A5075830148- Marine Sponges and Natural Products
- Cancer, Hypoxia, and Metabolism
- Microbial Natural Products and Biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Seaweed-derived Bioactive Compounds
- ATP Synthase and ATPases Research
- Marine and coastal plant biology
- Synthetic Organic Chemistry Methods
- Algal biology and biofuel production
- Protein Degradation and Inhibitors
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Ubiquitin and proteasome pathways
- Phytochemistry and Biological Activities
- Echinoderm biology and ecology
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Cancer Treatment and Pharmacology
- Metabolomics and Mass Spectrometry Studies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Tea Polyphenols and Effects
- Pharmacological Effects of Natural Compounds
University of Mississippi
2013-2024
Shanghai University of Traditional Chinese Medicine
2018-2023
University College Cork
2023
Liberal Arts University
2022
Hunan University of Traditional Chinese Medicine
2015
University of Louisiana at Monroe
2008
Suez Canal University
2008
Oregon State University
1990-2005
The University of Texas Southwestern Medical Center
1998-2004
United States Department of Agriculture
2004
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majusculaWilliam H. Gerwick, Philip J. Proteau, Dale G. Nagle, Ernest Hamel, Andrei Blokhin, Doris L. SlateCite this: Org. Chem. 1994, 59, 6, 1243–1245Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March...
Originally purified as a major lipid component of strain the cyanobacterium <i>Lyngbya majuscula</i> isolated in Curaçao, curacin A is potent inhibitor cell growth and mitosis, binding rapidly tightly at colchicine site tubulin. Because its molecular structure differs so greatly from that other inhibitors, we prepared series analogs to determine important structural features molecule. These modifications include reduction and<i>E</i>-to-<i>Z</i> transitions olefinic bonds 14-carbon side...
Pure natural products isolated from marine sponges, algae, and cyanobacteria were examined for antioxidant activity using a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) solution-based chemical assay 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) cellular-based assay. The DCFH system detects only antioxidants that penetrate cellular membranes. Potent identified the results each compared. algal metabolites cymopol (1), avrainvilleol (3), fragilamide (4), invertebrate constituent...
Antifungal compounds exert their activity through a variety of mechanisms, some which are poorly understood. Novel approaches to characterize the mechanism action antifungal agents will be great use in drug development process. The aim present study was investigate changes gene expression profile Saccharomyces cerevisiae following exposure representatives four currently available classes used management systemic fungal infections. Microarray analysis indicated differential 0.8, 4.1, 3.0, and...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majusculaJimmy Orjala, Dale G. Nagle, Victor Hsu, and William H. GerwickCite this: J. Am. Chem. Soc. 1995, 117, 31, 8281–8282Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://doi.org/10.1021/ja00136a031RIGHTS & PERMISSIONSArticle Views585Altmetric-Citations131LEARN ABOUT...
An analogue of dolastatin 13 (2) has been isolated from a marine cyanobacterium, Symploca hydnoides, collected near Guam. This new cyclic depsipeptide contains l-methionine sulfoxide residue; however, the exists as both R- and S-forms, resulting in doubling several signals 1H 13C NMR spectra. Structure elucidation required extensive application 2-D techniques such COSY, HMQC, HMBC, ROESY. The trivial name symplostatin 2 (1) assigned to metabolite its isolation S. hydnoides further supports...
Abstract Tanshinone IIA (Tan IIA), the primary bioactive compound derived from traditional Chinese medicine (TCM) Salvia miltiorrhiza Bunge, has been reported to possess antitumor activity. However, its mechanisms are not fully understood. To resolve potential mechanism(s) of Tan IIA, gene expression profiles our database was analyzed by connectivity map (CMAP) and CMAP-based mechanistic predictions were confirmed/validated in further studies. Specifically, inhibited total protein kinase C...
The aberrant activation of STAT3 is associated with the etiology and progression in a variety malignant epithelial-derived tumors, including head neck squamous cell carcinoma (HNSCC) colorectal cancer (CRC). Due to lack an enzymatic catalytic site or ligand-binding pocket, there are no small-molecule inhibitors directly targeting that have been approved for clinical translation. Emerging proteolysis chimeric (PROTAC) technology–based approach represents potential strategy overcome...
A new bioassay has been developed combining the simplicity of direct bioautography with improved chromatographic resolution 2D-TLC. Mixtures structurally diverse antifungal agents were tested to establish validity and utility this method in discovery natural products activity against agriculturally important fungal pathogens.
The transcription factor hypoxia-inducible factor-1 (HIF-1) is a key regulator of tumor cell adaptation and survival under hypoxic conditions. Selective HIF-1 inhibitors represent an important new class potential molecular-targeted antitumor therapeutic agents. Extracts plants marine organisms were evaluated using T47D human breast cell-based reporter assay for inhibitors. Bioassay-guided fractionation the lipid extract Saururus cernuus resulted in isolation manassantin B (1) compound,...
The application of oncolytic peptides has become a powerful approach to induce complete and long-lasting remission in multiple types carcinomas, as affirmed by the appearance tumor-associated antigens adenosine triphosphate (ATP) large quantities, which jumpstarts cancer-immunity cycle. However, ATP breakdown product is significant contributor forming immunosuppressive tumor microenvironment, substantially weakens peptide-driven immunotherapy. In this study, lipid-coated micelle (CA@TLM)...
Lyngbyastatin 1 (1a), a new cytotoxic analogue of dolastatins 12 (2a) and 11 (4), was isolated as an inseparable mixture with its C-15 epimer (1b) from extracts Lyngbya majuscula/Schizothrix calcicola assemblage L. majuscula strain collected near Guam. Dolastatin also encountered (2b) in majuscula/S. assemblages. At least one the compounds each appeared to exist solution slowly interconverting conformers resulting broadened signals 1H NMR spectra. Structure elucidation therefore relied...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 147:21-29 (1997) - doi:10.3354/meps147021 Effects of repeated exposures marine cyanobacterial secondary metabolites on feeding by juvenile rabbitfish and parrotfish Thacker RW, Nagle DG, Paul VJ Secondary isolated from algae cyanobacteria can act as deterrents a variety herbivores, but past studies have...
A new indanone (1) has been isolated from the filamentous marine cyanobacterium Lyngbya majuscula, and its structure determined spectroscopically. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis. Compound 1 inhibits hypoxia-induced activation VEGF gene promoter in Hep3B human liver cells, vitro.
The degree of tumor hypoxia correlates with advanced disease stages and treatment resistance. transcription factor hypoxia-inducible factor-1 (HIF-1) promotes cell adaptation survival under hypoxic conditions. Therefore, specific HIF-1 inhibitors represent an important new class potential tumor-selective therapeutic agents. A T47D human breast cell-based reporter assay was used to examine extracts plants marine organisms for activation. Bioassay-guided fractionation the lipid extract red...
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that induces oxygen-regulated genes in response to reduced oxygen conditions (hypoxia). Expression of the HIF-1α subunit correlates positively with advanced disease stages and poor prognosis cancer patients. Green tea catechins are believed be responsible for chemopreventive activities green tea. We found (−)-epicatechin-3-gallate (ECG, 1), one major catechins, strongly activates HIF-1 T47D human breast carcinoma cells. Among...