A5021472496- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pediatric Urology and Nephrology Studies
- Menopause: Health Impacts and Treatments
- Cancer, Hypoxia, and Metabolism
- Phytoestrogen effects and research
- Kidney Stones and Urolithiasis Treatments
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Trace Elements in Health
- Renal and related cancers
- Heat shock proteins research
North China University of Science and Technology
2025
Harbin Medical University
2010-2024
First Affiliated Hospital of Harbin Medical University
2009-2024
Zhongda Hospital Southeast University
2021-2023
Harbin University
2019
National University of Singapore
2017
Understanding the intricate relationship between prognosis, immune function, and molecular markers in bladder cancer (BC) demands sophisticated analytical methods. To identify novel biomarkers for predicting prognosis function BC patients, we combined weighted gene co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) regression analysis. This was conducted using data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Ultimately,...
Background Angiogenesis, the process of forming new blood vessels from pre-existing ones, plays a crucial role in development and advancement cancer. Although blocking angiogenesis has shown success treating different types solid tumors, its relevance prostate adenocarcinoma (PRAD) not been thoroughly investigated. Method This study utilized WGCNA method to identify angiogenesis-related genes assessed their diagnostic prognostic value patients with PRAD through cluster analysis. A model was...
Abstract Bladder cancer (BC) is the most common urinary tract malignancy. Identifying biomarkers that predict prognosis and immune function in patients with BC can enhance our understanding of its pathogenesis provide valuable guidance for diagnosis treatment. Our findings indicate increased ITGB1 expression associated higher clinical grade stage, establishing as an independent prognostic risk factor BC. Enrichment analysis revealed was linked to extracellular matrix. The experimental...
Background Pre-mRNA processing factor 19 (PRPF19) is an E3 ligase that plays a crucial role in repairing tumor-damaged cells and promoting cell survival. However, the predictive value biological function of PRPF19 bladder urothelial carcinoma (BLCA) require further investigation. Methods In this study, we utilized transcriptomic data cancer tissue microarrays to identify high expression BLCA, suggesting its potential as prognostic biomarker. To gain better understanding immune...
Abstract YARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, biological functions bladder cancer remains be proven. We analysed variations YARS1 expression survival using multiple data sets, including TCGA‐BLCA, GSE13507 cancer‐specific tissue microarrays. Furthermore, we explored transcriptome data. Our findings revealed noteworthy correlation between immune infiltration cancer, as determined XCELL algorithm...
Abstract Smoking is a well‐known risk factor for non‐small‐cell lung cancer (NSCLC) and bladder urothelial carcinoma (BLCA). Despite this, there has been no investigation into prognostic marker based on smoking‐related genes that could universally predict prognosis in these cancers correlate with immune checkpoint therapy. This study aimed to identify differential NSCLC BLCA, analyse their roles patient therapy through subgroup analyses, shed light PRR11 as crucial gene both cancers. By...
Background/Aims: MiR-30a-5p, a member of the microRNA-30 family (miR-30), is known to function as tumor suppressor in several different cancers. However, expression levels, biological function, and underlying mechanisms miR-30a-5p renal cell carcinoma (RCC) remain unclear. Glucose-regulated protein78 (GRP78) common cancer biomarker promotes growth survival cells. The GRP78 has been reported be modulated by miR-30a neurons. In this study, profile clear (ccRCC) its effect on ccRCC through...
At present, there is a lack of research on the correlation between cumFPG and digestive malignancies, previous cohort studies have not considered competitive risk death which may overestimate impact related factors. To explore malignant tumors system. In this study, 53,747 participants who had undergone 3 consecutive physical examinations since 2006 were collected. Finally, total included in study. According to grouping method studies, was divided into 4 groups according quartile. Cox...
In order to improve the adhesion between a PGA scaffold and islet cells, it is necessary find suitable method modify scaffold. this study, surface was modified by plasma, polylysine coating plasma combined with (P-P-PGA). The of examined, stretchability infiltration were also tested. Then, treated under optimal treatment conditions selected co-culture rat survival activity cells on untreated P-P-PGA examined via MTT method. Rhodamine staining DAPI used detect number adhered four groups...
Long noncoding RNAs (lncRNAs) have been identified as important factors in cancer biology and are deregulated many cancers. The present study aimed to determine the expression roles of lncRNA
Abstract Heat shock protein member 8 (HSPA8) is one of the most abundant chaperones in eukaryotic cells, but its biological roles bladder cancer (BC) are largely unclear. First, we observed that HSPA8 was both cell lines and tissues BC, HSPA8‐high group had poorer T stages overall survival (OS) than HSPA8‐low TCGA patients. Next, when knocked down BC growth migration abilities were significantly decreased, apoptosis rates increased, Ki67 fluorescence intensity decreased cells. Moreover,...
2540 Background: E7080 is a potent, orally administered, receptor tyrosine kinase inhibitor of KDR, VEGFR1, VEGFR3, FGFR2, and RET. Antiangiogenic antiproliferative activity were seen in human cancer xenograft models, suggesting that may be promising anticancer agent. We report the MTD DLT determination administered continuous twice daily (bid) schedule. Methods: Escalating doses ranging from 0.1 mg to 12 bid studied patients (pts) with advanced solid tumors. Tumor assessments made after...
N6-methyladenosine (m6A) is the most frequent RNA modification in mammals, and its role bladder cancer (BC) remains rarely revealed.
This study aimed to evaluate the efficacy and safety of ultra-low-dose estradiol plus dydrogesterone for vasomotor symptoms in postmenopausal women China (trial registration CTR20160689).A total 332 patients were randomized continuous combined 0.5 mg + 2.5 or placebo 12 weeks. The primary endpoint was change number hot flushes per day from baseline end treatment. Secondary endpoints included moderate-to-severe day, menopausal quality life.Between treatment, mean -5.9 (95% confidence interval...
Background: Prostate cancer (PCa) is the leading cause of death in men and has poor therapeutic outcomes. Methods: A novel endostatin 33 peptide was synthesized by adding a specific QRD sequence on basis 30 (PEP06) with antitumor activity. Then, bioinformatic analysis subsequent experiments were performed to validate function this peptide. Results: We found that polypeptides significantly inhibited growth, invasion metastasis promoted apoptosis PCa vivo or vitro, which more significant than...
Objective This study aimed to compare the efficacy and safety of oral transdermal estradiol in alleviating menopausal symptoms.
Elements are vital in airway mucosal physiology and pathology, but their distribution levels the mucosa remain unclear. This study uses state-of-the-art nuclear microscopy facility to map quantify multiple elements histology sections of nasal from patients with polyps or inverted papilloma. Our results demonstrate that P Ca most abundant distinct difference between epithelial subepithelial regions; more importantly, our reveal decreased amounts Cu Zn remodeled epithelium as compared normal...
The biological roles of immune-related genes (IRGs) in bladder cancer (BC) need to be further elucidated.To elucidate the predictive value IRGs for prognosis and immune escape BC.We comprehensively analyzed transcriptomic clinical information 430 cases, including 19 normal 411 BC patients from TCGA database, verified 165 cases GSE13507 dataset. risk model was constructed based on by applying LASSO Cox regression exploring relationship between score prognosis, gene mutations, patients.We...
Integrin αvβ3/α6β1 are crucial in the transduction of intercellular cancer information, while their roles prostate (PCa) remain poorly understood. Here, we systematically analyzed transcriptome, single nucleotide polymorphisms (SNPs) and clinical data 495 PCa patients from TCGA database verified them 220 GEO patients, qPCR was used to validate expression model genes our patients. First, found that integrin negatively correlated with most immune cell infiltration functions closely associated...