A5011996219- Building Energy and Comfort Optimization
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Architecture and Computational Design
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- MicroRNA in disease regulation
- Design Education and Practice
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- BIM and Construction Integration
- Circular RNAs in diseases
- COVID-19 diagnosis using AI
- Wind and Air Flow Studies
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Innovations in Concrete and Construction Materials
- Urban Heat Island Mitigation
- Cancer-related gene regulation
- Genetic and Kidney Cyst Diseases
- Congenital limb and hand anomalies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Taiyuan University of Technology
2015-2025
Harbin Medical University
2014-2024
Nanjing University
2010-2022
Ministry of Education of the People's Republic of China
2019-2022
China Astronaut Research and Training Center
2022
Affiliated Hospital of Hangzhou Normal University
2022
Chinese Academy for Environmental Planning
2022
Xinzhou Teachers University
2019
Shanghai University of Traditional Chinese Medicine
2005
Southeast University
1999
Purpose: Investigate the role of regulator chromosome condensation 2 (RCC2) on lung adenocarcinoma (LUAD) metastasis.Experimental Design: Clinical specimens were used to assess impact RCC2 LUAD metastasis. Mouse models, cytobiology, and molecular biology assays performed elucidate function underlying mechanisms in LUAD.Results: expression was frequently increased LUADs (88/122, 72.13%). It confirmed by analysis a larger cohort TCGA RNA-seq data containing 488 58 normal tissues (P < 0.001)....
Integrated 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is widely performed for staging solitary pulmonary nodules (SPNs). However, the diagnostic efficacy of SPNs based on PET/CT not optimal. Here, we propose a method detection that can differentiate malignant and benign with few false-positives.Our proposed combines features positron-emission (PET) computed (CT). A dynamic threshold segmentation was used to identify lung parenchyma in CT images...
Background Pneumoconiosis staging is challenging due to the low clarity of X-ray images and small, diffuse nature lesions. Additionally, scarcity annotated data makes it difficult develop accurate models. Although clinical text reports provide valuable contextual information, existing works primarily focus on designing multimodal image-text contrastive learning tasks, neglecting high similarity pneumoconiosis imaging representations. This results in inadequate extraction fine-grained...
Previously, we identified 3 overlapping regions showing loss of heterozygosity (LOH, R1–R3 from 11 to 30 cM) on chromosome 17 in 45 primary gastric cancers (GCs). The data indicated the presence tumor suppressor genes (TSGs) involved GC. Among putative TSGs these regions, HIC1 (in SR1) and TOB1 SR3) remain be examined By immunohistochemistry (IHC), methylation-specific PCR (MSP) western blot, evaluated expression regulation status for protein We narrowed down deletion intervals defined five...
Abstract Background Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of are not yet fully understood. Methods We performed genomic, transcriptional proteomic analyses human colon cancer cells with sequentially increasing levels MTX-resistance. Results The genomic evolved three phases (pre-amplification, homogenously staining region (HSR) extrachromosomal DNA (ecDNA)). confirm that...
Human non–small cell lung cancer (NSCLC) is one of the most common malignancies in modern world. Its recurrence mainly due to its ability invade and metastasize. However, precise mechanism for tumor development metastasis still not fully understood. To shed light on cancer, human giant carcinoma lines 95D with high metastatic potential 95C low were selected this study. The 2 originated from same parental share a similar genetic background. In current study, we identified 3 differentially...
Using performance-based optimisation to explore unknown design solutions space has become widely acknowledged and considered an efficient approach designing high-performing buildings.However, the lack of diversity in defined by parametric model often confines search process a family similar variants.In order overcome this weakness, paper presents two massing generation algorithms based on additive subtractive form principles.By abstracting rule these principles, can generate diverse building...
