A5115848343- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Fuel Cells and Related Materials
- Mitochondrial Function and Pathology
- RNA regulation and disease
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Reproductive System and Pregnancy
- Mycobacterium research and diagnosis
- Extracellular vesicles in disease
- Signaling Pathways in Disease
Harbin Medical University
2021-2025
Chengdu Research Base of Giant Panda Breeding
2024
State Forestry and Grassland Administration
2024
Ministry of Education of the People's Republic of China
2024
Sun Yat-sen University
2022
Sun Yat-sen University Cancer Center
2022
G protein-coupled receptors play a critical role in atrial fibrillation (AF). Spexin is novel ligand of galanin (GALRs). In this study, we investigated the regulation spexin and GALRs on AF underlying mechanisms.
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channels remains unexplored. Our preliminary data showed lncRNA- Dachshund homolog 1 ( lncDach1 ) can bind to dystrophin, which drove us investigate if regulate by interfering with dystrophin. Western blot and immunofluorescent staining cardiomyocyte-specific transgenic...
<title>Abstract</title> Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. The study aims to explore whether lncRNA-DACH1(lncDACH1) can regulate the distribution by binding dystrophin and participate ventricular arrhythmogenesis. LncDACH1 was confirmed bind dystrophin. Cardiomyocyte-specific transgenic overexpression lncDACH1(lncDACH1-TG) reduced opposite data were collected from lncDACH1 cardiomyocyte conditional knockout...
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. Long noncoding RNAs (lncRNAs) are involved the regulation cardiac ion channels, while their influence on sodium channels remains unexplored. Our preliminary data showed lncRNA- Dachshund homolog 1 ( lncDach1 ) can bind to dystrophin, which drove us investigate if regulate by interfering with dystrophin. Western blot and immunofluorescent staining cardiomyocyte-specific transgenic...
Dystrophin is a critical interacting protein of Nav1.5 that determines its membrane anchoring in cardiomyocytes. The study aims to explore whether lncRNA-DACH1(lncDACH1) can regulate the distribution by binding dystrophin and participate ventricular arrhythmogenesis. LncDACH1 was confirmed bind dystrophin. Cardiomyocyte-specific transgenic overexpression lncDACH1(lncDACH1-TG) reduced opposite data were collected from lncDACH1 cardiomyocyte conditional knockout (lncDACH1-CKO) mice. Moreover,...