A5004293373- Sarcoma Diagnosis and Treatment
- Earthquake Detection and Analysis
- Cancer-related molecular mechanisms research
- earthquake and tectonic studies
- Gut microbiota and health
- Wound Healing and Treatments
- Barrier Structure and Function Studies
- MicroRNA in disease regulation
- Clinical Nutrition and Gastroenterology
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Seismology and Earthquake Studies
- Cancer-related gene regulation
- Adrenal and Paraganglionic Tumors
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Dermatologic Treatments and Research
- Epigenetics and DNA Methylation
- Connexins and lens biology
- Surgical Sutures and Adhesives
- Graphene and Nanomaterials Applications
- Selenium in Biological Systems
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Oral microbiology and periodontitis research
Shenzhen Center for Disease Control and Prevention
2017-2024
National Institute of Hospital Administration
2024
Suizhou Central Hospital
2021-2022
Shihezi University
2017-2021
Army Medical University
2017-2020
Southwest Hospital
2017-2019
Huazhong University of Science and Technology
2019
Shanghai Sixth People's Hospital
2019
Background/Aims: Short-chain fatty acids (SCFAs) are the major energy resources of intestinal epithelial cells. It has been reported that SCFAs can repair dysfunction barrier, however, underlying mechanisms still not fully understood. Here, we investigated stimulative and protective effects on barrier function possible mechanisms. Methods: To investigate function, Caco-2 monolayers were exposed to acetate, propionate, butyrate respectively or simultaneously without with lipopolysaccharide...
Tight junction barrier is critical to intestinal homeostasis. Applying antibiotics treat infections common in clinical practice, which may affect microbiota. Intestinal microbiota dysbiosis involved the occurrence of some gastrointestinal diseases. Therefore, this study was aimed investigate influence on tight and possible underlying mechanisms. Healthy adult female C57BL/6 mice were treated with a broad-spectrum antibiotic cocktail for 14 days. 16S rDNA Illumina sequencing headspace gas...
The intestinal barrier integrity is crucial for maintaining homeostasis, and the mechanisms of disruption induced by burn injury remain obscure. This study was aimed to investigate changes microbiota function in burned mice further comprehend burn-induced dysfunction.Samples were from inflicted with 30% total body surface area (TBSA) full-thickness burns. permeability, tight junction proteins expressions, zonula occludens-1 (ZO-1) localization, inflammatory cytokines short-chain fatty acids...
The disruption of intestinal barrier plays a vital role in the pathophysiological changes after severe burn injury, however underlying mechanisms are poorly understood. Severe causes tight junction (TJ) barrier. Previous studies have shown that endoplasmic reticulum (ER) stress and autophagy closely associated with impairment mucosa. Thus, we hypothesize ER likely involved injury-induced epithelial dysfunction. Mice received 30% total body surface area (TBSA) full-thickness burn, were...
Severe burn injury induces intestinal barrier dysfunction; however, the underlying mechanisms remain elusive. Our previous studies have shown that epithelial tight junction (TJ) dysfunction is associated with both endoplasmic reticulum (ER) stress and autophagy in severely burned mice, but precise role of ER burn-induced TJ needs to be determined. In this study, female C57/BL6 mice were assigned randomly either sham or 30% total body surface area (TBSA) full-thickness burn. The effects on...
The epithelial-to-mesenchymal transition (EMT) and the reverse process (the mesenchymal-to-epithelial [MET]) have been shown to be associated with tumor cell invasion metastasis in different carcinomas. EMT MET recently play a key role pathogenic processes of sarcomas, which are completely from those However, definitive roles tumorigenesis synovial sarcomas remain unknown. Here, we explored whether transforming growth factor (TGF)-β signaling, an important oncogenic event sarcoma, modulates...
Using the model of additive tectonic stress from celestial tide-generating force, we studied relationship between seismogenic structure and in M7.8 Turkey earthquake on 6 February 2023. We analyzed daily continuous variation characteristics OLR before after discussed correlation tidal stress, OLR, earthquake. The results showed that observed anomaly according to cycle “C” (1–15 February) presented a phase change time, which was synchronized with trough-to-peak additional main pressure...
