A5031356729- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Heart Failure Treatment and Management
- Genomics, phytochemicals, and oxidative stress
- Potassium and Related Disorders
- Diabetes Treatment and Management
- Systemic Lupus Erythematosus Research
- Chronic Myeloid Leukemia Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Histone Deacetylase Inhibitors Research
- Platelet Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Systemic Sclerosis and Related Diseases
- Stroke Rehabilitation and Recovery
- Rheumatoid Arthritis Research and Therapies
- Autophagy in Disease and Therapy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Muscle Physiology and Disorders
General Hospital of Shenyang Military Region
2023-2025
Northeastern University
2023-2024
Universidad del Noreste
2023
Abstract Background CREG1 (cellular repressor of E1A‐stimulated genes 1) is a protein involved in cellular differentiation and homeostasis regulation. However, its role skeletal muscle satellite cells regeneration poorly understood. This study aimed to investigate the myogenesis regeneration. Methods RNA sequencing data (GSE8479) was analysed from Gene Expression Omnibus database (GEO, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi ). We generated Creg1 knockdown specific overexpression mice...
Abstract Advanced diabetic cardiomyopathy (DCM) patients are often accompanied by severe peripheral artery disease. For with DCM combined foot ulcer (DFU), there currently no good therapeutic targets and drugs. Here, we investigated the underlying network of molecular actions associated occurrence these two complications. The datasets were downloaded from Gene Expression Omnibus (GEO) database. We performed enrichment protein–protein interaction analyses, screened for hub genes. Construct...
Abnormal megakaryocyte maturation and platelet production lead to platelet-related diseases impact the dynamic balance between hemostasis bleeding. Cellular repressor of E1A-stimulated gene 1 (CREG1) is a glycoprotein that promotes tissue differentiation. However, its role in megakaryocytes remains unclear. In this study, we found CREG1 protein expressed platelets was decreased patients with thrombocytopenia. A cytosine arabinoside-induced thrombocytopenia mouse model established, mRNA...
Abstract Benzopyrene (B[a]P) is a well-known carcinogen that can induce chronic inflammation and fibrosis in the liver, leading to liver disease upon exposure. Nonalcoholic steatohepatitis (NASH) condition characterized by fat accumulation, inflammation, fibrosis, often resulting hepatocellular carcinoma (HCC). In this study, we aimed investigate intricate connections between B[a]P exposure, NASH, HCC. Through comprehensive bioinformatics analysis of publicly available gene expression...
Abstract Benzopyrene (B[a]P) is a widely recognized carcinogen that, upon chronic exposure, can induce inflammation and fibrosis in liver tissue, ultimately resulting disease. Nonalcoholic steatohepatitis (NASH) condition characterized by fat accumulation, inflammation, fibrosis, often hepatocellular carcinoma (HCC). This study aimed to investigate the intricate connections between B[a]P NASH, HCC. Through comprehensive bioinformatics analysis, we identified differentially expressed genes...
Introduction: Type 2 diabetes is prevalent worldwide. Cardiovascular complications in patients with include diabetic cardiomyopathy (DCM). Ubiquitin-conjugating enzyme E2 I (UBC9) the only SUMO-E2 that plays a key role cardiomyocytes. Hypothesis: The present study aimed to elucidate and mechanism of action UBC9 development DCM. Methods: We established myocardial-specific knockout (UBC9-CKO) adeno-associated virus-overexpressing mouse models. Additionally, model DCM was using high-fat diet...