A5103210690- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- interferon and immune responses
- Drilling and Well Engineering
- Antimicrobial Peptides and Activities
- Advanced biosensing and bioanalysis techniques
- Hydraulic Fracturing and Reservoir Analysis
- Cancer Immunotherapy and Biomarkers
- Enhanced Oil Recovery Techniques
- Peptidase Inhibition and Analysis
- Mass Spectrometry Techniques and Applications
- Tryptophan and brain disorders
- CAR-T cell therapy research
- Earthquake Detection and Analysis
- Supramolecular Chemistry and Complexes
- Advanced Drug Delivery Systems
- Industrial Gas Emission Control
- Mechanical stress and fatigue analysis
- Structural Response to Dynamic Loads
- Cancer Research and Treatments
- Surgical Sutures and Adhesives
- graph theory and CDMA systems
- Cancer, Stress, Anesthesia, and Immune Response
Rice University
2018-2024
Chevron (United States)
2023
Chevron (Netherlands)
2020
Trinity University
2015
Lawrence Livermore National Laboratory
1976
American Society for Horticultural Science
1974
This paper describes the molecular recognition of tripeptide Tyr-Leu-Ala by synthetic receptor cucurbit[8]uril (Q8) in aqueous buffer with nanomolar affinity and exceptional specificity. combination characteristics, which also applies to antibodies, is desirable for applications biochemistry biotechnology but has eluded supramolecular chemists decades. Building on prior knowledge that Q8 binds peptides N-terminal aromatic residues, a library screen 105 was designed test effects residues...
In vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded natural collagen-based extracellular matrix is produced remodeling artificial material into tissue. These properties make MDPs particularly well suited for applications in regeneration. this work, we test regenerative potential of MDP diabetic wound healing model. When applied to full-thickness dermal wounds...
Background Intratumoral delivery of immunotherapeutics represents a compelling solution to directly address local barriers tumor immunity. However, we have previously shown that off-target is substantial problem during intratumoral injections; this can lead diminished drug efficacy and systemic toxicities. We identified three variables influence delivery: injection technique, formulation microenvironment. The purpose study was characterize the impact modifications in each variable on...
Self-assembly of peptides is a powerful method preparing nanostructured materials. These frequently utilize charged groups as convenient switch for controlling self-assembly in which pH or ionic strength determines the assembly state. Multidomain have been previously designed with domains amino acids, create molecular frustration between electrostatic repulsion and combination supramolecular forces including hydrogen bonding hydrophobic packing. This eliminated by addition multivalent ions...
We evaluated a peptide-based immunotherapy termed SynerGel: an injectable, biomaterial-based platform for intratumoral drug delivery. A drug-mimicking peptide hydrogel named L-NIL-MDP was loaded with antitumor cyclic dinucleotide (CDN) agonist. The biomaterial combines inducible nitric oxide synthase (iNOS) inhibition controlled delivery of CDNs, demonstrating between 4- and 20-fold slower release than commercially available hydrogels. SynerGel allowed immune-mediated elimination established...
Abstract Objectives/Scope Microbiologically influenced corrosion (MIC) is a complex issue both difficult to diagnose and challenging treat. Driven by variety of microbial species combinations under different process conditions mechanisms, MIC can appear unexpectedly be over- or under-diagnosed when using insufficient testing screening methods. This study's objective was develop an improved threat aid the development new early-warning methods for prevention. Methods, Procedures, Process For...
Abstract Although the principle of systemic treatment to prevent progression oral premalignant lesions (OPL) has been demonstrated, there remains a lack consensus about an optimal approach that balances clinical efficacy with toxicity concerns. Recent advances in cancer therapy using approaches targeting tumor immune microenvironment (TIME) including immune-checkpoint inhibitors indicate these agents have significant clinically activity against different types cancers, cancer, and therefore...
In this work, we develop a drug-mimicking nanofibrous peptide hydrogel that shows long-term bioactivity comparable to small-molecule inhibitor of inducible nitric oxide synthase (iNOS). The iNOS inhibitor, N 6-(1-iminoethyl)-l-lysine (l-NIL), is positively charged amino acid whose structure could be readily integrated into the framework multidomain (MDP) through modification lysine side chains. This new l-NIL-MDP maintains self-assembling properties base peptide, forming β-sheet nanofibers,...
A magic rectangle of order $m\times n$ with precisely $r$ filled cells in each row and $s$ column, denoted $MR(m,n;r,s)$, is an arrangement the numbers from 0 to $mr-1$ array such that number occurs exactly once sum entries same column also same. In this paper we study existence $MR(m,n;r,2)$, $MR(m,km;ks,s)$, $MR(am,bm;bs,as)$. We prove there exists a square set $MSS(m, s; t)$ if only $m=s=t=1$ or $3\leq s\leq m$ either even $mt$ odd.
Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer is debilitating, contributes diminished quality of life, causes opioid tolerance. The stimulator interferon genes (STING) agonism has been investigated as an anti-cancer strategy. We have developed STINGel, extended-release formulation that prolongs availability STING agonists, which demonstrated enhanced anti-tumor effect in OSCC compared...
Abstract Objectives/Scope Production of hydrogen sulfide (H2S) in O&G wells is a major issue for the industry due to concerns about toxicity, corrosion risks, and H2S takeaway limits that can result well shut-in. One primary methods manage production use scavengers, with triazines being most common. The scope this work was evaluate non-triazine alternative chemistries head-to-head incumbent products under challenging high CO2 conditions. Methods, Procedures, Process In study,...
Abstract I should like to discuss how two very different organizations can get together for their common good. This is a problem which not entirely new. John Ruskin, the great 19th century essayist, infuriated Asa Gray, an equally botanist, when he said that botanists are blind and stupid in maintaining purpose of flower production seed. “No such thing,” retorted “the seed flower.”