A5041310808- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immune cells in cancer
- NF-κB Signaling Pathways
- Advanced Glycation End Products research
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Natural Antidiabetic Agents Studies
- Immune Response and Inflammation
- Cellular transport and secretion
- Cancer Genomics and Diagnostics
- SARS-CoV-2 detection and testing
- interferon and immune responses
- Diverse Scientific Research Studies
- Systemic Sclerosis and Related Diseases
- Glycosylation and Glycoproteins Research
Yale University
2019-2025
Centre For Digestive Diseases
2021
Indian Institute of Advanced Research
2012-2020
Fas-associated death domain (FADD) is an adaptor protein that predominantly transduces the apoptosis signal from receptor (DR) to activate caspases, leading initiation of apoptotic signaling and coordinated removal damaged, infected, or unwanted cells. In addition its functions, FADD involved in pathways related autophagy, cell proliferation, necroptosis, cellular senescence, indicating versatile role survival proliferation. The subcellular localization intracellular expression play a...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of disease 2019 (COVID-19) pandemic which has been a topic major concern to global human health. The challenge restrain COVID-19 further compounded by emergence several SARS-CoV-2 variants viz. B.1.1.7, B.1.351, P1 and, B.1.617., show in-creased transmissibility and resistance towards vaccines therapies. Importantly, likelihood susceptibility infection among individuals with dysregulated immune response or...
Abstract Tumor Necrosis Factor-α canonically induces the activation of NF-κB and associated gene product cellular FLICE-like inhibitory protein (cFLIP L ) to promote cell survival. Previously, we demonstrated that ectopic expression Fas death domain (FADD) diminishes cFLIP transduces caspases-8 mediated apoptosis, independent FasL stimulation in HEK 293T cells. However, underlying molecular mechanism FADD ablation signaling determining fate or survival remains elusive. Here, explored a novel...
Proteases are hallmarks of various physiological processes and cellular signaling net-works that maintain homeostasis fate. This regulation is particularly medi-ated by carboxypeptidases, cysteine proteases, metalloproteases, which function cleaving peptide bonds, thereby modulating the activity proteins influencing their functional outcomes. play a regulatory role in processes, in-cluding cell growth, differentiation, death, immunity, inflammation. Protease influences terminal outcomes...
Abstract Background Resistance to both naturally occurring anti-cancer immunity and immunotherapy is common in patients with aggressive non-small cell lung cancer (NSCLC). Recent studies indicate a role of loss the HLA class-I antigen presentation machinery (APM) protein β-2-microglobulin acquired resistance immune checkpoint blockers. However, mechanisms, functional consequences therapeutic potential APM defects NSCLC remain poorly understood. Methods Using multiplexed immunofluorescence,...
Properly balancing microbial responses by the innate immune system through pattern recognition receptors (PRRs) is critical for intestinal homeostasis. Ring finger protein 186 (RNF186) genetic variants are associated with inflammatory bowel disease (IBD). However, functions E3 ubiquitin ligase RNF186 incompletely defined. We found that upon stimulation of PRR nucleotide-binding oligomerization domain containing 2 (NOD2) in human macrophages, localized to ER, formed a complex ER stress...
An alteration in susceptibility to apoptosis not only contributes promotion of malignancy but can also enhance drug resistance response anticancer therapies. HA14‐1 is a small molecule which has the potential inducing cancerous cells. manifests an antagonistic effect on antiapoptotic protein Bcl‐2 and consequently induces cell death various lines. However, it known generate ROS toxic cells upon decomposition. Elevated level responsible for oxidative stress other pathological consequences, if...
Highlights•LACC1 localizes to the ER upon PRR stimulation of human macrophages•LACC1 associates with ER-stress sensors and promotes UPR stimulation•LACC1-dependent stress is required for PRR-initiated downstream pathways•Common rare disease-risk variants in LACC1 show a reduction stressSummaryLACC1 genetic are associated multiple immune-mediated diseases. However, laccase domain containing-1 (LACC1) functions incompletely defined. We find that pattern-recognition receptor (PRR) NOD2,...
Dysregulated expression of Fas-associated death domain (FADD) is associated with the impediment various cellular pathways, including apoptosis and inflammation. The adequate cytosolic FADD critical to regulation cancer cell proliferation. Importantly, cells devise mechanisms suppress and, in turn, escape from signaling. Formulating strategies, for direct delivery proteins into a controlled manner, may represent promising therapeutic approach therapy. We chemically conjugated purified protein...
ABSTRACT Autophagy and apoptosis are two different physiological processes, which is required for the maintenance of cellular homeostasis. The associated proteins such as Bcl‐2 p53 have a close association with autophagic HMGB1 Beclin‐1 to modulate signaling. We demonstrate here involvement anti‐apoptotic protein cFLIP L in regulation autophagy during stress. found that ectopic expression decreases sensitivity HEK 293T cells against rapamycin H 2 O induced Notably, selective knockdown...
Endeavors to identify potentially protective variables for COVID-19 impact on certain populations have remained a priority. Multiple attempts been made attribute the reduced their Bacillus-Calmette-Guérin (BCG) vaccination coverage ignoring fact that effect of childhood BCG wanes within 5 years while most cases and deaths occurred in aged with comorbidities. Since supposed protection being investigated could come from heterologous 'trained immunity' (TI) conferred by exposure
Significance This study identifies a previously undefined role for the inflammatory bowel disease–associated gene RNF186 in innate immunity. is expressed human macrophages and promotes outcomes downstream of receptors responding to microbial products. Upon stimulation response receptors, contributes assembly ubiquitination signaling complex subsequent cytokine secretion antimicrobial pathway induction. Importantly, through different mechanisms, both rare (through impaired ubiquitination)...
The pathogenesis of inflammatory bowel disease (IBD) involves perturbation intestinal immune homeostasis in genetically susceptible individuals. A mutual interplay between epithelial cells (IECs) and gut resident microbes maintains a homeostatic environment across the gut. An idiopathic gastrointestinal (GI) complication triggers aberrant physiological stress epithelium peripheral myeloid cells, leading to chronic condition. Indeed, events endoplasmic reticulum (ER) mitochondria contribute...
Abstract Among people with HIV (PWH), non-small cell lung cancer (NSCLC) is increasing in incidence, presents more advanced disease, and portends a worse prognosis compared to the general NSCLC population. Despite effective control of viral replication antiretroviral therapy (ART), PWH have evidence immune dysfunction, it unknown whether these perturbations impact tumor microenvironment (TME) influence disease disparities.Here we preclinically model HIV-associated using MISTRG6-A2, humanized...