A5005952726- Nanoparticles: synthesis and applications
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Laser-Ablation Synthesis of Nanoparticles
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Lipid metabolism and disorders
- Immune cells in cancer
- Gene expression and cancer classification
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Glioma Diagnosis and Treatment
- Cellular transport and secretion
- Epigenetics and DNA Methylation
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fungal Infections and Studies
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Yale University
2021-2025
Gateway Community College
2022
Banaras Hindu University
2022
University of Macau
2017-2021
City University of Macau
2020
BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is refractory disease due to its non-responsiveness current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative drivers, among Notch1 top candidate for accelerating TNBC by promoting epithelial-mesenchymal transition (EMT) and regulating cell cycle. Activation NOTCH1 suppresses mitotic catastrophe caused deficiency...
Nasopharyngeal carcinoma (NPC) is a malignant head and neck cancer type with high morbidity in Southeast Asia, however the pathogenic mechanism of this disease poorly understood. Using integrative pharmacogenomics, we find that NPC subtypes maintain distinct molecular features, drug responsiveness, graded radiation sensitivity. The epithelial (EC) subtype characterized by activations microtubule polymerization defective mitotic spindle checkpoint related genes, whereas sarcomatoid (SC) mixed...
The biocompatible gold nanoparticles (AuNPs) have great potential in the development of next-generation anti-cancer medicine. Here, AuNPs were synthesized through a biogenic method using red marine algae Champia parvula. Cp-AuNPs characterized and confirmed by various spectroscopic techniques. UV spectroscopy analysis found Surface Plasmon Resonance (SPR) peak at 550 nm. accurate size morphology identified Transmission Electron Microscope (TEM) Scanning (SEM) to be 20 nm round shape. crystal...
Green synthesized metal nanoparticles play a significant role in biomedical applications. This investigation focused on eco-friendly iron using marine brown algae Spatoglossum asperum which was evaluated for its anticancer and free radical scavenging activity against glioblastoma. The formation of confirmed the surface plasmon resonance (SPR) peak at 400 nm by UV visible Spectrum. X-ray diffraction spectroscopy analysis crystalline structure nanoparticles. Fourier Transform Infrared used to...
Abstract CD8 + T cells play an important role in anti-tumor immunity. Better understanding of their regulation could advance cancer immunotherapies. Here we identify, via stepwise CRISPR-based screening, that CUL5 is a negative regulator the core signaling pathways cells. Knocking out mouse significantly improves tumor growth inhibiting ability, with significant proteomic alterations broadly enhance TCR and cytokine effector functions. Chemical inhibition neddylation required by activation,...
Neutrophils are important innate immune cells with plasticity, heterogenicity, and functional ambivalency. While bone marrow is often regarded as the primary source of neutrophil production, roles extramedullary production in regulating plasticity heterogenicity autoimmune diseases remain poorly understood. Here, we report that lack wingless-type MMTV integration site family member 5 (WNT5) unleashes anti-inflammatory protection against colitis mice, accompanied by reduced colonic CD8+ T...
Angiopoietin-like 4 (ANGPTL4), a key protein involved in lipoprotein metabolism, has diverse effects. There is an association between Angptl4 and diabetic kidney disease; however, this not been well investigated. We show that both podocyte- tubule-specific ANGPTL4 are crucial fibrogenic molecules diabetes. Diabetes accelerates the phenotype control mice but mutant mice. The protective effect observed correlated with reduction stimulator of interferon genes pathway activation, expression...
Abstract Background Resistance to both naturally occurring anti-cancer immunity and immunotherapy is common in patients with aggressive non-small cell lung cancer (NSCLC). Recent studies indicate a role of loss the HLA class-I antigen presentation machinery (APM) protein β-2-microglobulin acquired resistance immune checkpoint blockers. However, mechanisms, functional consequences therapeutic potential APM defects NSCLC remain poorly understood. Methods Using multiplexed immunofluorescence,...
Background Germline mutation in BRCA 1 and BRCA2 ( ) is genetic predisposition for breast ovarian cancer. Identification of carriers a critical step to prevent treat the cancer carriers. Human variation has been well determined as ethnic-specific by studies Ashkenazi Jewish, Polish Icelandic populations 1990s. However, sufficient evidence lacking determine if also present Asia population, which largest most diversified modern humans. Our current study aims investigate Asian population....
The feasibility of personalized medicine for cancer treatment is largely hampered by costly, labor-intensive and time-consuming models drug discovery. Herein, establishing new pre-clinical to tackle these issues urgently demanded. Methods: We established a three-dimensional tumor slice culture (3D-TSC) platform incorporating label-free techniques time-course experiments predict anti-cancer efficacy validated the 3D-TSC model multiphoton fluorescence microscopy, RNA sequence analysis,...
// Barani Kumar Rajendran 1 and Chu-Xia Deng Cancer Research Centre, Faculty of Health Sciences, University Macau, Macau SAR, China Correspondence to: Deng, email: cxdeng@umac.mo Keywords: breast cancer, OBSCN gene, OBSCURIN, cell adhesion, EMT Received: May 25, 2017 Accepted: July 26, Published: August 23, ABSTRACT The giant multifunctional protein "OBSCURIN" is encoded by gene mostly expressed in cardiac other skeletal muscles responsible for myofibrils organization. Loss OBSCURIN affects...
Venomous reptiles especially serpents are well known for their adverse effects after accidental conflicts with humans. Upon biting humans these transmit arrays of detrimental toxins diverse physiological activities that may either lead to minor symptoms such as dermatitis and allergic response or highly severe blood coagulation, disseminated intravascular tissue injury, hemorrhage. Other complications like respiratory arrest necrosis also occur. Bungarotoxins a group closely related...
In this present study, marine red algae Hypnea valentiae capped silver nanoparticles (Hv-AgNPs) have been prepared through the green method and characterized by various analytical tools. The Hv-AgNPs were confirmed Ultraviolet-visible (UV) spectroscopy at 430 nm. X-ray diffraction (XRD) analysis affirmed face-centered cubic crystalline structure of Hv-AgNPs. Transmission electron microscope (TEM) revealed shape as spherical with an average size 10–45 Fourier Transform Infrared (FR-IR)...
Abstract The incidence of cutaneous T-cell lymphoma (CTCL) increases with age, and blood involvement portends a worse prognosis. To advance our understanding the development CTCL identify potential therapeutic targets, we performed integrative analyses paired single-cell RNA receptor (TCR) sequencing peripheral CD4+ T cells from patients to reveal disease-unifying features. malignant showed highly diverse transcriptomic profiles across patients, most displaying mature Th2 differentiation...