The tumor suppressor gene CDKN2A generates at least three different transcriptional variants, each of which is thought to encode a suppressor. However, the inhibitory activities these variants have not yet been compared in same cells. Protein therapy known several advantages over therapy. Thus, investigation exogenous protein molecule most effective may yield meaningful information regarding protein-based cancer therapy.The effects p16INK4a, p14ARF and p12 were studied human lung cell line...
Sei-1 is an oncogene capable of inducing double minute chromosomes (DMs) formation. DMs are hallmarks amplification and contribute to oncogenesis. However, the mechanism formation remains unelucidated.DMs significantly increased during serial passage in vivo gradually decreased following culture vitro. micro nuclei (MN) was found be responsible for reduction. Of DMs-carrying genes, Met markedly amplified, overexpressed highly correlated with Inhibition signaling number reduced genes. We...
Abstract Gene amplification chiefly manifests as homogeneously stained regions (HSRs) or double minutes (DMs) in cytogenetically and extrachromosomal DNA (ecDNA) molecular genetics. Evidence suggests that gene is becoming a hotspot for cancer research, which may be new treatment strategy cancer. DMs usually carry oncogenes chemoresistant genes are associated with progression, occurrence prognosis. Defining the structure of will facilitate understanding mechanism tumorigenesis. In this study,...
The integration of optimization algorithms and building performance simulation tools make it possible to carry out performative design or performance-driven design, which aims guide the synthesis process results continuously improve design.However, associated research work windrelated is still deficient, resulting from lack applicable interface time consumption.Meanwhile, in industrial realm, aero-dynamics fluid-dynamics behaviour production under development has been vastly analysed...
Abstract Background Synpolydactyly type 1 (SPD1), also known as syndactyly II, is an autosomal dominant limb deformity generally results in webbing of 3rd and 4th fingers, duplication or 5th toes. It most commonly caused by mutation HOXD13 gene. In this study, a five-generation Chinese family affected with SPD1 disease were collected. We tried to identify the pathogenic variations associated involved family. Methods used whole genome sequencing (WGS) variant which was later confirmed...
TSPAN12, a member of the tetraspanin family, has been highly connected with pathogenesis cancer. Its biological function, however, especially in ovarian cancer (OC), not well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation
This paper presents an evolutionary design toolkit for performance-based building massing optimisation.The is aimed to assist architects in exploring a wide range of alternatives guided by various performance objectives, thereby encouraging incorporate optimisation enriching ideation at the outset process.The implemented Rhino-Grasshopper environment and includes components diversity-guided algorithm two pre-defined parametric models capable generating designs.The can yield diverse variants...
Lung cancer is one of the most malignant tumors worldwide with a high mortality rate, which has not been improved since several decades ago. FOX gene family members have reported to play extensive roles in regulating many biological processes and disorders. In order clarify contribution lung biology, we performed expression profiling analysis from FOXA FOXR cell lines tissue specimens by Real-time PCR, western blot immunohistochemistry analysis. We found that FOXE1 was only over-expressed...
Identifying the driving factors of soil environmental quality is critical in raising countermeasures for managing environment efficiently and precisely. In 2018, China issued risk control standards to divide into three classes meet demands management. However, there a lack knowledge this new standard. An intensive field-sampling research (2598 top-soil samples were analyzed) was conducted agricultural land Hubei province, central China, find pollutants based on According standard, proportion...
The complex interactive relationship between wind flow and building design poses a great challenge in architectural design.Recent research has been conducted to combine Computational Fluid Dynamics (CFD) computational optimization solve the problem.However, due time-consuming simulation process assertion-oriented application, such CFD-based frameworks are not easy integrate with architects' early-stage exploration.To address these issues, this paper proposes an agile wind-driven massing...
Being a rich source of geometric forms, Chinese lattice designs have interested some scholars.With shape grammar and algorithmic approaches, the generation has been achieved except for that irregular interdependently structured iceray designs.This paper introduced an approach to solve problem.The algorithm includes crack-track presetting, cracktrack cutting, crack correcting, bad disposing, realized by programming with Grasshopper VB script component.