A5062994019- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Airway Management and Intubation Techniques
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Genetic and Kidney Cyst Diseases
- Metabolism and Genetic Disorders
- Chronic Lymphocytic Leukemia Research
- Genetic diversity and population structure
- Computational Drug Discovery Methods
- Health and Wellbeing Research
- Cancer-related gene regulation
- Thyroid and Parathyroid Surgery
- Heme Oxygenase-1 and Carbon Monoxide
- Tissue Engineering and Regenerative Medicine
- Chromosomal and Genetic Variations
- RNA regulation and disease
- Liver physiology and pathology
- Colorectal Cancer Treatments and Studies
- Healthcare Systems and Public Health
- Gout, Hyperuricemia, Uric Acid
Gannan Medical University
2024-2025
First Hospital of Jilin University
2022-2023
Jilin University
2022-2023
Fudan University
2021-2023
Zhongshan Hospital
2021-2023
Sichuan University
2019-2020
tRNA-derived small RNAs (tsRNAs) are a class of novel RNAs, ubiquitously present in prokaryotes and eukaryotes. It has been reported that tsRNAs exhibit spatiotemporal expression patterns can function as regulatory molecules many biological processes. Current tsRNA databases only cover limited organisms ignore functional characteristics. Thus, integrating more relevant information is helpful for further exploration. Here, we database, named tsRBase, which integrates the pattern multiple...
Colorectal cancer (CRC), ranking third in prevalence and second mortality worldwide, is mainly derived from colorectal adenoma (CRA). CRA a common benign disease the intestine with rapidly increasing incidence malignant potential. Therefore, this study aimed to recognize significant biomarkers original pathogenesis CRA.Transcriptome data of GSE8671, GSE37364, GSE15960 were downloaded Gene Expression Omnibus (GEO) datasets, differentially expressed genes (DEGs) screened. Functional pathways...
Abstract The maternal inheritance of mitochondria is a widely accepted paradigm, and mechanisms that prevent paternal transmission to offspring during spermatogenesis postfertilization have been described. Although certain species do retain mitochondria, the factors affecting in these cases are unclear. More importantly, evolutionary benefit retaining their ultimate fate unknown. Here we show transplanted exogenous D. yakuba can be transmitted when dysfunctional melanogaster. Furthermore,...
Prostate cancer remains the second leading cause of male death and there is an unmet need for biomarkers to identify patients with such aggressive disease. Piwi-inteacting RNAs (piRNAs) has been classified as transcriptional post-transcriptional regulators gene expression in somatic cells. In this study, we discovered three piRNAs novel independent prognostic markers their association prostate biochemical recurrence (BCR) was confirmed validation dataset. To obtain a better understanding...
The causal association between education and cervical spondylosis may be mediated partly through risk factors of cardiovascular disease. identification the protective effect evaluation will help to optimize disease prevention at both clinical public health levels. In this study, we applied several different Mendelian randomization (MR) methods identify which underlie clustering with disease, degree these mediate an education. Univariable MR analyses provided evidence supporting a genetically...
Colorectal cancer (CRC) is a severe risk to public health, and there growing evidence that alternative splicing (AS) plays crucial role in cancer. However, the AS biomarkers CRC are seldom reported. In this study, we perform transcriptome analysis of colorectal samples for cancer-specific transcriptomic alterations. We identify 1577 splice events 885 genes, enriched CRC-associated pathways functions. parallel, find 10 factors (SFs) with variation or significant differential expression. Based...
Sepsis is regarded as a life-threatening organ dysfunction syndrome that responds to infection. Pyroptosis, unique form of programmed cell death, characterized by inflammatory cytokine secretion. Recently, an increasing number studies have investigated the relationship between sepsis and pyroptosis. Appropriate pyroptosis can help control infection during sepsis, but immoderate one may cause immune disorders. The present study aimed identify pyroptosis-related gene biomarkers their with...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by erosive arthritis, and current treatments for RA fall short of the outcomes expected clinicians patients.This study aimed to identify novel therapeutic prognostic targets in at genomic level screen desirable compounds with potential inhibitory effects on GZMB.We performed differential gene analysis GSE55235 GSE55457 from Gene Expression Omnibus (GEO) then obtained intersection two differentially expressed genes (DEGs) lists...
Recurrent laryngeal nerve injury is one of the most serious complications thyroid surgery. The use a recurrent monitor during surgery best way to protect from injury. For high-risk, complex surgery, intraoperative laryng-eal monitoring and visual identification can significantly reduce rate injury, signific-antly reducing risk non-recurrent Therefore, circuit nurses must master monitors precautions ensure normal operation real-time monitoring. Due fine anatomy neck, close relationship with...
Abstract Wnt/β-catenin signaling and its dysregulation play critical roles in the fate determination of stem cells pathology various diseases. However, application translated Wnt ligand regenerative medicine is hampered by hydrophobicity cross-reactivity with Frizzled (FZD) receptors. Here, we generate an engineered water-soluble, FZD subtype-specific agonist, RRP-pbFn, for high-efficiency activation. In absence direct binding to LRP5/6, RRP-pbFn stimulates more potently than surrogate Wnt....