, most displaying mature Th2 differentiation...
Previous studies demonstrate minimal utility of pre-operative imaging for low-risk melanoma; however, may be more critical patients with high-risk disease. Our study evaluates the impact peri-operative cross-sectional in T3b-T4b melanoma.Patients melanoma who underwent wide local excision were identified from a single institution (1/1/2005 - 12/31/2020). Cross-sectional was defined as body CT, PET and/or MRI perioperative period, following findings: in-transit or nodal disease, metastatic...
There remains a need for effective, durable therapies cutaneous T-cell lymphoma (CTCL), skin-homing non-Hodgkin (NHL) that in advanced stages may involve the blood and lymph nodes. Overall response rates approved CTCL agents range from ∼30% to 50%, with available oral limited bexarotene (a third-generation retinoid) vorinostat histone deacetylase inhibitor).1 The US Food Drug Administration recently agent venetoclax, selective inhibitor of B-cell 2 (BCL-2), chronic lymphocytic leukemia,...
<h3>Background:</h3> People with rheumatoid arthritis (RA), psoriatic (PsA), juvenile idiopathic (JIA), and axial spondyloarthritis (axSpA) are at risk for poor acute COVID-19 outcomes because of their disease, comorbidities, and/or treatments. Less is known about the impact infection 'long COVID' on post-acute in this vulnerable population, particularly regard to rheumatic disease activity, disability, quality life. <h3>Objectives:</h3> To examine association life people inflammatory...
8063 Background: Lymph nodal metastasis (LNM) plays a critical role in the prognosis and treatment strategy formulation for non-small cell lung cancer (NSCLC). Initial diagnosis typically involves CT scan, but its sensitivity detecting mediastinal LNM is limited, sometimes as low 51%. To improve detection, PET-CT, mediastinoscopy, Endobronchial ultrasound-guided transbronchial needle aspiration are employed, with sensitivities of 74%, 78%, 90%, respectively. The ability to anticipate from...
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL). Although it often has an indolent course, can progress to more aggressive CTCL forms. There sparse data in current literature describing specific clinical factors associated with in-hospital mortality mycosis patients. An understanding patients at greatest risk for aid developing recommendations prophylaxis and empirical management.
Objective The role of radiation therapy (RT) in melanoma has historically been limited to palliative care, with surgery as the primary treatment modality. However, adjuvant RT can be a powerful tool certain cases and its application increasingly explored recent years. aim this study is explore national patterns care associations surrounding use for stage III melanoma. Methods National Cancer Data Base (NCDB) was used identify patients who were diagnosed between 2004 2014. Exclusion criteria...
Background: In Honduras, the prevalence of cataracts, leading cause blindness, is rapidly mounting as associated chronic conditions, diabetes and hypertension, are on rise. The increased demand for cataract surgeries has had most severe impact rural communities, majority ophthalmologists serve cities. Additionally, owing to healthcare barriers, many dwellers have uncontrolled hypertension diabetes, consequently, denied surgical candidacy due risk. Thus, this investigation aims curb illness...