A5047459900- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Neonatal Health and Biochemistry
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Microbial bioremediation and biosurfactants
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Alcohol Consumption and Health Effects
- Radioactive element chemistry and processing
- Particle physics theoretical and experimental studies
- Ophthalmology and Eye Disorders
- Retinal Diseases and Treatments
- Cannabis and Cannabinoid Research
- Photosynthetic Processes and Mechanisms
- High-Energy Particle Collisions Research
- HVDC Systems and Fault Protection
- Breastfeeding Practices and Influences
- Pelvic floor disorders treatments
- Phytochemical Studies and Bioactivities
- Circadian rhythm and melatonin
- Glutathione Transferases and Polymorphisms
- Statistical Mechanics and Entropy
- Hepatitis B Virus Studies
- High-Voltage Power Transmission Systems
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2020-2025
Xi'an University of Architecture and Technology
2023-2024
Wuxi Taihu Hospital
2024
Zhejiang Lab
2024
Ministry of Education of the People's Republic of China
2024
Nanjing Medical University
2024
Hebei Academy of Agriculture and Forestry Sciences
2024
Target (United States)
2024
Shanxi University
2021-2023
S-Nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in cardiovascular disease. Aortic aneurysm and dissection are high-risk diseases without an effective cure. The aim of this study was to determine the role SNO Septin2 macrophages aortic dissection.
Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, many studies have reported presence severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) conjunctival sac patients infected with this virus, several displaying symptoms viral conjunctivitis. However, to our best knowledge, there is no in-depth report on course COVID-19 complicated by relapsing conjunctivitis or keratoconjunctivitis.A 53-year-old man confirmed developed left eye approximately 10 days after...
Heme oxygenase (HO) catalyzes the oxygen-dependent degradation of heme to biliverdinIXα, CO, and free iron ion via three sequential monooxygenase reactions. Although distinct active-site structure HO from cytochrome P450 families suggests unique distal protein machinery activate molecular oxygen, mechanism key amino acid for oxygen activation have not been clear. To investigate functionality highly conserved polar acids in helix HO-1, we prepared alanine mutants: T135A, R136A, D140A, S142A,...
Circulating microRNAs (miRNAs) have been detected in various types of cancer and proposed as novel biomarkers for diagnosis treatment. Until recently, however, no studies had comprehensively examined circulating miRNAs oral cancer. The current study used an ultra-sensitive genome-wide miRNA array to investigate changes plasma from five patients with ten healthy individuals. Results indicated that there were only a few miRNAs, including miR-223, miR-26a, miR-126, miR-21, up-regulated A...
Background: Deep brain stimulation (DBS) is a novel neurosurgical approach that has great potential for treating many neurological and psychiatric problems. The study aimed to evaluate the efficacy, safety, mechanisms of DBS in rodent models various disorders.Method: A comprehensive literature search was conducted using PubMed, Scopus, Web Science, EMBASE databases. Preclinical studies employing Parkinson's disease, depression, addiction, epilepsy, other disorders were included. Data on...
AIM: To compare analysis of the impact high altitude on corneal endothelial cells, and prognosis in patients with cataract surgeries. METHODS: Totally 265 plateau surgeries performed between January 2019 July 2022 (average altitude=3000 m), 524 plain 2020 were included. The propensity score matching (PSM) method was applied to match basic information both regions a 1:1 basis. Corneal cell density (ECD), coefficient variation (CV), hexagonal ratio (HEX), duration surgery, pre- postoperative...
Redox status affects various cellular activities, such as proliferation, differentiation, and death. Recent studies suggest pivotal roles of reactive oxygen species not only in pathogenesis under oxidative insult but also intracellular signal transduction. Glutathione is present several millimolar concentrations the cytoplasm has multiple regulation homeostasis. Two enzymes, γ-glutamylcysteine synthetase glutathione synthetase, constitute de novo synthesis machinery, while reductase involved...
Impaired mitochondrial dynamics have been identified as a significant contributing factor to reduced neurogenesis under pathological conditions. However, the relationship among dynamics, neurogenesis, and spatial memory during normal development remains unclear. This study aims elucidate role of mitophagy in mediated by development.
Heme oxygenase (HO) catalyzes the oxidative degradation of heme utilizing molecular oxygen and reducing equivalents. In photosynthetic organisms, HO functions in biosynthesis such open‐chain tetrapyrroles as phyto‐chromobilin phycobilins, which are involved signal transduction for light responses harvesting photosynthesis, respectively. We have determined first crystal structure a HO‐1 from organism, Synechocystis sp. PCC 6803 (Syn HO‐1), complex with at 2.5 Å resolution. Heme–Syn shares...
Phycobiliproteins, light-harvesting proteins in cyanobacteria, red algae, and cryptophytes, contain phycobilin pigments. Phycobilins are synthesized from biliverdin, which is produced by the oxidative cleavage of heme porphyrin ring catalyzed oxygenase (HO). Two paralogs ho (ho1 ho2) have been identified genome cyanobacterium, Synechocystis sp. PCC 6803. The recombinant both (Syn HO-1 Syn HO-2) possess vitro degradation activity. We determined crystal structures HO-2 complex with (heme-Syn...
Abstract Uveitis, the pathologic condition of inflammation uvea, frequently leads to severe vision loss and blindness. S100A8 is a calcium-binding protein which mainly expresses in granulocytes monocytes plays prominent role regulation inflammatory processes immune response. Here, we determined S100A8-positive cells acute anterior uveitis (AAU) keratitis. In rat models endotoxin (lipopolisaccharide, LPS) -induced (EIU) keratitis, increased significantly iris-ciliary body cornea as well...
Purpose . This retrospective study aimed at comparing the efficacy and safety of toric spherical orthokeratology lenses in treatment patients with moderate to high astigmatism. Methods Fifty adolescents myopia astigmatism (≥1.50 D) who underwent consecutive for least 1 year were included this study. The group comprised 25 subjects (25 eyes, 11 M, 14 F; age, 10.67 ± 1.46 years) fitted lenses. subjects, 11.45 1.63 traditional as a control. Corneal topography, visual acuity, axial length,...
An efficient bacterial expression system of cyanobacterium Synechocystis sp. PCC 6803 heme oxygenase gene, ho‐1 , has been constructed, using a synthetic gene. A soluble protein was expressed at high levels and highly purified, for the first time. The binds equimolar free hemin to catabolize bound ferric‐biliverdin IX α in presence oxygen reducing equivalents, showing activity. During reaction, verdoheme intermediate is formed with evolution carbon monoxide. Though both ascorbate...
We cloned a cDNA for Drosophila melanogaster homologue of mammalian heme oxygenase (HO) and constructed bacterial expression system truncated, soluble form D. HO (DmΔHO). The purified DmΔHO degraded hemin to biliverdin, CO iron in the presence reducing systems such as NADPH/cytochrome P450 reductase sodium ascorbate, although reaction rate was slower than that HOs. Some properties DmHO, however, are quite different from other known Thus bound stoichiometrically hemin–enzyme complex like HOs,...