A5008200574- Neurobiology and Insect Physiology Research
- Peripheral Neuropathies and Disorders
- Invertebrate Immune Response Mechanisms
- Myasthenia Gravis and Thymoma
- Multiple Sclerosis Research Studies
- Insect Resistance and Genetics
- Insect and Arachnid Ecology and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect and Pesticide Research
- Insect Utilization and Effects
- T-cell and B-cell Immunology
- Insect-Plant Interactions and Control
- Physiological and biochemical adaptations
- Insect Pest Control Strategies
- Animal Behavior and Reproduction
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Antifungal resistance and susceptibility
- Aquaculture disease management and microbiota
- Complement system in diseases
- Cancer-related Molecular Pathways
- Aquaculture Nutrition and Growth
- Insect symbiosis and bacterial influences
- Tracheal and airway disorders
- Viral Infectious Diseases and Gene Expression in Insects
Zhejiang University
2015-2025
Beijing Tian Tan Hospital
2008-2025
Capital Medical University
2000-2025
Nanjing University
2025
Purple Mountain Laboratories
2025
Jiangnan University
2024-2025
Lanzhou University Second Hospital
2024
Sichuan Agricultural University
2024
Northeast Agricultural University
2024
Tianjin Medical University General Hospital
2024
Heat tolerance is a key parameter that affects insect distribution and abundance. Glyphodes pyloalis Walker (Lepidoptera: Pyralidae) devastating pest of mulberry in the main mulberry-growing regions can cause tremendous losses to sericulture by directly feeding on leaves transmitting viruses Bombyx mori. Moreover, G. shows prominent capacity for adaptation daily seasonal temperature fluctuations survive several hours under high temperature. To date, molecular mechanism underlying outstanding...
ABSTRACT Cyclin‐dependent kinase 9 (CDK9) is considered as an important target in the research of antitumor drugs. Taking CDK2/9 inhibitor CYC065 positive control and in‐house library compound ( 64 ) lead compound, four classes 22 compounds with 9H purine core structure were designed to establish structure–activity relationships (SAR). In general, SAR CDK9 inhibitors systematically described this paper, resulting discovery two B2 B5 further value. After conducting selectivity testing against...
Metabolic characterization of primary angiitis the central nervous system (PACNS) is crucial for understanding disease pathogenesis and progression mechanisms, but it has not been reported in patients. This study aimed to explore changes plasma metabolome during active remission phases PACNS identify potential biomarkers. We collected samples from 35 patients with 22 non-inflammatory as controls. Liquid gas chromatography-mass spectrometry were used analyze 63 57 metabolically. Meanwhile, we...
Acute kidney injury (AKI) is associated with a high mortality rate. Pathologically, renal ischemia/reperfusion (RIRI) one of the primary causes AKI, and hypoxia-inducible factor (HIF)-1α may play defensive role in RIRI. This study assessed 1α (HIF-1α)-mediated mitophagy protection against RIRI vitro vivo. The human tubular cell line HK-2 was used to assess hypoxia/reoxygenation (H/R)-induced through different assays, including western blotting, immunofluorescence staining, terminal...
Abstract Achieving dynamic switching among absorption (A), reflection (R), and transmission (T) states is not only essential for advancing the understanding of light‐metasurface interactions but also holds significant potential practical applications, such as selective electromagnetic shielding smart windows. However, at terahertz higher frequencies, implementing active elements in multilayer configurations presents challenges that are straightforward those encountered microwave range. In...
Abstract Diapause is a programmed developmental arrest process in insects. can occur at various stages of insect development and frequently restricted to specific stage within single species. In Bombyx mori , embryonic diapause elicited by the hormone (DH) DH receptor (DHR) strains. Nevertheless, regulatory mechanism through which BmDHR functions as G protein‐coupled (GPCR), exert other physiological nondiapause silkworms, remains unclear. this study, we found that had 7 alternative splice...
Objectives To assess the efficacy and safety of rituximab (RTX) in Chinese patients with primary angiitis central nervous system (PACNS). Methods Herein, we present outcomes 8 who received RTX for PACNS. Seven underwent a brain biopsy showing vasculitis, while remaining patient had digital subtraction angiogram clinical findings highly suggestive vasculitis. Clinical evaluation, laboratory tests, imaging modalities were performed during initial administration follow-up. The Expanded...
Abstract Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated peripheral nervous system disease. CD4 + CD25 T regulatory cells (Tregs) have been unequivocally shown to be critical in maintaining immune tolerance and preventing auto‐immune diseases by suppressing self‐reactive cells. Thus, we hypothesized that the numbers and/or function of Tregs would deranged during progressive or relapse phases CIDP. The number was determined flow cytometry according their...
Autoantigen administration via nasal mucosal tissue can induce systemic tolerance more effectively than oral in a number of experimental autoimmune diseases, including Ab-mediated myasthenia gravis, murine model gravis. The mechanisms underlying induction are not clear. In this study, we show that acetylcholine receptor (AChR) C57BL/6 mice, before immunizations with AChR adjuvant, results delayed onset and reduced muscle weakness compared control mice. were associated decreased AChR-specific...
Abstract CTLA-4 appears to be a negative regulator of T cell activation and is implicated in cell-mediated autoimmune diseases. Experimental myasthenia gravis (EAMG), induced by immunization C57BL/6 mice with acetylcholine receptor (AChR) adjuvant, an autoantibody-mediated disease model for human (MG). The production anti-AChR Abs MG EAMG dependent. In the present study, we demonstrate that anti-CTLA-4 Ab treatment enhances responses AChR, increases production, provokes rapid onset severe...
<b><i>Objective:</i></b> We investigated the contribution of several cytokines in pathogenesis first-onset neuromyelitis optica spectrum disorder (NMOSD) and determined differences between aquaporin 4 immunoglobulin G (AQP4-IgG)-positive AQP4-IgG-negative subtypes. <b><i>Methods:</i></b> enrolled 18 NMOSD (10 AQP4-IgG-positive 8 AQP4-IgG-negative) multiple sclerosis (MS) patients, whose serum cerebrospinal fluid (CSF) samples were collected...