A5013806170- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Appendicitis Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal disorders and treatments
- Intraperitoneal and Appendiceal Malignancies
- Inflammatory Biomarkers in Disease Prognosis
- Biliary and Gastrointestinal Fistulas
- Medical Imaging and Pathology Studies
- Digestive system and related health
- Bone and Dental Protein Studies
- Genetic factors in colorectal cancer
- Astronomical Observations and Instrumentation
- Abdominal vascular conditions and treatments
- Hernia repair and management
- Neuroblastoma Research and Treatments
- Gastroesophageal reflux and treatments
- Lymphoma Diagnosis and Treatment
Shinshu University
2020-2025
Shinshu University Hospital
2022
Matsumoto City Hospital
2021-2022
National Hospital Organization
2021-2022
Toho University
2020
Toho University Omori Medical Center
2020
Abstract Aim The purpose of this study was to evaluate whether parameters obtained from gadoxetate disodium‐enhanced magnetic resonance imaging (EOB‐MRI) could predict intrahepatic tumor recurrence in patients who underwent curative hepatectomy for hepatocellular carcinoma (HCC). Methods This included 208 EOB‐MRI before HCC. mean signal intensity the liver (L20) and spleen (S20) preoperative EOB‐MRI, liver‐to‐spleen ratio (LSR) calculated these values as: LSR = L20/S20. association value...
Although most cancer deaths are caused by metastasis, there no effective therapeutic approaches. This study describes the efficacy of a short synthetic mRNA (s-mRNA) designed sequence non-vesicular extracellular IL1β-mRNA found in pre-metastatic lung tumor-bearing mice. The administration s-mRNA inhibits murine metastasis inducing innate and adaptive immune systems. binds to ZC3H12D, an RNA-binding protein on natural killer cells cytotoxic T lymphocytes. ZC3H12D-s-mRNA complex translocated...
Intrahepatic cholangiocarcinoma (iCCA) has been newly subclassified into two different subtypes: large-duct (LD) type and small-duct (SD) type. However, many cases are difficult to subclassify, there is no consensus regarding subclassification criteria. LD expresses the highly sensitive diagnostic marker S100 calcium-binding protein P (S100P), while SD lacks markers. We identified osteopontin (OPN) as a for This study aimed develop new criteria LD-type SD-type iCCA. retrospectively...
Hiatal hernia is defined by the permanent or intermittent prolapse of any abdominal structure into chest through diaphragmatic esophageal hiatus. Prolapse stomach, intestine, transverse colon, and spleen relatively common, but herniation pancreas a rare condition. We describe case acute pancreatitis bile duct dilatation secondary to massive hiatal pancreatic body tail.An 86-year-old woman with who complained epigastric pain vomiting was admitted our hospital. Blood tests revealed...
Abstract Background Juvenile polyposis syndrome (JPS) is an autosomal dominant, inherited disorder characterized by multiple hyperproliferative polyps of the gastrointestinal tract, particularly colon, rectum, and stomach. SMAD4 mutations are frequently associated with stomach; condition causes severe bleeding hypoproteinemia, which may progress to dysplasia adenocarcinoma formation. We report our experience first case total gastrectomy pancreaticoduodenectomy following two partial...
Background. Although chronic kidney disease (CKD) after liver transplantation (LTx) is a common complication in adults, its long-term significance pediatric LTx remains unclear. We examined the decades-long transition of renal function and revealed risk factors for late-onset CKD single-center retrospective cohort 117 recipients who survived >5 y. Methods. The estimated glomerular filtration rate (eGFR) stages were calculated using serum creatinine. Risk factor analysis was performed 41...
Malignant lymphoma is a rare form of gallbladder malignancy. Most these malignancies are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas; however, Burkitt's the extremely rare, and only two previous reports available in literature. Herein, we report case mimicking adenocarcinoma.An 83-year-old man with no abdominal complaints was found to have tumor periportal lymph node enlargement on computed tomography (CT) performed for hypertension screening. His...
The aim of this study was to evaluate the safety urgent laparoscopic cholecystectomy (Lap-C) for grade II acute cholecystitis (AC) in high-risk patients who were defined by Tokyo Guideline 18 as having age-adjusted Charlson comorbidity index ≥6 or American Society Anesthesiologists physical status classification (ASA-PS) ≥ 3, compared with elective Lap-C following percutaneous transhepatic gallbladder drainage (PTGBD).In 73 AC underwent from January 2012 March 2021, 35 identified high-risk;...
Liver metastasis is the most common form of distant spread colorectal cancer. Despite oncological and surgical advances, only about 25% patients are eligible to undergo resection. As liver has a limited resectable volume, tumor reduction remnant hypertrophy critical importance in treating initially unresectable cancer metastasis. Associated partition portal vein ligation for staged hepatectomy (ALPPS) allows rapid within short period been reported be useful recent years.A 29-year-old woman...
Abstract Background and Aim Post‐hepatectomy liver failure (PHLF) after major hepatopancreatoduodenectomy (HPD) is a challenge to overcome. However, the appropriate target proportion of future remnant (pFLR) prevent severe PHLF in HPD remains uncertain. This study aimed determine minimum pFLR required for safe HPD. Methods retrospective involved 48 patients. We assessed function scores (pFLR × albumin‐bilirubin [ALBI] / albumin‐indocyanine green evaluation [ALICE]/plasma clearance rate...
