A5041749057- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Erythrocyte Function and Pathophysiology
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Mitochondrial Function and Pathology
- Genomic variations and chromosomal abnormalities
- Geophysical Methods and Applications
- Microtubule and mitosis dynamics
- Biotin and Related Studies
- PARP inhibition in cancer therapy
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Heme Oxygenase-1 and Carbon Monoxide
- Carcinogens and Genotoxicity Assessment
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Neurological disorders and treatments
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Geophysical and Geoelectrical Methods
- Botulinum Toxin and Related Neurological Disorders
Institute of Hematology & Blood Diseases Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Harbin Medical University
2017-2024
Chinese Academy of Sciences
2022-2023
University of Chinese Academy of Sciences
2022-2023
Institute of Biophysics
2022-2023
Beijing Children’s Hospital
2022
Capital Medical University
2022
State Key Laboratory of Brain and Cognitive Science
2022
Czech Academy of Sciences, Institute of Biophysics
2022
Aggregation of α-synuclein (oligomeric α-syn) has been considered as the pathological hallmark Parkinson's disease (PD) and multiple system atrophy (MSA). Studies showed oligomeric α-syn/total α-syn ratio was increased in saliva patients with PD, suggesting that seeding activity salivary may be a novel biomarker for diagnosis PD MSA.This study aimed to evaluate diagnostic value MSA.A total 75 18 MSA, 36 nonneurodegenerative healthy control subjects underwent real-time quaking-induced...
As the only cell type responsible for oxygen delivery, erythrocytes play a crucial role in supplying to hypoxic tissues, ensuring their normal functions. Hypoxia commonly occurs under physiological or pathological conditions, and understanding how adapt hypoxia is fundamental exploring mechanisms of diseases. Additionally, investigating acute chronic mountain sickness caused by plateaus, which are naturally environments, will aid study In recent years, increasingly developed proteomics...
Gene amplification, which involves the two major topographical structures double minutes (DMs) and homegeneously stained region (HSR), is a common mechanism of treatment resistance in cancer initiated by DNA double-strand breaks. NHEJ, one DSB repair pathways, involved gene amplification as we demonstrated previously. However, involvement homologous recombination, another pathway, remains to be explored. To better understand association between HR detected activity DM- HSR-containing...
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial damage in proteinopathy, little is known about how imported mitochondria. In addition, whether caused by mislocalization of or a side effect mitochondria-mediated degradation remains to investigated. Here, our bioinformatical analyses reveal that mitophagy receptor gene FUNDC1 co-expressed with TDP-43, both expression correlated genes associated import pathway brain samples patients diagnosed proteinopathy....
Abstract Background Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of are not yet fully understood. Methods We performed genomic, transcriptional proteomic analyses human colon cancer cells with sequentially increasing levels MTX-resistance. Results The genomic evolved three phases (pre-amplification, homogenously staining region (HSR) extrachromosomal DNA (ecDNA)). confirm that...
Abstract Sei-1 is a potential oncogene that plays an important role in promoting genomic instability. Double minute chromosomes (DMs) are hallmarks of gene amplification and contribute to tumorigenesis. Defects the DNA double-strand break (DSB) repairing pathways can lead amplification. To date, mechanisms governing formation DMs induced by not fully understood. We established NIH-3T3 cell line. RNA-sequencing was used identify key characteristics differentially expressed genes. Metaphase...
The ground–airborne frequency–domain electromagnetic (GAFDEM) method is a recently developed rapid detection approach for underground structures. However, the conventional apparent resistivity imaging in this cannot meet requirements of high precision and efficiency 3D targets. Therefore, we introduce divergence tipper vector (DTV) to solve problem with two orthogonal sources. First, define DTV GAFDEM method, then, analyze characteristics, advantages, principles using models. Incorporating...
Extrachromosomal DNAs (ecDNAs), also known as double minutes (DMs), can induce a fast increase in gene copy numbers and promote the development of cancer, including drug resistance. MutS homolog 3 (MSH3), key protein mismatch repair, has been indicated to participate regulation DNA double‑strand break (DSB) which reported be associated with formation ecDNAs. However, it remains unclear whether MSH3 influence resistance via ecDNAs cancer. In present study, high expression was observed...
Abstract Motivation Alternative splicing is an important mechanism to generate transcriptomic and phenotypic diversity. Existing methods have limited power detect orthologous isoforms. Results We develop a new method, EGIO, exons isoforms from two species. EGIO uses unique exonic regions construct exon groups, in which process dynamic programming strategy used do alignment. could cover all the coding within genes. A comparison between ExTraMapper shows that more with conserved sequence...
Summary TMEM56 , a gene coding transmembrane protein, is abundantly expressed in erythroid cells. Despite this, its role erythropoiesis has not been well characterized. In this study, we sought to clarify the function of development, focusing specifically on involvement haem biosynthesis and cell cycle progression. To do used CD34 + haematopoietic stem cells derived from umbilical cord blood differentiated them into an ex vivo model. Our results indicate that loss disrupts impairs...
Copy number variation (CNV) is one of chromosomal structure variations. CNVs can influence gene expression by changing copy numbers genes, functional SNPs, promoters and so on, while changes may have an effect on phenotypes biological adaptation. Cancer evolutionary disease, which a threat to human health. Up now, there are mainly two cancer theories: clonal evolution neutral evolution, very importance in these theories. Here, we will review the roles evolution. Key words: CNVs; Gene...
Background: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation pathologic activities of autoimmune diseases，suggesting HIF1α may be involved immune dysregulation patients thrombocytopenia (ITP). Aims: The purpose this study was to evaluate whether single nucleotide polymorphisms (SNPs) HIF1A gene are susceptibility ITP its clinical prognosis including incidence chronic...
Mitochondria damage is an early event in a series of neurodegenerative diseases. Although TDP-43, RNA binding protein (RBP), translocated to mitochondria through TOM-TIM complexes and causes mitochondrial damage, other factors that regulate the translocation process remain unclear. Here, we have collected set frontal cortical RNA-seq data from control samples TDP-43 proteinopathy patients GEO database. Gene co-expression network analyses indicate FUNDC1 expression positively correlated with...