A5016770855- Cancer Cells and Metastasis
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
Central People's Hospital of Zhanjiang
2025
Yale University
2024
Beijing Chao-Yang Hospital
2022
Capital Medical University
2022
Minhang District Central Hospital
2022
Fudan University
2022
<title>Abstract</title> Background Synovial sarcoma (SS) is an aggressive malignant soft tissue of undetermined origin that harbored potential metastasis and recurrence, which lead to poor prognoses. Polo-like kinase1 (PLK1) essential members serine/threonine kinase, plays a key role in cell cycle progression other cellular processes Therefore, PLK1 could act as promising target for the therapeutic cure various cancers, including low incidence sarcoma. Methods We selected SS paraffin samples...
Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of reproductive-age women worldwide with no cure. While macrophages have been intrinsically linked to the pathophysiology endometriosis, targeting them therapeutically has extremely challenging due their high heterogeneity and because these disease-associated (DAMs) can be either pathogenic or protective. Here, we report identification characterized by TET3 overexpression in human endometriosis lesions....
Gastric cancer (GC) progression is related with gene regulations.This study explored underlying regulatory axis of circRNA PVT1 (circPVT1) in GC.GC cell lines were detected for circPVT1 expression the normal mucous epithelial GES-1 as control. After regulation circPVT1, miR-423-5p and SMAD3 through transfection, CCK8 evaluated viability, Transwell measured migratory invasive capability cells. Luciferase verified paired bindings between CircPVT1 or SMAD3. The functions...
Abstract Background Synovial sarcoma (SS) is a type of soft tissue (STS) undetermined origin, which characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2). Studies have shown that SS malignant tumor originating from cancer stem cells or pluripotent mesenchymal and may be related to fusion genes. In addition, some studies indicated induction epithelial–mesenchymal transition (EMT) via TGF-β1/Smad signaling pathway leads metastasis. Methods We analyzed...