A5100455028- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Effects of Radiation Exposure
- Vestibular and auditory disorders
- Cardiac Imaging and Diagnostics
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Tea Polyphenols and Effects
- Fetal and Pediatric Neurological Disorders
- Mesenchymal stem cell research
- Microbial Community Ecology and Physiology
- Dementia and Cognitive Impairment Research
- Mental Health Research Topics
- Advanced Clustering Algorithms Research
- Medicinal Plants and Bioactive Compounds
- Hematopoietic Stem Cell Transplantation
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Titanium Alloys Microstructure and Properties
- MicroRNA in disease regulation
- Parasite Biology and Host Interactions
- Protease and Inhibitor Mechanisms
- Vitamin C and Antioxidants Research
Sino-Danish Centre for Education and Research
2021-2024
University of Chinese Academy of Sciences
2018-2024
Chinese Academy of Sciences
2014-2024
Institute of Automation
2021-2024
Technical University of Denmark
2024
Inner Mongolia Medical University
2023
Zhengzhou University
2022
Loudi Central Hospital
2021
Jiangxi Science and Technology Normal University
2019
Shenzhen Institutes of Advanced Technology
2019
Owning to its clinical accessibility, T1-weighted MRI (Magnetic Resonance Imaging) has been extensively studied in the past decades for prediction of Alzheimer's disease (AD) and mild cognitive impairment (MCI). The volumes gray matter (GM), white (WM) cerebrospinal fluid (CSF) are most commonly used measurements, resulting many successful applications. It widely observed that disease-induced structural changes may not occur at isolated spots, but several inter-related regions. Therefore,...
Cerebellar involvement in both motor and non-motor functions manifests specific regions of the human cerebellum, revealing functional heterogeneity within it.One compelling theory places cerebellar hierarchy along sensorimotor-association (SA) axis.Despite extensive neuroimaging studies, evidence for SA axis from different modalities scales was lacking.Thus, we establish a significant link between spatio-molecular profiles.Utilizing gene set variation analysis, find intermediate biological...
The purpose of this study was to investigate the radioprotective effects tea polyphenols (TPs) in various combinations against radiation‐induced damage mice. Mice were divided into different groups: non‐irradiated control, irradiated amifostine (43.6 mg/kg, i.v. 30 min before irradiation; positive control) and doses. effect on haematopoietic system, serum cytokines endogenous antioxidant enzymes studied. TP50, containing approximately 50% (‐)‐epigallochatechin‐3‐gallate addition other...
Tumor‐associated proteases (TAPs), such as legumain, are actively involved in cancer progression; they have been used biomarkers for diagnosis, prognosis, and drug targeting. As a result, in‐vivo detection trafficking of TAPs attracted great deal attention. TAP‐specific probes imaging, however, remain rare. A TAP‐responsive hybrid nanoprobe system based on quantum dots (QD) the fluorescence resonance energy transfer (FRET) effect is presented legumain (asparaginyl endopeptidase), which...
Abstract Comprising numerous subnuclei, the thalamus intricately interconnects cortex and subcortex, orchestrating various facets of brain functions. Extracting personalized parcellation patterns for these subnuclei is crucial, as different thalamic nuclei play varying roles in cognition serve therapeutic targets neuromodulation. However, accurately delineating boundary at individual level challenging due to intersubject variability. In this study, we proposed a prior‐guided (PG‐par) method...
This study investigated the anti-aging effects of Angelica sinensis polysaccharide (ASP) on mouse hematopoietic stem cells (HSCs) and related mechanisms.Seventy-two C57BL/6J mice were randomly divided into following three groups (n = 24 per group): control group; aging group, in which irradiated with X-ray uniformly to establish model HSCs; ASP given 200 mg/kg during irradiation. HSCs collected by immunomagnetic beads, transmission electron microscopy was used examine morphological changes...
The present study aimed to reveal the eukaryotic diets of two economically important marine sediment-inhabiting worms, Sipunculus nudus (peanut worm) and Urechis unicinctus (spoon worm), using clone libraries phylogenetic analyses 18S rRNA genes. Fungal rDNA was also targeted analyzed mycobiomes. Overall, we detected a wide range phylotypes associated with larvae S. in gut contents both worms. These included ciliates, diatoms, dinoflagellates, eustigmatophytes, placidids, oomycetes, fungi,...
Abstract The functional diversity of the human cerebellum is largely believed to be derived more from its extensive connections rather than being limited mostly invariant architecture. However, whether and how determination cerebellar in intrinsic organization interact with microscale gene expression still unknown. Here we decode genetic profiles by investigating substrates simultaneously linking heterogeneity drivers, i.e., connections. We not only identified 443 network-specific genes but...
Abstract Deep learning frameworks utilizing convolutional neural networks (CNNs) have frequently been used for brain age prediction and achieved outstanding performance. Nevertheless, deep remains a black box as it is hard to interpret which parts contribute significantly the predictions. To tackle this challenge, we first trained lightweight, fully CNN model estimation on large sample data set ( N = 3054, range [8,80 years]) tested an independent 555, mean absolute error (MAE) 4.45 years, r...
Individuals vary in behavior and cognition within a diseased or even "normal" population. Subtyping is critical for characterizing understanding individual variations behavior. Neuroimaging-based subtyping has emerged recently shown great potential clustering individuals with distinct neural patterns across sub-clusters. However, due to the high dimensional nature of neuroimaging data relatively limited sample size, commonly used methods most existing studies such as k-mean may undermine...
Abstract As a gateway for projections entering and exiting the cerebral cortex, human thalamus processes information from sensory to cognition relevant various neuropsychiatric disorders. It is composed of dozens nuclei, which have been difficult identify with clinical MR sequences. However, delineating thalamic nuclei accurately at an individual level essential precise neuromodulation treatment. Here, we not only identified fine-grained using local diffusion properties in vivo but also...
To study the effect of Angelica sinensis polysaccharide (ASP) on expression Sirt1/p53/p21 in radiation-induced aging hematopoietic stem cells (HSCs) mice, and to explore possible mechanism ASP regulating HSCs. Methods: C57BL/6J mice were randomly divided into control group, model group group. The was irradiated with X-ray 3.0Gy/8F establish HSCs mice. given intragastric administration during irradiation; equal volume normal saline. sorted by immunomagnetic beads, cell cycle detected flow...