A5100622746- Parasitic infections in humans and animals
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Plant Virus Research Studies
- Aquaculture disease management and microbiota
- Virus-based gene therapy research
- interferon and immune responses
- Soybean genetics and cultivation
- RNA Research and Splicing
- Heat shock proteins research
- Plant Disease Resistance and Genetics
- RNA regulation and disease
- Congenital Anomalies and Fetal Surgery
- Multiple Sclerosis Research Studies
- Parasitic Infections and Diagnostics
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Heavy metals in environment
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Ultrasound and Hyperthermia Applications
- Reproductive System and Pregnancy
Lanzhou Veterinary Research Institute
2019-2025
Sichuan University
2020-2025
Chinese Academy of Agricultural Sciences
2009-2025
Nanjing University
2025
Nanjing General Hospital of Nanjing Military Command
2025
Stony Brook University
2006-2025
Shihezi University
2025
Jiangxi Maternal and Child Health Hospital
2023-2024
Fox Chase Cancer Center
2010-2024
China Agricultural University
2022-2023
Premature ovarian insufficiency (POI) refers to the decline of function before age 40. POI causes a reduction in or loss female fertility, accompanied by different degrees menopausal symptoms, which increases risk chronic diseases related early menopause and seriously affects patients' quality life health. It is conservatively estimated that at least one million prepubertal girls women reproductive China are iatrogenic caused radiotherapy chemotherapy every year. With development medical...
Glioblastoma is the most malignant and common intrinsic brain tumor, but molecular mechanism of glioma pathophysiology poorly understood. Recent data have shown that microRNAs regulate expression several genes associated with human cancer. In present study, function miR-34c in cells was analyzed. It demonstrated miR-34c-3p miR-34c-5p were downregulated gliomas, by performing qPCR on tumor tissues from patients cell lines, compared normal a glial line. Furthermore, found to be inversely...
Glial cells have increasingly been implicated as active participants in the pathogenesis of neurological diseases, but critical pathways and mechanisms controlling glial function secondary non-cell autonomous neuronal injury remain incompletely defined. Here we use models Alexander disease, a severe brain disorder caused by gain-of-function mutations GFAP, to demonstrate that misregulation GFAP leads activation mechanosensitive signaling cascade characterized Hippo pathway consequent...
Predicting the phenotypes of missense mutations uncovered by large-scale sequencing projects is an important goal in computational biology. High-confidence predictions can be aid focusing experimental and association studies on those most likely to associated with causative relationships between mutation disease. As developing these methods further, we have derived a set random enzymatic domains human cystathionine beta synthase. This enzyme dimeric protein that catalyzes condensation serine...
Huntington9s disease (HD) is caused by a polyglutamine expansion within the huntingtin (Htt) protein. Both loss of function normal Htt and gain toxic polyglutamine-expanded mutant protein have been proposed to be responsible for HD, although molecular mechanisms involved are unclear. We show that neuroprotective in both HD-related unrelated model systems. Neuroprotection mediated its sequestration histone deacetylase-3 (HDAC3), known promote neuronal death. In contrast Htt, interacts poorly...
Abstract Background Taenia pisiformis is one of the most common intestinal parasites in canines, and leads to serious economic losses rabbit breeding industry. Exosome-like vesicles from play crucial roles host-parasite interactions by transferring cargo host cells modulating immunological response through inducing production host-derived cytokines. Nevertheless, mechanism which exosome-like T. cysticercus regulate macrophage immune remains unknown. Methods Using ultracentrifugation, we...
AFE activates p53, acting on apoptosis, autophagy, senescence, and metastasis, induces mitochondrial dysfunction.
Abstract Metacestodiasis is an infectious disease caused by the larval stage of cestode parasites. This poses a serious health hazard to wildlife, livestock, and humans, it incurs substantial economic losses impacting safety livestock industry, quality meat production, public security. Unfortunately, there currently no available molecular diagnostic method capable distinguishing cysticercus‐ Echinococcus ‐derived microRNAs (miRNAs) from other helminthes hosts in plasma metacestode‐infected...
Viral infections seriously affect the health of organisms including humans. Now, more and researchers believe that microRNAs (miRNAs), one members non-coding RNA family, play significant roles in cell biological function, disease occurrence, immunotherapy. However, miRNAs virus infection (entry replication) cellular immune response remain poorly understood, especially low vertebrate fish. In this study, based on established virus-cell model, Singapore grouper iridovirus (SGIV)-infected cells...
Ulcerative colitis (UC) is a non-specific inflammatory bowel illness characterized by intestinal mucosal barrier degradation, inflammation, oxidative damage, and gut microbiota imbalances. Rosa roxburghii Tratt Fruit extract (RRTE) was extracted from fruit, exhibiting an excellent prevention effect against UC; RRTE could prevent the damage of DSS-induced human normal colonic epithelial (NCM 460) cells, especially in cell viability morphology, damage. Additionally, UC mice, limit increasing...
The aim of this study was to understand the trends myopia prevalence among children and adolescents in Shihezi, China. This a cross-sectional using data from 2018 2023 Vision Surveillance Research Program for Students Shihezi City. Describe with 95% CIs 31,265 urban rural areas, by sex age. rate chain growth spherical equivalent refraction different ages were described development myopia. A total mean age 11,91 ± 3.67 years included study. overall 50.93%(15924/31265, CI: 50.38 - 51.49%)....