A5101745520- Electrospun Nanofibers in Biomedical Applications
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Biochemical effects in animals
- Mesenchymal stem cell research
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Asthma and respiratory diseases
- Sirtuins and Resveratrol in Medicine
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Virus-based gene therapy research
- Immune Response and Inflammation
Second Affiliated Hospital of Xi'an Jiaotong University
2009-2020
Xi'an Jiaotong University
2014
Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer, frequently occurring in Southeast Asia and Southern China. Several microRNAs (miRNAs) have been shown to an inhibitive effect on NPC, while the of miR-15a NPC remains unclear. Thus, our study aimed investigate potential cell proliferation, apoptosis, possible functional mechanism. Human CNE1 cells were transfected with mimics, inhibitors, or control. Afterward, viability apoptosis assayed by using CCK-8, BrdU assay, flow...
Human umbilical cord blood-derived mesenchymal stem cells (hUC-MSCs) have been widely used in tissue engineering. The aim of this study is to evaluate the ability poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) scaffolds coated with polyhydroxyalkanoate binding protein fused arginyl-glycyl-aspartic acid (PhaP-RGD) promote proliferation and chondrogenic differentiation hUC-MSCs seeded on them. PhaP-RGD fusion was expressed by Escherichia coli. PHBHHx films were physiochemical...
Abstract Sirtuin7 (SIRT7) is known to regulate apoptosis and stress responses. So far, very little about the role of SIRT7 in cerebral ischemia/reperfusion injury. In this study, we aimed investigate potential regulating oxygen‐glucose deprivation reoxygenation (OGD/R)‐induced injury neurons. We found a significant increase expression neurons response OGD/R treatment. Knockdown aggravated OGD/R‐induced augmented levels total acetylated p53 protein. Moreover, knockdown markedly increased...
Emerging studies have demonstrated that long non‑coding RNAs (lncRNAs) play essential roles in tumorigenesis. However, the role and function of lncRNAs hypopharyngeal squamous cell carcinoma (HSCC) not been completely elucidated. The present study explored a novel lncRNA, RP11‑156L14.1, HSCC. RP11‑156L14.1 was revealed to be highly expressed HSCC tissues lines. Knockdown inhibited proliferation, migration, invasion cells. Furthermore, regulated epithelial‑mesenchymal transition (EMT) by...