A5100751635- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Advanced Fluorescence Microscopy Techniques
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Neuroblastoma Research and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cell Image Analysis Techniques
- COVID-19 Clinical Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Food Science and Nutritional Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
Zhejiang University
2023-2024
Beijing Forestry University
2024
Zhejiang University-University of Edinburgh Institute
2022-2023
Jilin Medical University
2023
Jilin University
2023
Beijing University of Technology
2021
Green Chemistry
2021
Soochow University
2021
Huazhong University of Science and Technology
2020
Tongji Hospital
2020
Abstract The BCL2 inhibitor venetoclax has recently emerged as an important component of acute myeloid leukemia (AML) therapy. Notably, use this agent revealed a previously unrecognized form pathogenesis characterized by monocytic disease progression. We demonstrate that arises from fundamentally different type stem cell (LSC), which we designate LSC (m-LSC), is developmentally and clinically distinct the more well-described primitive (p-LSC). m-LSC distinguished unique immunophenotype...
<b><i>Background:</i></b> The mortality rate of critically ill patients with coronavirus disease 2019 (COVID-19) was high. We aimed to assess the association between prolonged intermittent renal replacement therapy (PIRRT) and in COVID-19 undergoing invasive mechanical ventilation. <b><i>Methods:</i></b> This retrospective cohort study included all receiving ventilation February 12 March 2, 2020. All were followed until death or 28, survivors...
Abstract Background For the coronavirus disease 2019 (COVID-19), critically ill patients had a high mortality rate. We aimed to assess association between prolonged intermittent renal replacement therapy (PIRRT) and in with COVID-19 undergoing invasive mechanical ventilation. Methods In this retrospective cohort study, we included all ventilation from February 12 nd March 2 , 2020. All were followed until death or 28 th survivors for at least 30 days. Results 36 hospitalized ventilation,...
We achieved the low-damage spatial puncture of single cells at specific visual points with an accuracy <65 nm.
Abstract Summary Computational methods that track single cells and quantify fluorescent biosensors in time-lapse microscopy images have revolutionized our approach studying the molecular control of cellular decisions. One barrier limits adoption single-cell analysis biomedical research is lack efficient to robustly over cell division events. Here, we developed an application automatically tracks assigns mother–daughter relationships cells. By incorporating cycle information from a...
Forests are one of the most important sources negative oxygen ions (NAIs). NAIs have been recognized as beneficial for both physical and mental well–being, higher concentrations associated with improved health. However, environmental factors that predominantly influence NAI concentration their relationship remain uncertain. This study aims to investigate dominant impact on by observing various in two different environments (natural forest urban forest) Beijing region over a one–year period....
<p>Supplementary Fig. 1: Immunophenotyping and WES analysis of primary AML specimens. Supplementary 2: engrafted cells in PDX. 3: remission duration VEN/AZA relapsed patients. 4: CITE-seq data analysis. 5: Sorting strategies for determining m-LSC immunophenotype expression various LSC markers m-LSCs. 6: Molecular properties targeting m-LSCs vitro vivo. 7: M5 but not M4 patients showing significantly higher refractory rate to therapy.</p>
<p>Supplementary Fig. 1: Immunophenotyping and WES analysis of primary AML specimens. Supplementary 2: engrafted cells in PDX. 3: remission duration VEN/AZA relapsed patients. 4: CITE-seq data analysis. 5: Sorting strategies for determining m-LSC immunophenotype expression various LSC markers m-LSCs. 6: Molecular properties targeting m-LSCs vitro vivo. 7: M5 but not M4 patients showing significantly higher refractory rate to therapy.</p>