Abstract Background Synovial sarcoma (SS) is a type of soft tissue (STS) undetermined origin, which characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2). Studies have shown that SS malignant tumor originating from cancer stem cells or pluripotent mesenchymal and may be related to fusion genes. In addition, some studies indicated induction epithelial–mesenchymal transition (EMT) via TGF-β1/Smad signaling pathway leads metastasis. Methods We analyzed...
E1A binding protein p300 (P300) is a member of the histone acetyltransferase family transcriptional co‑activators, which are associated with various types cancer. Numerous studies have evaluated diagnostic value P300, but their results not consistent. Therefore, clinical study and meta‑analysis were performed in present to investigate prognostic P300 expression human malignant neoplasms. Immunohistochemical (IHC) analysis was used assess 43 paraffin‑embedded primary synovial sarcoma (SS)...
Objective: To investigate the significance of intestinal fatty acid binding protein (IFABP) in evaluation barrier dysfunction mice at early stage severe burn injury. Methods: Thirty-six 8-week-old C57BL/6 male were collected and divided into normal control group (n=6) scald (n=30) according to random number table. Back each mouse was placed hot water 90 ℃ for 10 s, causing full-thickness (hereinafter refer as burn) 30% total body surface area, while not inflicted with burns. Six taken, 6 1,...
Objective: To investigate the effects of sodium butyrate on intestinal barrier severe scald mice and related mechanism. Methods: Eighteen C57BL/6 female mice, aged eight to twelve weeks, were divided into sham group, pure scald+ group according random number table, with 6 in each group. Back mouse immersed 90 ℃ water for 9 s, causing full-thickness 30% total body surface area, while back 37 injury. All 3 groups intraperitoneally injected 1 mL sterile lactated Ringer's solution immediately...
To observe the effects of artificial dermis combined with basic fibroblast growth factor (bFGF) on treatment cicatrix and deep skin wounds.The clinical data 72 patients wounds repaired dermis, hospitalized in our unit from October 2010 to April 2015, conforming study criteria, were retrospectively analyzed. The types after resection cicatrices, burn without exposure tendon or bone, small area a total number 102. Wounds divided into group (A, n=60) dermis+ bFGF (B, n=42) according whether not...
Relevant studies have shown that methane gas has a close relationship with seismic activity. The concentration of released within tectonic zone can reflect the intensity status activities, which is important for monitoring. In this study, January 2020 Xinjiang Jiashi earthquake was taken as research object, and mature Robust Satellite Technique (RST) algorithm used to characterize L3-level product data from hyperspectral sensor, Atmospheric Infrared Sounder (AIRS), installed on Earth...
Identifying seismic CH4 anomalies via remote sensing has been verified as a legitimate method. However, there are still some problems, such unknown reliability due to the complex characteristics of anomalies. In this study, multi-dimensional and multi-scale methane anomaly extraction process for was constructed with Robust Satellite Technique (RST) based on Atmospheric Infrared Sounder (AIRS) data then applied 2023 Türkiye–Syria earthquake. This study obtained two-dimensional...
To understand the epidemiological characteristics of human respiratory syncytial virus (HRSV) among cases presenting with influenza-like illness (ILI) in Shenzhen City from 2019 to 2023.
Objective: To study the molecular epidemiological characteristics and genotypes of hantavirus carried by rodents in Shenzhen. Methods: Rodents were captured, their lung samples collected grinded for RNA extraction. The positive classified real-time fluorescence PCR. Rat nucleic acid selected to amplify nucleotide sequences partial M fragments (G2 segment) S reverse transcription-nested polymerase chain reaction (RT-nested PCR). PCR products then sequenced homology phylogenetic tree analyses...
The ischemic and inflammatory intestinal diseases are characterized by hypoxia, inflammation epithelial barrier loss. Endoplasmic reticulum (ER) stress autophagy have been implicated in inflammation. However, it is still unclear whether ER contribute to TJ dysfunction. Here, we deomonstrate that Caco-2 monolayers exposed the was disrupted as indicated decreased TER increased paracellular permeability, which accompanied reduction reorganization of proteins ZO-1, occludin claudin-1, activation...