A5101759063- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Head and Neck Cancer Studies
- Bladder and Urothelial Cancer Treatments
- Inflammasome and immune disorders
- RNA modifications and cancer
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Head and Neck Surgical Oncology
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Enzyme Production and Characterization
- Indian History and Philosophy
- Space Science and Extraterrestrial Life
- Plant tissue culture and regeneration
- Neonatal Health and Biochemistry
- Lung Cancer Diagnosis and Treatment
- Plant biochemistry and biosynthesis
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
First Affiliated Hospital of Harbin Medical University
2023-2024
Harbin Medical University
2023-2024
Henan Normal University
2022-2023
Sun Yat-sen University
2022
Sun Yat-sen University Cancer Center
2022
Children's Hospital of Fudan University
2008-2022
Anyang Institute of Technology
2020-2021
Shanxi Agricultural University
2020
Xuzhou Medical College
2009-2018
Affiliated Hospital of Xuzhou Medical College
2015-2016
Understanding the intricate relationship between prognosis, immune function, and molecular markers in bladder cancer (BC) demands sophisticated analytical methods. To identify novel biomarkers for predicting prognosis function BC patients, we combined weighted gene co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) regression analysis. This was conducted using data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Ultimately,...
Abstract YARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, biological functions bladder cancer remains be proven. We analysed variations YARS1 expression survival using multiple data sets, including TCGA‐BLCA, GSE13507 cancer‐specific tissue microarrays. Furthermore, we explored transcriptome data. Our findings revealed noteworthy correlation between immune infiltration cancer, as determined XCELL algorithm...
Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival. However, the predictive value biological function of PRPF19 bladder urothelial carcinoma (BLCA) require further investigation. Methods In this study, we utilized transcriptomic data cancer tissue microarrays to identify high expression BLCA, suggesting its potential as prognostic biomarker. To gain better understanding immune...
Abstract Bladder cancer (BC) is the most common urinary tract malignancy. Identifying biomarkers that predict prognosis and immune function in patients with BC can enhance our understanding of its pathogenesis provide valuable guidance for diagnosis treatment. Our findings indicate increased ITGB1 expression associated higher clinical grade stage, establishing as an independent prognostic risk factor BC. Enrichment analysis revealed was linked to extracellular matrix. The experimental...
Abstract Smoking is a well‐known risk factor for non‐small‐cell lung cancer (NSCLC) and bladder urothelial carcinoma (BLCA). Despite this, there has been no investigation into prognostic marker based on smoking‐related genes that could universally predict prognosis in these cancers correlate with immune checkpoint therapy. This study aimed to identify differential NSCLC BLCA, analyse their roles patient therapy through subgroup analyses, shed light PRR11 as crucial gene both cancers. By...
Mutations in ATPase phospholipid transporting 8B1 (ATP8B1) can lead to familial intrahepatic cholestasis type 1 (FIC1) deficiency, or progressive 1. The rarity of FIC1 deficiency has largely prevented a detailed analysis its natural history, effects predicted protein truncating mutations (PPTMs), and possible associations serum bile acid (sBA) concentrations surgical biliary diversion (SBD) with long-term outcome. We aimed provide insights by using the largest genetically defined cohort...
Background This pilot trial is designed to determine whether PET/CT-guided radiotherapy dose escalation can improve local control while minimizing toxicity for the treatment of locally advanced nasopharyngeal carcinoma. Methods 67 patients were randomized into three arms: conventional chemoradiotherapy (group A), CT-guided B) and C). Radiotherapy was delivered using simultaneous modulated accelerated radiation therapy (SMART) technique in dose-escalation arms. Patients received concurrent...
A new type of parallel, label-free target detection based on the combination chip electrophoresis and a nanoparticle optical biosensor is reported.
Artemisia argyi is an important medicinal plant widely utilized for moxibustion heat therapy in China. The terpenoid biosynthesis process A. speculated to play a key role conferring its value. However, the molecular mechanism underlying remains unclear, part because reference genome of unavailable. Moreover, full-length transcriptome has not yet been sequenced. Therefore, this study, de novo sequencing 's root, stem, and leaf tissues was performed obtain those candidate genes related...
An acidic endo-beta-1,4-glucanase, denoted CelA4 ( approximately 48 kDa), was purified from thermoacidophilic Alicyclobacillus sp. A4. Two internal peptides of showed strong sequence identity to the acidocaldarius cellulase precursor and contained conserved domain catalytic region glycoside hydrolase family 51 beta-1,4-glucanases, N-terminal three other had no close glucanase or relatives, suggesting that enzyme might be novel. broad substrate specificity, exhibited maximum activity at 65...
The objective of the present study was to investigate association between thyroid gland-dosimetric parameters and hypothyroidism induced by intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC). A total 52 NPC treated Department Radiation Oncology Affiliated Hospital Xuzhou Medical University, from May 2008 December 2016 were retrospectively enrolled divided into two groups based on function: euthyroid hypothyroid groups. clinical or dosimetric analyzed. Females...
Abstract Heat shock protein member 8 (HSPA8) is one of the most abundant chaperones in eukaryotic cells, but its biological roles bladder cancer (BC) are largely unclear. First, we observed that HSPA8 was both cell lines and tissues BC, HSPA8‐high group had poorer T stages overall survival (OS) than HSPA8‐low TCGA patients. Next, when knocked down BC growth migration abilities were significantly decreased, apoptosis rates increased, Ki67 fluorescence intensity decreased cells. Moreover,...
N6-methyladenosine (m6A) is the most frequent RNA modification in mammals, and its role bladder cancer (BC) remains rarely revealed.
The biological roles of immune-related genes (IRGs) in bladder cancer (BC) need to be further elucidated.To elucidate the predictive value IRGs for prognosis and immune escape BC.We comprehensively analyzed transcriptomic clinical information 430 cases, including 19 normal 411 BC patients from TCGA database, verified 165 cases GSE13507 dataset. risk model was constructed based on by applying LASSO Cox regression exploring relationship between score prognosis, gene mutations, patients.We...
To make sure the feasibility with (18F)FDG PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment.Chose 11 patients in III~IVA treated functional image-guided IMRT and absolute relative Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx IBA detachable phantom. Drawing outline making treatment plan were different imaging techniques (CT PET/CT). The dose distributions various regional...
Integrin αvβ3/α6β1 are crucial in the transduction of intercellular cancer information, while their roles prostate (PCa) remain poorly understood. Here, we systematically analyzed transcriptome, single nucleotide polymorphisms (SNPs) and clinical data 495 PCa patients from TCGA database verified them 220 GEO patients, qPCR was used to validate expression model genes our patients. First, found that integrin negatively correlated with most immune cell infiltration functions closely associated...