A5055763928- Cutaneous Melanoma Detection and Management
- Terahertz technology and applications
- Nonmelanoma Skin Cancer Studies
- CAR-T cell therapy research
- Genetically Modified Organisms Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Medical Image Segmentation Techniques
- Spectroscopy and Laser Applications
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- melanin and skin pigmentation
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Peripheral Artery Disease Management
- AI in cancer detection
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- 3D Shape Modeling and Analysis
- Cell Image Analysis Techniques
- Dermatological diseases and infestations
- Allergic Rhinitis and Sensitization
- Infrared Thermography in Medicine
- Superconducting and THz Device Technology
Oregon Health & Science University
2011-2025
VA Portland Health Care System
2024
The University of Texas Health Science Center at Houston
2023
The University of Texas MD Anderson Cancer Center
2023
Maine Medical Center
2023
Tufts University
2023
Kaiser Permanente Center for Health Research
2023
HealthONE
2023
Providence Portland Medical Center
2023
Emory University
2017-2018
Purpose Knowledge of tumor mutation status is becoming increasingly important for the treatment cancer, as mutation-specific inhibitors are being developed clinical use that target only sub-populations patients with particular genotypes. Melanoma provides a recent example this paradigm. We report here development, validation, and implementation an assay designed to simultaneously detect 43 common somatic point mutations in 6 genes (BRAF, NRAS, KIT, GNAQ, GNA11, CTNNB1) potentially relevant...
Abstract Activating NRAS mutations are found in 15% to 20% of melanomas. Immune therapies have become a mainstay advanced melanoma treatment. We sought evaluate whether tumor genotype (e.g., mutations) correlates with benefit from immune therapy melanoma. identified 229 patients treated [IL2, ipilimumab, or anti-programmed cell death-1/ligand-1 (PD-1/PD-L1)] at three centers and compared clinical outcomes following for without mutations. Of the melanoma, 60 had mutation, 53 BRAF 116...
Abstract Ipilimumab, a novel immune checkpoint inhibitor, is associated with long-term survival in approximately 20% of patients advanced melanoma and also being evaluated the adjuvant setting. With this growing cohort survivors, health outcomes, chronic toxicities, functional outcomes among survivors treated ipilimumab need to be defined. Using retrospective medical record abstraction, we disease status, immune- non–immune-related events, pharmacologic management symptoms, status melanoma,...
Ultraviolet radiation (UVR) exposure is the most important modifiable risk factor for skin cancer development. Although sunscreen and sun-protective clothing are essential tools to minimize UVR exposure, few studies have compared two modalities head-to-head. This study evaluates UV-protective capacity of four modern, textiles broad-spectrum, organic sunscreens (SPF 30 50). Sun Protection Factor (SPF), (UPF), Critical Wavelength (CW), % UVA- UVB-blocking were measured each fabric. UPF, CW, at...
Therapy for advanced melanoma has transformed during the past decade, but early detection and prognostic assessment of cutaneous (CM) remain paramount goals. Best practices screening use pigmented lesion evaluation tools gene expression profile (GEP) testing in CM to be defined.
Systemic steroids are commonly used to manage immune-related adverse events (irAEs), but it remains unclear whether they may undermine immune checkpoint inhibitor (ICI) therapy outcomes. Few studies have assessed the impact of steroid timing and its association with continuation or cessation ICI therapy.
Techniques for the coherent generation and detection of electromagnetic radiation in far infrared, or terahertz, region spectrum have recently developed rapidly may soon be applied vivo medical imaging. Both continuous wave pulsed imaging systems are under development, with terahertz being more common method. Typically a pump probe technique is used, picosecond pulses generated from femtosecond infrared laser pulses, using an antenna nonlinear crystal. After interaction subject either by...
<h3>Background:</h3> Primary care providers (PCPs) frequently address dermatologic concerns and perform skin examinations during clinical encounters. For PCPs who evaluate concerning lesions, dermoscopy (a noninvasive visualization technique) has been shown to increase the sensitivity for cancer diagnosis compared with unassisted examinations. Because no formal consensus existed on fundamental knowledge skills that should have respect detection, objective of this study was develop an expert...
Melanoma is one of the deadliest forms skin cancer but typically cured with surgical excision when detected early. As an access point to medical care, primary care providers (PCP) play integral role in early detection. However, limited time for examinations and dermatologic training may present barriers effective examination setting. a facet Oregon Health & Science University's War on Melanoma™ (WoM), our multi-pronged outreach initiative aims provide PCPs across free, convenient, melanoma...