Cholangiocarcinoma has a poor prognosis, and resection is the only curative treatment. Pembrolizumab, programmed death receptor 1 inhibitor, proven effective against unresectable or metastatic solid tumors with high microsatellite instability (MSI-H) tumor mutation burden (TMB-H). In present case, pembrolizumab treatment was initiated after standard chemotherapy for MSI-H TMB-H intrahepatic cholangiocarcinoma. Intrahepatic necrosis perforated abdominal cavity. Emergency surgery performed,...
症例は60歳女性，粘血便を主訴に大腸内視鏡検査，注腸造影検査を施行したところ上部直腸-直腸S状部(Ra-Rs）に1型腫瘍を認め，肛門管にかかる下部直腸(Rb-P）に2型腫瘍を認めた．生検結果はともに扁平上皮癌であった．以上よりRb-Pの約2cmの2型腫瘍，Ra-Rsの約6cmの1型腫瘍に対し，平成17年8月腹会陰式直腸切断術を施行した．病理検査結果ではRb-P腫瘍は低分化型扁平上皮癌，mp, ly2, v2であった．Ra病変は主座が粘膜下にあり，粘膜面には陰窩が残存して比較的保たれていること，これら組織が類似していることから下部直腸扁平上皮癌の上部直腸への壁内転移と判断した．われわれは下部直腸扁平上皮癌が上部直腸に同時性壁内転移をきたし，切除しえた稀な症例を経験したので報告する．
A diverticulum is a relatively common finding that generally discovered incidentally; it most commonly observed in the colon, followed by duodenum. However, duodenal perforation (DDP) rare complication. Due to its rarity, diagnosis often challenging and appropriate treatment remains unclear, possibly contributing high mortality rate. Traditionally, surgical repair primary mode of treatment. with recent advancements medical technology, conservative management such as bowel rest endoscopic...
Post-appendectomy mucus-filled lesions, arising from appendiceal remnant tissue, are an exclusively rare clinical entity. We report a case of lesion rising distal viable tip as late complication appendectomy. A 48-year-old man presented with 2-week history right buttock and lower quadrant abdominal pain. He had previously undergone appendectomy 23 years ago. Radiological examination showed cystic lateral to the colon prominent tubular structure. According past operative note, was lost...
The inability to pass stool for a prolonged period can lead the formation of fecaliths, which occurs most often in colon or rectum. Although large fecaliths serious life-threatening complications, detailed process their is unknown. This report describes 65-year-old woman who presented with melena due ischemic proctitis caused by fecalith. On computed tomography, fecalith showed unique multilayered calcification sign. We successfully dismantled and removed transanally, assisted traction...
症例は55歳の女性で，腹部膨満感を主訴に受診し，精査で肝S8に15 mm大の結節を認めた．同病変は造影CT，MRIでリング状の濃染を示し，FDG-PETで強い集積を認めたが他の原発病変および遠隔転移は認めなかった．混合型肝癌の診断で手術の方針となり腹腔鏡下肝S8部分切除術を施行した．病理組織所見では核・細胞質比の高い小円形の異型細胞が充実性～集塊性に増殖しており，間葉系細胞マーカーvimentinが陽性のため肝原発肉腫と診断された．各種マーカーについて免疫染色検査を行った結果，既存の肉腫の分類のいずれにも当てはまらず分類は困難であった．術後経過は良好で，術後15か月の現在無再発生存中である．肝原発肉腫は非常にまれな疾患である．組織型は免疫染色検査所見によって分類されるが，今回，我々は既存の分類のいずれにも該当しない肝原発肉腫の1切除例を経験したので報告する．
症例は79歳の女性で，両側肺野の結節影に対して施行した胸部CTにて，偶然胆囊腫瘍が指摘され当科紹介となった．胆囊底部に漸増性に造影される5 cmを超える腫瘍性病変を認めた．腫瘍の芯に相当する部位に石灰化が認められた．周囲への浸潤傾向は認めず，粘液の産生も疑われた．以上より，胆囊内乳頭状腫瘍（intracholecystic papillary neoplasm；以下，ICPNと略記）と診断した．胆囊床切除および胆囊摘出術，センチネルリンパ節切除術を施行した．切除標本肉眼所見は胆囊腔内に粘液の貯留と白色の乳頭状隆起性病変を認め，壊死した部位を伴っていた．病理組織学的検査所見ではlow grade dysplasiaとhigh dysplasiaの混在したICPNで，ごく一部に浸潤癌を認めた．組織学的亜分類は，肉眼所見とMUC染色によりgastric typeと診断した．また，#12cリンパ節に微小転移を認めたため後日追加で2群リンパ節郭清を施行した．術前診断可能であったICPNは，ほとんど報告がなくまれであるため報告する．
The utility of the SAND balloon catheter in laparoscopic cholecystectomy for acute cholecystitis (AC) remains unclear.A retrospective cohort study patients who underwent emergency at Shinshu University was performed to evaluate efficacy cases AC (SAND utilization: Group S, n = 44; non-utilization: non-S, 47).The duration surgery significantly shorter S than non-S (p .031). Despite comparable incidences blood transfusions two groups, intraoperative loss less .013). incidence postoperative...
Children requiring liver transplantation generally have severe growth retardation. Recipients experience posttransplantation catch-up growth, although some show short adult heights. We aimed to determine decades-long trends and risk factors for height following transplantation.